Chemical protein synthesis-assisted high-throughput screening strategies for D-peptides in drug discovery
文献类型：期刊论文
| 作者 | Li, Ying1; Cao, Xiuxiu2; Tian, Changlin1,2; Zheng, Ji-Shen1 |
| 刊名 | CHINESE CHEMICAL LETTERS
 |
| 出版日期 | 2020-09-01 |
| 卷号 | 31 |
| 关键词 | Chemical protein synthesis Mirror-image proteins Mirror-image phage display Mirror-image one-bead one-compound (OBOC) D-Peptide drug |
| ISSN号 | 1001-8417 |
| DOI | 10.1016/j.cclet.2020.04.015 |
| 通讯作者 | Zheng, Ji-Shen(jszheng@ustc.edu.cn) |
| 英文摘要 | D-peptides are recognized as a new class of synthetic chemical drugs and they possess many interesting advantages such as high enzymatic stability, improved oral bioavailability, as well as high binding affinity and specificity. Recently, D-peptide drugs have been attracting increasing attention in both academic and industrial researches over recent years. One D-peptide etelcalcetide has even entered the market that targets the calcium (Ca2+)-sensing receptor (CaSR) to fight secondary hyperparathyroidism. Effective discovery and optimization of D-peptide ligands that can bind to various disease-related targets with high specificity and potency is of great importance for the development of D-peptide drugs. This review surveys the recent method development in this area especially the chemical protein synthesis-assisted high-throughput screening strategies for D-peptide ligands and their application in drug discovery. (C) 2020 Chinese Chemical Society and Institute of Materia Medica, Chinese Academy of Medical Sciences. Published by Elsevier B.V. All rights reserved. |
| WOS关键词 | IMAGE PHAGE DISPLAY ; BRAIN-BARRIER PENETRATION ; X-RAY STRUCTURES ; MIRROR-IMAGE ; PHARMACOKINETIC PROPERTIES ; MEMBRANE-PROTEINS ; UBIQUITIN CHAINS ; COILED-COIL ; HIV-1 ENTRY ; INHIBITORS |
| 资助项目 | National Key R&D Program of China[2019YFA0706902] ; National Natural Science Foundation of China[U1732161] ; National Natural Science Foundation of China[91753120] ; Science and Technological Fund of Anhui Province for Outstanding Youth[1808085J04] |
| WOS研究方向 | Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:000582384200037 |
| 出版者 | ELSEVIER SCIENCE INC |
| 资助机构 | National Key R&D Program of China ; National Natural Science Foundation of China ; Science and Technological Fund of Anhui Province for Outstanding Youth |
| 源URL | [http://ir.hfcas.ac.cn:8080/handle/334002/104826]  |
| 专题 | 中国科学院合肥物质科学研究院 |
| 通讯作者 | Zheng, Ji-Shen |
| 作者单位 | 1.Univ Sci & Technol China, Sch Life Sci, Dept Chem, Hefei Natl Lab Phys Sci Microscale, Hefei 230027, Peoples R China 2.Chinese Acad Sci, High Magnet Field Lab, Hefei 230031, Peoples R China |
| 推荐引用方式 GB/T 7714 | Li, Ying,Cao, Xiuxiu,Tian, Changlin,et al. Chemical protein synthesis-assisted high-throughput screening strategies for D-peptides in drug discovery[J]. CHINESE CHEMICAL LETTERS,2020,31. |
| APA | Li, Ying,Cao, Xiuxiu,Tian, Changlin,&Zheng, Ji-Shen.(2020).Chemical protein synthesis-assisted high-throughput screening strategies for D-peptides in drug discovery.CHINESE CHEMICAL LETTERS,31. |
| MLA | Li, Ying,et al."Chemical protein synthesis-assisted high-throughput screening strategies for D-peptides in drug discovery".CHINESE CHEMICAL LETTERS 31(2020). |
入库方式： OAI收割
来源：合肥物质科学研究院
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