Assessment of micafungin loading dosage regimens against Candida spp. in ICU patients by Monte Carlo simulations
文献类型：期刊论文
| 作者 | Lu, Xiaoqing2; Xu, Gaoqi3,4,5; Chen, Lu2 ; Fan, Jingjing6; Li, Mengxue2; Zhu, Liqin1,2
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| 刊名 | EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY
 |
| 出版日期 | 2020-02-11 |
| 关键词 | Micafungin Loading dose Candida spp ICU patients |
| ISSN号 | 0031-6970 |
| DOI | 10.1007/s00228-020-02840-0 |
| 通讯作者 | Zhu, Liqin(zlq0713@aliyun.com) |
| 英文摘要 | Objective To assess the efficacy of loading dose on micafungin by simulating different dosage regimens. Methods A published study of micafungin in ICU patients was employed to simulate nine different dosage regimens which were sorted out three groups in terms of three maintenance doses. Using pharmacokinetic parameters and pharmacodynamic data, 5000-subject Monte Carlo simulations were conducted to simulate concentration-time profiles of micafungin, calculate probabilities of target attainment (PTAs), and cumulative fractions of response (CFRs) in terms of AUC/MIC targets. PTAs were calculated using AUC/MIC cut-offs: 285 (Candida parapsilosis), 3000 (all Candida spp.), and 5000 (non-parapsilosis Candida spp.). PTA or CFR > 90% was considered optimal for a dosage regimen. Results The concentration-time profiles of micafungin-simulated dosage regimens were obtained. PTA values were over 90% while applying the loading dose in each group of regimens: for Candida albicans and Candida glabrata (AUC/MIC = 5000), all regimens with loading dose provided PTAs of >= 90% for MIC <= 0.008 mg/L. The PTAs (AUC/MIC = 3000) were over 90% for MIC <= 0.008 mg/L in any regimen. However, for MIC inferior to 0.016 mg/L, only loading dosage regimens provided PTAs exceeding 90%. For C. parapsilosis (AUC/MIC = 285), the maximum MIC of achieving a PTA >= 90% was 0.25 mg/L both in the regimens of B (150 mg maintenance dose) and C (200 mg maintenance dose) with loading dose. In addition, CFR of any regimen with loading dose was >= 90% against C. albicans and C. glabrata. None of the dosage regimens achieved an expected CFR against C. parapsilosis. Conclusions The dosage regimen of micafungin which had a loading dose of 1.5 times was more suitable for ICU patients infected by Candida spp. |
| WOS关键词 | INFECTIOUS-DISEASES SOCIETY ; CRITICALLY-ILL PATIENTS ; INVASIVE CANDIDIASIS ; PHARMACOKINETICS ; ECHINOCANDIN ; CASPOFUNGIN ; EFFICACY ; PHARMACODYNAMICS ; ANIDULAFUNGIN ; VORICONAZOLE |
| WOS研究方向 | Pharmacology & Pharmacy |
| 语种 | 英语 |
| WOS记录号 | WOS:000517463700001 |
| 出版者 | SPRINGER HEIDELBERG |
| 源URL | [http://ir.hfcas.ac.cn:8080/handle/334002/103967]  |
| 专题 | 中国科学院合肥物质科学研究院 |
| 通讯作者 | Zhu, Liqin |
| 作者单位 | 1.Tianjin First Cent Hosp, Dept Pharm, 24 Fukang Rd, Tianjin 300192, Peoples R China 2.Tianjin Med Univ, Pharmaceut Coll, Tianjin, Peoples R China 3.Chinese Acad Sci, ICBM, Hangzhou, Zhejiang, Peoples R China 4.Univ Chinese Acad Sci, Canc Hosp, Dept Pharm, Hangzhou, Zhejiang, Peoples R China 5.Zhejiang Canc Hosp, Dept Pharm, Hangzhou, Zhejiang, Peoples R China 6.Tianjin Univ Tradit Chinese Med, Grad Sch, Tianjin, Peoples R China |
| 推荐引用方式 GB/T 7714 | Lu, Xiaoqing,Xu, Gaoqi,Chen, Lu,et al. Assessment of micafungin loading dosage regimens against Candida spp. in ICU patients by Monte Carlo simulations[J]. EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY,2020. |
| APA | Lu, Xiaoqing,Xu, Gaoqi,Chen, Lu,Fan, Jingjing,Li, Mengxue,&Zhu, Liqin.(2020).Assessment of micafungin loading dosage regimens against Candida spp. in ICU patients by Monte Carlo simulations.EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY. |
| MLA | Lu, Xiaoqing,et al."Assessment of micafungin loading dosage regimens against Candida spp. in ICU patients by Monte Carlo simulations".EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY (2020). |
入库方式： OAI收割
来源：合肥物质科学研究院
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