Single-layer boron-doped graphene quantum dots for contrast-enhanced in vivo T-1-weighted MRI
文献类型：期刊论文
| 作者 | Wang, Hui1,2; Revia, Richard2; Mu, Qingxin2; Lin, Guanyou2; Yen, Charles2; Zhang, Miqin2 |
| 刊名 | NANOSCALE HORIZONS
 |
| 出版日期 | 2020-03-01 |
| 卷号 | 5 |
| ISSN号 | 2055-6756 |
| DOI | 10.1039/c9nh00608g |
| 通讯作者 | Zhang, Miqin(mzhang@uw.edu) |
| 英文摘要 | Gadolinium (Gd)-based chelates are used as clinical T-1 contrast agents for magnetic resonance imaging (MRI) due to their demonstrated high sensitivity and positive contrast enhancement capability. However, there has been an increasing safety concern about their use in medicine because of the toxicity of the metal ions released from these contrast agents when used in vivo. Although significant effort has been made in developing metal-free MRI contrast agents, none have matched the magnetic properties achieved by the gold standard clinical contrast agent, Gd diethylene penta-acetic acid (Gd-DTPA). Here, we report the development of a single-layer, boron-doped graphene quantum dot (termed SL-BGQD) that demonstrates better T-1 contrast enhancement than Gd-DTPA. The SL-BGQD is shown to provide significantly higher positive contrast enhancement than the Gd-DTPA contrast agent in imaging vital organs, including kidneys, liver, and spleen, and especially, vasculatures. Further, our results show that the SL-BQGD is able to bypass the blood-brain barrier and allows sustained imaging for at least one hour with a single injection. Hematological and histopathological analyses show that the SL-BGQD demonstrates a non-toxic profile in wild-type mice and may, therefore, serve as an improved, safer alternative to currently available clinical MRI contrast agents. |
| WOS关键词 | IRON-OXIDE NANOPARTICLES ; CARBON ; EXFOLIATION ; FABRICATION ; DIAGNOSIS ; TOXICITY ; CANCER ; AGENTS ; ACID |
| 资助项目 | NIH[R01CA161953] ; NIH[R01EB026890] ; NIH[F31CA232546] ; Kyocera Professorship Endowment ; Biomedical Research Shared Instrumentation Grant[S10RR029021] ; NSF[NNCI-1542101] ; National Cancer Institute of the National Institutes of Health[F31CA232546] |
| WOS研究方向 | Chemistry ; Science & Technology - Other Topics ; Materials Science |
| 语种 | 英语 |
| WOS记录号 | WOS:000518686600013 |
| 出版者 | ROYAL SOC CHEMISTRY |
| 资助机构 | NIH ; Kyocera Professorship Endowment ; Biomedical Research Shared Instrumentation Grant ; NSF ; National Cancer Institute of the National Institutes of Health |
| 源URL | [http://ir.hfcas.ac.cn:8080/handle/334002/103783]  |
| 专题 | 中国科学院合肥物质科学研究院 |
| 通讯作者 | Zhang, Miqin |
| 作者单位 | 1.Chinese Acad Sci, Hefei Inst Phys Sci, High Field Magnet Lab, Anhui Key Lab Condensed Matter Phys Extreme Condi, Hefei 230031, Anhui, Peoples R China 2.Univ Washington, Dept Mat Sci & Engn, Seattle, WA 98195 USA |
| 推荐引用方式 GB/T 7714 | Wang, Hui,Revia, Richard,Mu, Qingxin,et al. Single-layer boron-doped graphene quantum dots for contrast-enhanced in vivo T-1-weighted MRI[J]. NANOSCALE HORIZONS,2020,5. |
| APA | Wang, Hui,Revia, Richard,Mu, Qingxin,Lin, Guanyou,Yen, Charles,&Zhang, Miqin.(2020).Single-layer boron-doped graphene quantum dots for contrast-enhanced in vivo T-1-weighted MRI.NANOSCALE HORIZONS,5. |
| MLA | Wang, Hui,et al."Single-layer boron-doped graphene quantum dots for contrast-enhanced in vivo T-1-weighted MRI".NANOSCALE HORIZONS 5(2020). |
入库方式： OAI收割
来源：合肥物质科学研究院
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