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A NOVEL PROGNOSTIC INDEX IN PATIENTS WITH RESECTABLE ESOPHAGEAL SQUAMOUS CELL CARCINOMA: FIBRINOGEN/PREALBUMIN RATIO

文献类型：期刊论文

作者Feng, Ji-Feng1,2; Wang, Liang1; Jiang, You-Hua1,2; Yang, Xun1,2
刊名REVISTA DE INVESTIGACION CLINICA-CLINICAL AND TRANSLATIONAL INVESTIGATION
出版日期2020
卷号72
关键词Esophageal squamous cell carcinoma Fibrinogen Albumin Prealbumin Cancer-specific survival Overall survival Prognosis
ISSN号0034-8376
DOI10.24875/RIC.19003184
通讯作者Feng, Ji-Feng(Fengjf@zjcc.org.cn)
英文摘要Background: Fibrinogen (Fib) to albumin (ALB) fibrinogen-to-albumin ratio as a prognostic index for esophageal cancer has been confirmed. A novel prognostic index was initially proposed with fibrinogen to prealbumin ratio (FPR) in patients with resectable esophageal squamous cell carcinoma (ESCC). Objective: The objective of the study was to study the prognostic role of the novel prognostic index (FPR) in patients with resectable ESCC without any neoadjuvant treatment. Methods: In this retrospective study, a total of 372 resectable ESCC patients without any neoadjuvant treatment were included. The best cutoff values were selected by the receiver operating characteristic curves. Two Cox regression analyses with forward stepwise (one for categorical variables and the other for continuous variables) were used to evaluate the overall survival (OS) and cancer-specific survival (CSS). Results: The best cutoff point was 0.014 for FPR. Patients with lower levels of FPR (<= 0.014) had better CSS (50.7% vs. 18.0%, p < 0.001) and OS (48.0% vs. 17.6%, p < 0.001) than patients with higher levels of FPR (> 0.014). Multivariate Cox analyses (categorical and continuous) demonstrated that FPR was an independent prognostic factor in CSS (categorical: hazard ratio [HR]: 2.014, 95% confidence interval [CI]: 1.504-2.697, p < 0.001; continuous per 0.01: HR: 1.438, 95% CI: 1.154-1.793, p = 0.001) and OS (categorical: HR: 1.964, 95% CI: 1.475-2.617, p < 0.001; continuous per 0.01: HR: 1.429, 95% CI: 1.146-1.781, p = 0.002). Conclusions: Our study indicated that FPR served as an independent prognostic factor in patients with resectable ESCC.
WOS关键词NEOADJUVANT CHEMORADIOTHERAPY ; PLASMA-FIBRINOGEN ; CANCER ; SURGERY ; CHEMOTHERAPY ; METASTASIS ; PREDICTORS ; MORTALITY
资助项目Medical Health Science and Technology Project of the Zhejiang Provincial Health Commission[2018KY290] ; Medical Health Science and Technology Project of the Zhejiang Provincial Health Commission[2019RC129] ; Medical Health Science and Technology Project of the Zhejiang Provincial Health Commission[2019RC128]
WOS研究方向General & Internal Medicine
语种英语
WOS记录号WOS:000518828100007
出版者INST NACIONAL NUTRICION
资助机构Medical Health Science and Technology Project of the Zhejiang Provincial Health Commission
源URL[http://ir.hfcas.ac.cn:8080/handle/334002/103795]  
专题中国科学院合肥物质科学研究院
通讯作者Feng, Ji-Feng
作者单位1.Univ Chinese Acad Sci, Zhejiang Canc Hosp, Inst Canc Res & Basic Med Sci, Canc Hosp,Dept Thorac Oncol Surg, Beijing, Peoples R China
2.Zhejiang Canc Hosp, Zhejiang Canc Res Inst, Key Lab Diag & Treatment Technol Thorac Oncol, Hangzhou, Peoples R China
推荐引用方式
GB/T 7714		 Feng, Ji-Feng,Wang, Liang,Jiang, You-Hua,et al. A NOVEL PROGNOSTIC INDEX IN PATIENTS WITH RESECTABLE ESOPHAGEAL SQUAMOUS CELL CARCINOMA: FIBRINOGEN/PREALBUMIN RATIO[J]. REVISTA DE INVESTIGACION CLINICA-CLINICAL AND TRANSLATIONAL INVESTIGATION,2020,72.
APA Feng, Ji-Feng,Wang, Liang,Jiang, You-Hua,&Yang, Xun.(2020).A NOVEL PROGNOSTIC INDEX IN PATIENTS WITH RESECTABLE ESOPHAGEAL SQUAMOUS CELL CARCINOMA: FIBRINOGEN/PREALBUMIN RATIO.REVISTA DE INVESTIGACION CLINICA-CLINICAL AND TRANSLATIONAL INVESTIGATION,72.
MLA Feng, Ji-Feng,et al."A NOVEL PROGNOSTIC INDEX IN PATIENTS WITH RESECTABLE ESOPHAGEAL SQUAMOUS CELL CARCINOMA: FIBRINOGEN/PREALBUMIN RATIO".REVISTA DE INVESTIGACION CLINICA-CLINICAL AND TRANSLATIONAL INVESTIGATION 72(2020).

入库方式： OAI收割

来源：合肥物质科学研究院

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