The effectiveness of probiotics in prevention and treatment of cancer therapy-induced oral mucositis: A systematic review and meta-analysis
文献类型：期刊论文
| 作者 | Shu, Zekai2; Li, Peijing3,4; Yu, Bingqi1; Huang, Shuang3,4; Chen, Yuanyuan3,4 |
| 刊名 | ORAL ONCOLOGY
 |
| 出版日期 | 2020-03-01 |
| 卷号 | 102 |
| 关键词 | Probiotics Radiotherapy Chemotherapy Chemo-radiotherapy Oral mucositis Stomatitis Head and neck cancer |
| ISSN号 | 1368-8375 |
| DOI | 10.1016/j.oraloncology.2019.104559 |
| 通讯作者 | Chen, Yuanyuan(chenyy@zjcc.org.cn) |
| 英文摘要 | Oral mucositis (OM) is a common and troublesome adverse side effect of many cancer therapy modalities (chemotherapy, radiotherapy, and chemo-radiotherapy), which can cause pain, ulceration, dysphagia, malnutrition, even treatment interruption. Probiotics may be effective in preventing and treating of cancer therapy-induced OM. We performed a systematic review and meta-analysis of the effectiveness of probiotics in prevention and treatment of cancer therapy-induced OM. Four databases and one trial registry were searched as of the 12th of May 2019 to identify all eligible randomized controlled trials (RCT). Five studies involving 435 patients were included in this study. Methodological quality and outcomes were evaluated in every study included. Pooled results showed a moderate heterogeneity (P = 0.15, I-2 = 44%). The pooled RRs indicated that the use of probiotics decreased the risk of OM for grade >= 3 (RR = 0.66, 95%CI = 0.54-0.81, P < 0.0001) as well as all grades (RR = 0.83, 95% CI = 0.72-0.97, P = 0.02). There was no significant difference between probiotics and placebo for cancer therapy completion rate (RR = 1.14, 95%CI = 0.65-2.00, P = 0.64). The subgroup analysis indicated that the use of probiotics was not statistically significant for patients receiving chemo-radiotherapy (RR = 0.52, 95% CI = 0.26-1.04, P = 0.07). In conclusion, probiotics may reduce the incidence and mitigate the severity of cancer therapy-induced OM. Further trials with a randomized, double-blind and multicentric study design are needed to confirm this effect. The PROSPERO registration number of this systematic review and meta-analysis is CRD42019130414. |
| WOS关键词 | LACTOBACILLUS-BREVIS CD2 ; DOUBLE-BLIND ; NECK-CANCER ; RADIATION ; HEAD ; SAFETY ; RISK ; CHEMOTHERAPY ; MICROBIOME ; MANAGEMENT |
| WOS研究方向 | Oncology ; Dentistry, Oral Surgery & Medicine |
| 语种 | 英语 |
| WOS记录号 | WOS:000518642200027 |
| 出版者 | ELSEVIER |
| 源URL | [http://ir.hfcas.ac.cn:8080/handle/334002/103769]  |
| 专题 | 中国科学院合肥物质科学研究院 |
| 通讯作者 | Chen, Yuanyuan |
| 作者单位 | 1.Zhejiang Hosp, Hangzhou, Zhejiang, Peoples R China 2.Zhejiang Chinese Med Univ, Clin Med Coll 2, Hangzhou, Zhejiang, Peoples R China 3.Chinese Acad Sci, Inst Canc Res & Basic Med Sci, Beijing, Peoples R China 4.Univ Chinese Acad Sci, Zhejiang Canc Hosp, Canc Hosp, Beijing, Peoples R China |
| 推荐引用方式 GB/T 7714 | Shu, Zekai,Li, Peijing,Yu, Bingqi,et al. The effectiveness of probiotics in prevention and treatment of cancer therapy-induced oral mucositis: A systematic review and meta-analysis[J]. ORAL ONCOLOGY,2020,102. |
| APA | Shu, Zekai,Li, Peijing,Yu, Bingqi,Huang, Shuang,&Chen, Yuanyuan.(2020).The effectiveness of probiotics in prevention and treatment of cancer therapy-induced oral mucositis: A systematic review and meta-analysis.ORAL ONCOLOGY,102. |
| MLA | Shu, Zekai,et al."The effectiveness of probiotics in prevention and treatment of cancer therapy-induced oral mucositis: A systematic review and meta-analysis".ORAL ONCOLOGY 102(2020). |
入库方式： OAI收割
来源：合肥物质科学研究院
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。