ULK1 inhibitor induces spindle microtubule disorganization and inhibits phosphorylation of Ser10 of histone H3
文献类型：期刊论文
| 作者 | Ji, Xinmiao2; Zhang, Xin1,2 ; Li, Zhiyuan2
|
| 刊名 | FEBS OPEN BIO
 |
| 出版日期 | 2020-11-01 |
| 卷号 | 10 |
| ISSN号 | 2211-5463 |
| 关键词 | autophagy mitosis MRT68921 polyploidy SBI‐ 0206965 ULK1 inhibitor |
| DOI | 10.1002/2211-5463.13000 |
| 通讯作者 | Li, Zhiyuan(lizhiyuan@hmfl.ac.cn) |
| 英文摘要 | Certain tumors are dependent on autophagy for survival; thus, the use of unc-51-like autophagy activating kinase (ULK) 1 inhibitors to block autophagy has the potential for tumor treatment. However, ULK1 inhibitors affect processes other than autophagy. Herein, we report that the ULK1 inhibitors SBI-0206965/MRT68921 not only inhibit phosphorylation of histone H3 (Ser10) and delay chromatin condensation but also induce spindle microtubule disorganization to form short and fragmented microtubule polymers. Although the delay in chromatin condensation also delayed mitotic entry, the disorganized microtubule polymers resulted in unsegregated chromosomes and polyploidy. Although the effect on mitotic entry was moderate, polyploidy formation was decreased in ULK1 knockout cells with or without ULK2 knockdown. In conclusion, it will be helpful to consider the roles of ULK1 inhibitors in mitotic dysregulation, as well as autophagy, when evaluating their antitumor efficacy. |
| WOS关键词 | AURORA-B ; AUTOPHAGY ; CELLS ; AMPK ; APOPTOSIS ; KINASES ; COMPLEX ; MITOSIS ; GROWTH ; ENTRY |
| WOS研究方向 | Biochemistry & Molecular Biology |
| 语种 | 英语 |
| 出版者 | WILEY |
| WOS记录号 | WOS:000584406700017 |
| 源URL | [http://ir.hfcas.ac.cn:8080/handle/334002/104857]  |
| 专题 | 中国科学院合肥物质科学研究院 |
| 通讯作者 | Li, Zhiyuan |
| 作者单位 | 1.Anhui Univ, Inst Phys Sci & Informat Technol, Hefei, Peoples R China 2.Chinese Acad Sci, Hefei Inst Phys Sci, High Magnet Field Lab, Key Lab High Magnet Field & Ion Beam Phys Biol, Hefei 230031, Anhui, Peoples R China |
| 推荐引用方式 GB/T 7714 | Ji, Xinmiao,Zhang, Xin,Li, Zhiyuan. ULK1 inhibitor induces spindle microtubule disorganization and inhibits phosphorylation of Ser10 of histone H3[J]. FEBS OPEN BIO,2020,10. |
| APA | Ji, Xinmiao,Zhang, Xin,&Li, Zhiyuan.(2020).ULK1 inhibitor induces spindle microtubule disorganization and inhibits phosphorylation of Ser10 of histone H3.FEBS OPEN BIO,10. |
| MLA | Ji, Xinmiao,et al."ULK1 inhibitor induces spindle microtubule disorganization and inhibits phosphorylation of Ser10 of histone H3".FEBS OPEN BIO 10(2020). |
入库方式： OAI收割
来源：合肥物质科学研究院
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