2019-nCoV may create complications in colon cancer patients with ACE2 expression
文献类型：期刊论文
| 作者 | Chen, Yongyi1,2,3; Gong, Wangang1,2,3; Wei, Haibin1,2,3; Dai, Wumin1,2,3; Xu, Songxiao1,2,3 |
| 刊名 | INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL PATHOLOGY
 |
| 出版日期 | 2020 |
| 卷号 | 13 |
| 关键词 | 2019-nCoV colon cancer ACE2 bioinformatics |
| ISSN号 | 1936-2625 |
| 通讯作者 | Xu, Songxiao(xusx@zjcc.org.cn) |
| 英文摘要 | Since December 2019, a novel coronavirus (2019-nCoV) has emerged from Wuhan, China, causing symptoms in humans. Much remains unknown about 2019-nCoV, especially the additional risks that 2019-nCoV infection may pose for colon cancer patients. Many reports show that angiotensin converting enzyme II (ACE2) is the cell receptor through which 2019-nCoV enters host cells, and this is similar to the cell entry mechanism of SARS coronavirus. Previous studies show that ACE2 is highly expressed in the gastrointestinal tract, especially in the colon. In patients with colon cancer, ACE2 expression is significantly increased in tumor tissues compared to tissues from patients with other types of cancer. One of the known regulators of endocytosis is the serine protease (TMPRSS2) and AP2-associated protein kinase 1 (AAK1), which also facilitates the passage of viruses into cells. Furthermore, the Database of Gene expression profiling interactive analysis suggests that expression levels for ACE2, TMPRSS2, and AAK1 are positively correlated in colon cells. Therefore, our findings predict that 2019-nCoV will create increased complications for patients with colon cancer. |
| WOS研究方向 | Oncology ; Pathology |
| 语种 | 英语 |
| WOS记录号 | WOS:000576775000010 |
| 出版者 | E-CENTURY PUBLISHING CORP |
| 源URL | [http://ir.hfcas.ac.cn:8080/handle/334002/104449]  |
| 专题 | 中国科学院合肥物质科学研究院 |
| 通讯作者 | Xu, Songxiao |
| 作者单位 | 1.Univ Chinese Acad Sci, Canc Hosp, Dept Clin Lab, Hangzhou 310022, Peoples R China 2.Chinese Acad Sci, Inst Canc Res & Basic Med Sci, Hangzhou 310022, Peoples R China 3.Zhejiang Canc Hosp, Dept Clin Lab, 1 East Banshan Rd, Hangzhou 310022, Peoples R China |
| 推荐引用方式 GB/T 7714 | Chen, Yongyi,Gong, Wangang,Wei, Haibin,et al. 2019-nCoV may create complications in colon cancer patients with ACE2 expression[J]. INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL PATHOLOGY,2020,13. |
| APA | Chen, Yongyi,Gong, Wangang,Wei, Haibin,Dai, Wumin,&Xu, Songxiao.(2020).2019-nCoV may create complications in colon cancer patients with ACE2 expression.INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL PATHOLOGY,13. |
| MLA | Chen, Yongyi,et al."2019-nCoV may create complications in colon cancer patients with ACE2 expression".INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL PATHOLOGY 13(2020). |
入库方式： OAI收割
来源：合肥物质科学研究院
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。