中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
首页 机构 成果 学者
  
  1. CAS IR Grid
  2. 合肥物质科学研究院
  3. 中国科学院合肥物质科学研究院
Enhanced in Vivo Blood-Brain Barrier Penetration by Circular Tau-Transferrin Receptor Bifunctional Aptamer for Tauopathy Therapy

文献类型：期刊论文

作者Li, Xiaowei4,5,7; Yang, Yu4,5,7; Zhao, Hengzhi4,5,7; Zhu, Tian2; Yang, Zhihui2; Xu, Haiyan2; Fu, Yueqiang2; Lin, Fan2; Pan, Xiaoshu4,5,7; Li, Long4,5,7
刊名JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
出版日期2020-02-26
卷号142
ISSN号0002-7863
DOI10.1021/jacs.9b11490
通讯作者Wang, Kevin K.(kwang@ufl.edu) ; Tan, Weihong(tan@hnu.edu.cn)
英文摘要The lack of blood-brain barrier (BBB) penetrating ability has hindered the delivery of many therapeutic agents for tauopathy treatment. In this study, we report the synthesis of a circular bifunctional aptamer to enhance the in vivo BBB penetration for better tauopathy therapy. The circular aptamer consists of one reported transferrin receptor (TfR) aptamer to facilitate TfR-aptamer recognition-induced transcytosis across BBB endothelial cells, and one Tau protein aptamer that we recently selected to inhibit Tau phosphorylation and other tauopathy-related pathological events in the brain. This novel circular Tau-TfR bifunctional aptamer displays significantly improved plasma stability and brain exposure, as well as the ability to disrupt tauopathy and improve traumatic brain injury (TBI)-induced cognitive/memory deficits in vivo, providing important proof-of-principle evidence that circular Tau-TfR aptamer can be further developed into diagnostic and therapeutic candidates for tauopathies.
WOS关键词PROTEIN ; AGGREGATION ; ANTIBODIES ; VITRO ; MODEL
资助项目DOD[AZ180105] ; DOD[21827811]
WOS研究方向Chemistry
语种英语
出版者AMER CHEMICAL SOC
WOS记录号WOS:000517360400024
资助机构DOD
源URL[http://ir.hfcas.ac.cn:8080/handle/334002/103907]  
专题中国科学院合肥物质科学研究院
通讯作者Wang, Kevin K.; Tan, Weihong
作者单位1.Chinese Acad Sci, Inst Canc & Basic Med IBMC, Hangzhou 310022, Zhejiang, Peoples R China
2.Univ Florida, McKnight Brain Inst, Dept Psychiat, Dept Emergency Med,Dept Neurosci, Gainesville, FL 32611 USA
3.Malcom Randall Vet Affairs Med Ctr, BRRC, Gainesville, FL 32608 USA
4.Univ Florida, UF Genet Inst, Hlth Canc Ctr, Ctr Res Bio Nano Interface,Dept Chem, Gainesville, FL 32611 USA
5.Univ Florida, UF Genet Inst, Hlth Canc Ctr, Ctr Res Bio Nano Interface,Dept Physiol & Funct G, Gainesville, FL 32611 USA
6.Hunan Univ, Aaptamer Engn Ctr Hunan Prov, Coll Biol,Coll Chem & Chem Engn, State Key Lab Chemo Biosensing & Chemometr,Mol Sc, Changsha 410082, Hunan, Peoples R China
7.Univ Florida, McKnight Brain Inst, Gainesville, FL 32611 USA
8.Liaocheng Univ, Sch Chem & Chem Engn, Liaocheng 252059, Shandong, Peoples R China
9.Univ Chinese Acad Sci, Canc Hosp, Hangzhou 310022, Zhejiang, Peoples R China
推荐引用方式
GB/T 7714		 Li, Xiaowei,Yang, Yu,Zhao, Hengzhi,et al. Enhanced in Vivo Blood-Brain Barrier Penetration by Circular Tau-Transferrin Receptor Bifunctional Aptamer for Tauopathy Therapy[J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY,2020,142.
APA Li, Xiaowei.,Yang, Yu.,Zhao, Hengzhi.,Zhu, Tian.,Yang, Zhihui.,...&Tan, Weihong.(2020).Enhanced in Vivo Blood-Brain Barrier Penetration by Circular Tau-Transferrin Receptor Bifunctional Aptamer for Tauopathy Therapy.JOURNAL OF THE AMERICAN CHEMICAL SOCIETY,142.
MLA Li, Xiaowei,et al."Enhanced in Vivo Blood-Brain Barrier Penetration by Circular Tau-Transferrin Receptor Bifunctional Aptamer for Tauopathy Therapy".JOURNAL OF THE AMERICAN CHEMICAL SOCIETY 142(2020).

入库方式： OAI收割

来源：合肥物质科学研究院

浏览0
下载0
收藏0
其他版本

除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。