Biodegradable ternary Zn-3Ge-0.5X (X=Cu, Mg, and Fe) alloys for orthopedic applications
文献类型：期刊论文
| 作者 | Lin, Jixing1,2; Tong, Xian1,2; Sun, Quanxiang2; Luan, Yanan3; Zhang, Dechuang2; Shi, Zimu4 ; Wang, Kun1; Lin, Jianguo2; Li, Yuncang5; Dargusch, Matthew6
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| 刊名 | ACTA BIOMATERIALIA
 |
| 出版日期 | 2020-10-01 |
| 卷号 | 115 |
| ISSN号 | 1742-7061 |
| 关键词 | Cytotoxicity Degradation behavior Mechanical properties Zn-Ge biodegradable metals |
| DOI | 10.1016/j.actbio.2020.08.033 |
| 通讯作者 | Lin, Jixing(linjixing@163.com) ; Zhang, Dechuang(dczhang@xtu.edu.cn) ; Wen, Cuie(cuie.wen@rmit.edu.au) |
| 英文摘要 | Biodegradable zinc (Zn) and its alloys have great potential to be used for orthopedic applications due to their suitable degradation rate and good biocompatibility. However, pure Zn has insufficient mechanical properties, such as low strength and hardness, and poor plasticity, which limits its clinical applications. Here, we report on a new series of ternary Zn-3Ge-0.5X (X-Cu, Mg, and Fe) alloys aiming to achieve good corrosion resistance and biocompatibility, and enhanced mechanical properties via micro-alloying with copper (Cu), magnesium (Mg), and iron (Fe). Hot-rolling has also been applied to the new ternary alloys to further enhance their mechanical properties. Mechanical testing results indicate that both the strength and hardness of hot-rolled Zn-3Ge are significantly improved with micro-alloying of Cu, Mg, and Fe; of which the hot-rolled Zn-3Ge-0.5Mg exhibits the highest ultimate tensile strength of 253.4 MPa and yield strength of 208.5 MPa among all the alloys, 25.9% and 44.7% higher than those of the hot-rolled Zn-3Ge. The degradation rate of the as-cast alloys is lower than that of the hot-rolled alloys in Hanks' solution for 1 month and the hot-rolled Zn-3Ge-0.5Mg alloy exhibits the highest degradation rate of 0.075 mm/y. CCK-8 assay using MG-63 cells indicates that the diluted extracts of Zn-3Ge-0.5X (X-Cu, Mg, and Fe) alloys with concentrations of 12.5% and 25% exhibit no or slight cytotoxicity, and the diluted extracts of Zn-3Ge-0.5Cu alloys show high cell viability of over 100%, showing the best cytocompatibility. (C) 2020 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved. |
| WOS关键词 | IN-VITRO DEGRADATION ; ZN-BASED ALLOYS ; MECHANICAL-PROPERTIES ; ZINC-DEFICIENCY ; CYTOTOXICITY EVALUATION ; CORROSION BEHAVIOR ; PROTECTIVE ROLE ; TRACE-ELEMENTS ; BINARY-ALLOYS ; MICROSTRUCTURE |
| 资助项目 | Wenzhou Science and Technology Bureau[ZG2019022] ; Wenzhou Science and Technology Bureau[2018ZG008] ; Australian Research Council (ARC)[DP170102557] ; Australian Research Council (ARC)[FT160100252] ; ARC Research Hub for Advanced Manufacturing of Medical Devices[IH15010 0 024] ; National Natural Science Foundation of China[11872053] ; National Natural Science Foundation of China[51971190] ; Scientific Research Fund of Hunan Provincial Science and Technology Department[2018JJ4053] ; Scientific Research Fund of Hunan Provincial Science and Technology Department[18A065] |
| WOS研究方向 | Engineering ; Materials Science |
| 语种 | 英语 |
| 出版者 | ELSEVIER SCI LTD |
| WOS记录号 | WOS:000577511200033 |
| 资助机构 | Wenzhou Science and Technology Bureau ; Australian Research Council (ARC) ; ARC Research Hub for Advanced Manufacturing of Medical Devices ; National Natural Science Foundation of China ; Scientific Research Fund of Hunan Provincial Science and Technology Department |
| 源URL | [http://ir.hfcas.ac.cn:8080/handle/334002/104669]  |
| 专题 | 中国科学院合肥物质科学研究院 |
| 通讯作者 | Lin, Jixing; Zhang, Dechuang; Wen, Cuie |
| 作者单位 | 1.Zhejiang Ind & Trade Vocat Coll, Dept Mat Engn, Wenzhou 325003, Peoples R China 2.Xiangtan Univ, Sch Mat Sci & Engn, Xiangtan 411105, Peoples R China 3.Beijing Univ Technol, Coll Environm & Energy Engn, Beijing 100000, Peoples R China 4.Chinese Acad Sci, Inst Solid State Phys, Key Lab Mat Phys, Hefei 230031, Peoples R China 5.RMIT Univ, Sch Engn, Melbourne, Vic 3001, Australia 6.Univ Queensland, Ctr Adv Mat Proc & Mfg AMPAM, Brisbane, Qld 4072, Australia |
| 推荐引用方式 GB/T 7714 | Lin, Jixing,Tong, Xian,Sun, Quanxiang,et al. Biodegradable ternary Zn-3Ge-0.5X (X=Cu, Mg, and Fe) alloys for orthopedic applications[J]. ACTA BIOMATERIALIA,2020,115. |
| APA | Lin, Jixing.,Tong, Xian.,Sun, Quanxiang.,Luan, Yanan.,Zhang, Dechuang.,...&Wen, Cuie.(2020).Biodegradable ternary Zn-3Ge-0.5X (X=Cu, Mg, and Fe) alloys for orthopedic applications.ACTA BIOMATERIALIA,115. |
| MLA | Lin, Jixing,et al."Biodegradable ternary Zn-3Ge-0.5X (X=Cu, Mg, and Fe) alloys for orthopedic applications".ACTA BIOMATERIALIA 115(2020). |
入库方式： OAI收割
来源：合肥物质科学研究院
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