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Magnetic-induced graphene quantum dots for imaging-guided photothermal therapy in the second near-infrared window

文献类型：期刊论文

作者Liu, Hongji1,4; Li, Changwei2; Qian, Yong1; Hu, Lin1; Fang, Jun1; Tong, Wei1; Nie, Rongrong3; Chen, Qianwang1,4; Wang, Hui1
刊名BIOMATERIALS
出版日期2020-02-01
卷号232
ISSN号0142-9612
关键词Magnetic field Graphene quantum dot NIR-II absorbance Photothermal conversion Cancer therapy
DOI10.1016/j.biomaterials.2019.119700
通讯作者Nie, Rongrong(nrr63@nju.edu.cn) ; Chen, Qianwang(cqw@ustc.edu.cn) ; Wang, Hui(hw39@hmfl.ac.cn)
英文摘要Graphene quantum dots (GQDs) are considered emerging nanomaterials for photothermal therapy (PTT) of cancer due to their good biocompatibility and rapid excretion. However, the optical absorbance of GQDs in shorter wavelengths (< 1000 nm) limits their overall therapeutic efficacies as photothermal agent in the second near infrared window (1000-1700 nm, NIR-II). Herein, we report a type of GQDs with strong absorption (1070 nrn) in NIR-II region that was synthesized via a one-step solvothermal treatment using phenol as single precursor by tuning the decomposition of hydrogen peroxide under a high magnetic field with an intensity of 9T. The obtained 9T-GQDs demonstrate uniform size distribution (3.6 nm), and tunable fluorescence (quantum yield, 16.67%) and high photothermal conversion efficacy (33.45%). In vitro and in vivo results indicate that 9T-GQDs could efficiently ablate tumor cells and inhibit the tumor growth under NIR-II irradiation. Moreover, the 9T-GQDs exhibited enhanced NIR imaging of tumor in living mice, suggesting the great probability of using 9T-GQDs for in vivo MR imaging-guided PTT in the NIR-II window.
WOS关键词NIR-I ; NANOPARTICLES ; SPECTROSCOPY ; CATALYSTS ; TOXICITY ; EMISSION ; NITROGEN ; CARRIER ; DESIGN ; VITRO
资助项目Chinese Academy of Sciences[1600000012] ; Collaborative Innovation Program of Hefei Science Center of CAS[2019HSC-CIP012] ; National Natural Science Foundation (NSFC)[21271163] ; Anhui Province Key Laboratory of Medical Physics and Technology[LMPT201701] ; Key Laboratory of Photovoltaic Materials and Energy Conservation of Chinese Academy of Sciences[PECL2019KF016]
WOS研究方向Engineering ; Materials Science
语种英语
出版者ELSEVIER SCI LTD
WOS记录号WOS:000514748200042
资助机构Chinese Academy of Sciences ; Collaborative Innovation Program of Hefei Science Center of CAS ; National Natural Science Foundation (NSFC) ; Anhui Province Key Laboratory of Medical Physics and Technology ; Key Laboratory of Photovoltaic Materials and Energy Conservation of Chinese Academy of Sciences
源URL[http://ir.hfcas.ac.cn:8080/handle/334002/103991]  
专题中国科学院合肥物质科学研究院
通讯作者Nie, Rongrong; Chen, Qianwang; Wang, Hui
作者单位1.Chinese Acad Sci, Hefei Inst Phys Sci, Anhui Key Lab Condensed Matter Phys Extreme Condi, High Magnet Field Lab, Hefei 230031, Anhui, Peoples R China
2.Shanghai Jiao Tong Univ, Shanghai Inst Traumatol & Orthopaed, Ruijin Hosp,Sch Med, Shanghai Key Lab Prevent & Treatment Bone & Joint, 197 Ruijin 2nd Rd, Shanghai 200025, Peoples R China
3.Nanjing Univ, Nanjing Stomatol Hosp, Med Sch, Nanjing 210008, JS, Peoples R China
4.Univ Sci & Technol China, Hefei Natl Lab Phys Sci Microscale, Dept Mat Sci & Engn, Hefei 230026, Anhui, Peoples R China
推荐引用方式
GB/T 7714		 Liu, Hongji,Li, Changwei,Qian, Yong,et al. Magnetic-induced graphene quantum dots for imaging-guided photothermal therapy in the second near-infrared window[J]. BIOMATERIALS,2020,232.
APA Liu, Hongji.,Li, Changwei.,Qian, Yong.,Hu, Lin.,Fang, Jun.,...&Wang, Hui.(2020).Magnetic-induced graphene quantum dots for imaging-guided photothermal therapy in the second near-infrared window.BIOMATERIALS,232.
MLA Liu, Hongji,et al."Magnetic-induced graphene quantum dots for imaging-guided photothermal therapy in the second near-infrared window".BIOMATERIALS 232(2020).

入库方式： OAI收割

来源：合肥物质科学研究院

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