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Health-related quality of life of patients with colorectal neoplasms in China: A multicenter cross-sectional survey

文献类型：期刊论文

作者Huang, Hui-Yao2,3; Wang, Hong2; Shi, Ju-Fang2; Bai, Ya-Na8; Wang, Le10,11; Liu, Cheng-Cheng2; Yan, Xin-Xin2; Liu, Guo-Xiang12; Liao, Xian-Zhen15; Shi, Dian2,8
刊名JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
出版日期2020-09-22
ISSN号0815-9319
关键词China colorectal neoplasms EQ-5D-3L health-related quality of life (HRQoL) multivariate linear regression
DOI10.1111/jgh.15238
通讯作者Shi, Ju-Fang(shijf@cicams.ac.cn) ; Dai, Min(daimin2002@hotmail.com)
英文摘要Background and Aim This study aimed to clarify health-related quality of life (HRQoL) of patients with colorectal precancer and colorectal cancer (CRC) in China and to better understand related utility scores. Methods A hospital-based cross-sectional survey was conducted in precancer and CRC patients from 2012 to 2014, covering 12 provinces in China. HRQoL was assessed with EuroQol 5-Dimensions 3-Levels. Utility scores were derived using Chinese value set. A multivariate regression model was established to explore potential predictors of utility scores. Results A total of 376 precancer (mean age 58.7 years, 61.2% men) and 2470 CRC patients (mean age 58.6 years, 57.6% men) were included. In five dimensions, there was a certain percentage of problem reported among precancer (range: 12.0% to 36.7%) and CRC (range: 32.4% to 50.3%) patients, with pain/discomfort being the most serious dimension. Utility scores of precancer and CRC patients were 0.870 (95% confidence interval [CI], 0.855-0.886) and 0.751 (95% CI, 0.742-0.759), both of which were lower than those of general Chinese population (0.960 [95% CI, 0.960-0.960]). Utilities for patients at stage I to stage IV were 0.742 (95% CI, 0.715-0.769), 0.722 (95% CI, 0.705-0.740), 0.756 (95% CI, 0.741-0.772), and 0.745 (95% CI, 0.742-0.767), respectively. Multivariate analysis showed that therapeutic regimen, time point of the interview, education, occupation, annual household income, and geographic region were associated with utilities of CRC patients. Conclusion Health-related quality of life of both precancer and CRC patients in China declined considerably. Utility scores differed by sociodemographic and clinical characteristics, and findings of these utilities may facilitate implementation of further cost-utility evaluations.
WOS关键词UTILITY SCORES ; CANCER ; EQ-5D ; VALIDITY ; ANXIETY ; BURDEN ; VALUES
资助项目Chinese Academy of Medical Sciences Innovation Fund for Medical Sciences[2017-I2M-1-006] ; National Natural Science Foundation of China[81773521] ; China Medical Board, Health Policy and System Sciences, Open Competition Grant[19-340] ; Non-profit Central Research Institute Fund of Chinese Academy of Medical Sciences[2018RC330001] ; State Key Projects Specialized on Infectious Diseases[2017ZX10201201-008-002]
WOS研究方向Gastroenterology & Hepatology
语种英语
出版者WILEY
WOS记录号WOS:000571705200001
资助机构Chinese Academy of Medical Sciences Innovation Fund for Medical Sciences ; National Natural Science Foundation of China ; China Medical Board, Health Policy and System Sciences, Open Competition Grant ; Non-profit Central Research Institute Fund of Chinese Academy of Medical Sciences ; State Key Projects Specialized on Infectious Diseases
源URL[http://ir.hfcas.ac.cn:8080/handle/334002/104214]  
专题中国科学院合肥物质科学研究院
通讯作者Shi, Ju-Fang; Dai, Min
作者单位1.Shandong Tumor Hosp, Sci & Educ Dept Publ Hlth Div, Jinan, Peoples R China
2.Chinese Acad Med Sci & Peking Union Med Coll, Natl Clin Res Ctr Canc, Natl Canc Ctr, Off Canc Screening,Canc Hosp, 17 South Panjiayuan Lane, Beijing 100021, Peoples R China
3.Chinese Acad Med Sci & Peking Union Med Coll, Natl Clin Res Ctr Canc, Natl Canc Ctr, Clin Trials Ctr,Canc Hosp, Beijing, Peoples R China
4.Chinese Acad Med Sci & Peking Union Med Coll, Natl Clin Res Ctr Canc, Natl Canc Ctr, Dept Phys Examinat Canc,Canc Hosp, Beijing, Peoples R China
5.Chinese Acad Med Sci & Peking Union Med Coll, Natl Clin Res Ctr Canc, Natl Canc Ctr, Dept Thorac Surg,Canc Hosp, Beijing, Peoples R China
6.Chinese Acad Med Sci, Inst Med Informat, Publ Hlth Informat Res Off, Beijing, Peoples R China
7.Peking Univ, China Ctr Hlth Econ Res, Beijing, Peoples R China
8.Lanzhou Univ, Inst Epidemiol & Hlth Stat, Lanzhou, Peoples R China
9.Gansu Prov Canc Hosp, Canc Epidemiol Res Ctr, Lanzhou, Peoples R China
10.Univ Chinese Acad Sci, Zhejiang Canc Hosp, Canc Hosp, Dept Canc Prevent, Hangzhou, Peoples R China
推荐引用方式
GB/T 7714		 Huang, Hui-Yao,Wang, Hong,Shi, Ju-Fang,et al. Health-related quality of life of patients with colorectal neoplasms in China: A multicenter cross-sectional survey[J]. JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY,2020.
APA Huang, Hui-Yao.,Wang, Hong.,Shi, Ju-Fang.,Bai, Ya-Na.,Wang, Le.,...&He, Jie.(2020).Health-related quality of life of patients with colorectal neoplasms in China: A multicenter cross-sectional survey.JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY.
MLA Huang, Hui-Yao,et al."Health-related quality of life of patients with colorectal neoplasms in China: A multicenter cross-sectional survey".JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY (2020).

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来源：合肥物质科学研究院

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