A facile and efficient approach for hypertrophic scar therapyviaDNA-based transdermal drug delivery
文献类型：期刊论文
| 作者 | Jiang, Kai2; Chen, Yunsheng3; Zhao, Di2; Cheng, Jin2; Mo, Fangli2; Ji, Bin2; Gao, Chao2; Zhang, Chuan4; Song, Jie1,2,5 |
| 刊名 | NANOSCALE
 |
| 出版日期 | 2020-09-28 |
| 卷号 | 12 |
| ISSN号 | 2040-3364 |
| DOI | 10.1039/d0nr04751a |
| 通讯作者 | Song, Jie(J.S.sjie@sjtu.edu.cn) |
| 英文摘要 | The transdermal drug delivery approach has been considered a potential therapy for human hypertrophic scars (HSs) instead of current uncomfortable surgical excision, local injection and laser therapy. However, a facile and efficient drug delivery method is urgently needed to overcome the skin barrier of transdermal administration. Herein, we employed a DNA-Fe nanoparticle delivery systemviaFe ion driven self-assembly to satisfy the requirement of transdermal administration for HS therapy. Doxorubicin hydrochloride (DOX) as one of the widely used anticancer drugs was employed to treat the hyperplasia of abnormal skin fibrous tissue. Bothin vitroandin vivoexperiments of the DOX loaded DNA-Fe nanoparticles (DOX@DNA-Fe NPs) were performed to demonstrate the penetration ability, rapid drug release, and scar-inhibiting effects. This facile and efficient approach for HS therapyviaa DNA-based transdermal drug delivery system may provide more possibilities for the development of transdermal administration. |
| 资助项目 | National Natural Science Foundation of China[81822024] ; National Natural Science Foundation of China[11761141006] ; Natural Science Foundation of Shanghai, China[19520714100] ; Natural Science Foundation of Shanghai, China[19ZR1475800] ; National Key Research and Development Program of China[2017YFC1200904] ; Medical Engineering Cross Project of Shanghai Jiaotong University[YG2017ZD07] |
| WOS研究方向 | Chemistry ; Science & Technology - Other Topics ; Materials Science ; Physics |
| 语种 | 英语 |
| 出版者 | ROYAL SOC CHEMISTRY |
| WOS记录号 | WOS:000572677500013 |
| 资助机构 | National Natural Science Foundation of China ; Natural Science Foundation of Shanghai, China ; National Key Research and Development Program of China ; Medical Engineering Cross Project of Shanghai Jiaotong University |
| 源URL | [http://ir.hfcas.ac.cn:8080/handle/334002/104211]  |
| 专题 | 中国科学院合肥物质科学研究院 |
| 通讯作者 | Song, Jie |
| 作者单位 | 1.Chinese Acad Sci, Inst Canc & Basic Med ICBM, Hangzhou 310022, Peoples R China 2.Shanghai Jiao Tong Univ, Sch Elect Informat & Elect Engn, Inst Nano Biomed & Engn, Dept Instrument Sci & Engn, Shanghai 200240, Peoples R China 3.Shanghai Jiao Tong Univ, Shanghai Peoples Hosp 9, Dept Plast & Reconstruct Surg, Sch Med, 639 Zhizaoju Rd, Shanghai 200011, Peoples R China 4.Shanghai Jiao Tong Univ, Sch Chem & Chem Engn, State Key Lab Met Matrix Composites, Frontiers Sci Ctr Ransformat Mol, 800 Dongchuan Rd, Shanghai 200240, Peoples R China 5.Univ Chinese Acad Sci, Canc Hosp, Hangzhou 310022, Peoples R China |
| 推荐引用方式 GB/T 7714 | Jiang, Kai,Chen, Yunsheng,Zhao, Di,et al. A facile and efficient approach for hypertrophic scar therapyviaDNA-based transdermal drug delivery[J]. NANOSCALE,2020,12. |
| APA | Jiang, Kai.,Chen, Yunsheng.,Zhao, Di.,Cheng, Jin.,Mo, Fangli.,...&Song, Jie.(2020).A facile and efficient approach for hypertrophic scar therapyviaDNA-based transdermal drug delivery.NANOSCALE,12. |
| MLA | Jiang, Kai,et al."A facile and efficient approach for hypertrophic scar therapyviaDNA-based transdermal drug delivery".NANOSCALE 12(2020). |
入库方式： OAI收割
来源：合肥物质科学研究院
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