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Adjuvant chemotherapy for locally advanced rectal cancer in elderly patients after neoadjuvant chemoradiotherapy and surgery Toxicity and survival outcomes

文献类型：期刊论文

作者Sun, Quanquan1,2; Liu, Tongxin1,2; Liu, Peng1,2; Lu, Ke1,2; Zhang, Na1,2; Liu, Luying1,2; Zhu, Yuan1,2
刊名MEDICINE
出版日期2020
卷号99
关键词adjuvant chemotherapy colorectal neoplasms geriatrics
ISSN号0025-7974
DOI10.1097/MD.0000000000018835
通讯作者Zhu, Yuan(zhuyuan63@hotmail.com)
英文摘要The treatment strategy for elderly patients with locally advanced rectal cancer (LARC) remains controversial. The aim of this study was to identify the significance of adjuvant chemotherapy (AC) for elderly patients with LARC after neoadjuvant chemoradiotherapy (nCRT) and surgical resection. Between February 2002 and December 2012, a total of 43 patients aged >= 70 years with LARC following nCRT and surgery were retrospectively reviewed. The median follow-up time was 51 months (range 15-161 months). All patients completed the programmed chemoradiotherapy, of which 20 patients (46.5%) received 5-fluorouracil-based AC, and other 23 patients (53.5%) received no adjuvant chemotherapy. The 5-year overall survival and disease-free survival rates for AC group and non-adjuvant chemotherapy (NAC) group were 74.7% vs 63.4% (P = .562) and 73.4% vs 66.3% (P = .445), respectively. More patients in AC group suffered from severe leucopenia than that in NAC group (60% vs 17.4%, P = .004). For elderly patients with LARC following nCRT and surgery, AC may not benefit for survival, but increase treatment related leucopenia.
WOS关键词III COLON-CANCER ; QUALITY-OF-LIFE ; PREOPERATIVE RADIOTHERAPY ; COLORECTAL-CANCER ; POOLED ANALYSIS
资助项目National Natural Science Foundation of China[81502646] ; National Natural Science Foundation of China[81502647] ; Zhejiang Provincial Natural Science Foundation of China[LY14H160009] ; Zhejiang Medical and Health Science and Technology Project[2016KYB042] ; Zhejiang Medical and Health Science and Technology Project[2018KY298]
WOS研究方向General & Internal Medicine
语种英语
WOS记录号WOS:000524580300038
出版者LIPPINCOTT WILLIAMS & WILKINS
资助机构National Natural Science Foundation of China ; Zhejiang Provincial Natural Science Foundation of China ; Zhejiang Medical and Health Science and Technology Project
源URL[http://ir.hfcas.ac.cn:8080/handle/334002/103727]  
专题中国科学院合肥物质科学研究院
通讯作者Zhu, Yuan
作者单位1.Univ Chinese Acad Sci, Dept Radiat Oncol, Canc Hosp, Hangzhou, Zhejiang, Peoples R China
2.Zhejiang Canc Hosp, Zhejiang Key Lab Radiat Oncol, Hangzhou, Zhejiang, Peoples R China
推荐引用方式
GB/T 7714		 Sun, Quanquan,Liu, Tongxin,Liu, Peng,et al. Adjuvant chemotherapy for locally advanced rectal cancer in elderly patients after neoadjuvant chemoradiotherapy and surgery Toxicity and survival outcomes[J]. MEDICINE,2020,99.
APA Sun, Quanquan.,Liu, Tongxin.,Liu, Peng.,Lu, Ke.,Zhang, Na.,...&Zhu, Yuan.(2020).Adjuvant chemotherapy for locally advanced rectal cancer in elderly patients after neoadjuvant chemoradiotherapy and surgery Toxicity and survival outcomes.MEDICINE,99.
MLA Sun, Quanquan,et al."Adjuvant chemotherapy for locally advanced rectal cancer in elderly patients after neoadjuvant chemoradiotherapy and surgery Toxicity and survival outcomes".MEDICINE 99(2020).

入库方式： OAI收割

来源：合肥物质科学研究院

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