Prognostic analysis of recurrence in children and adolescents with differentiated thyroid cancer
文献类型：期刊论文
| 作者 | Wang, Xing1,2; Wang, Xiao-Lei3 |
| 刊名 | CHINESE MEDICAL JOURNAL
 |
| 出版日期 | 2020-10-05 |
| 卷号 | 133 |
| 关键词 | Children and adolescents Differentiated thyroid cancer Recurrence |
| ISSN号 | 0366-6999 |
| DOI | 10.1097/CM9.0000000000000910 |
| 通讯作者 | Wang, Xiao-Lei(wangxlcams@126.com) |
| 英文摘要 | Background: The standard treatment for pediatric differentiated thyroid carcinoma (DTC) still requires consideration because of a lack of clinical evidence. The purpose of this study was to summarize the clinical experiences and explore the risk factors for post-operative recurrence through a retrospective analysis to develop better clinical strategies for pediatric DTC. Methods: This study retrospectively analyzed children and adolescents with DTC who were treated between January 1999 and December 2014 at the Cancer Hospital, Chinese Academy of Medical Sciences. Clinicopathological results and outcomes were collected. A log-rank test of Kaplan-Meier curves and the Cox regression model were used to determine the factors associated with recurrence. Results: Data of 150 patients were collected in this study. During the follow-up, there was only one disease-related death. The recurrence rates at 3, 5, and 10 years were 13.6%, 18.7%, and 28.6%, respectively. There was a significant difference in the rate of recurrence according to age (P < 0.001), extrathyroidal extension (P < 0.001), lymph node metastasis (P = 0.023), and invasion of the trachea and esophageal wall (P = 0.004). Cox regression analysis demonstrated that age (P = 0.006) and extrathyroidal extension (P = 0.013) were significant dependent factors of post-operative recurrence. Conclusions: The prognosis of DTC in children and adolescents is favorable. A close follow-up is recommended because of the high recurrence rate. A comparatively higher recurrence rate was observed in the younger age group, and new age-based divisions may be needed to conveniently evaluate the possibility of recurrence. |
| WOS关键词 | PREDICTIVE FACTORS ; CARCINOMA ; COMPLICATIONS ; DISEASE |
| WOS研究方向 | General & Internal Medicine |
| 语种 | 英语 |
| WOS记录号 | WOS:000577959000004 |
| 出版者 | LIPPINCOTT WILLIAMS & WILKINS |
| 源URL | [http://ir.hfcas.ac.cn:8080/handle/334002/104563]  |
| 专题 | 中国科学院合肥物质科学研究院 |
| 通讯作者 | Wang, Xiao-Lei |
| 作者单位 | 1.Univ Chinese Acad Sci, Zhejiang Canc Hosp, Canc Hosp, Dept Head & Neck Surg, Hangzhou 310022, Zhejiang, Peoples R China 2.Chinese Acad Sci, Inst Canc & Basic Med ICBM, Hangzhou 310022, Zhejiang, Peoples R China 3.Chinese Acad Med Sci & Peking Union Med Coll, Canc Hosp, Natl Clin Res Ctr Canc, Dept Head Neck Surg,Natl Canc Ctr, Beijing 100021, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wang, Xing,Wang, Xiao-Lei. Prognostic analysis of recurrence in children and adolescents with differentiated thyroid cancer[J]. CHINESE MEDICAL JOURNAL,2020,133. |
| APA | Wang, Xing,&Wang, Xiao-Lei.(2020).Prognostic analysis of recurrence in children and adolescents with differentiated thyroid cancer.CHINESE MEDICAL JOURNAL,133. |
| MLA | Wang, Xing,et al."Prognostic analysis of recurrence in children and adolescents with differentiated thyroid cancer".CHINESE MEDICAL JOURNAL 133(2020). |
入库方式： OAI收割
来源：合肥物质科学研究院
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。