Polo-like kinase 1 coordinates biosynthesis during cell cycle progression by directly activating pentose phosphate pathway
文献类型:期刊论文
作者 | Ma, Xiaoyu4; Wang, Lin4; Huang, De4; Li, Yunyan5; Yang, Dongdong4; Li, Tingting4; Li, Fudong1,3; Sun, Linchong4; Wei, Haoran4; He, Kun2 |
刊名 | NATURE COMMUNICATIONS |
出版日期 | 2017-11-15 |
卷号 | 8期号:无页码:15 |
ISSN号 | 2041-1723 |
DOI | 10.1038/s41467-017-01647-5 |
英文摘要 | Two hallmarks for cancer cells are the accelerated cell cycle progression as well as the altered metabolism, however, how these changes are coordinated to optimize the growth advantage for cancer cells are still poorly understood. Here we identify that Polo-like kinase 1 (Plk1), a key regulator for cell mitosis, plays a critical role for biosynthesis in cancer cells through activating pentose phosphate pathway (PPP). We find that Plk1 interacts with and directly phosphorylates glucose-6-phosphate dehydrogenase (G6PD). By activating G6PD through promoting the formation of its active dimer, Plk1 increases PPP flux and directs glucose to the synthesis of macromolecules. Importantly, we further demonstrate that Plk1-mediated activation of G6PD is critical for its role to promote cell cycle progression and cancer cell growth. Collectively, these findings establish a critical role for Plk1 in regulating biosynthesis in cancer cells, exemplifying how cell cycle progression and metabolic reprogramming are coordinated for cancer progression. |
WOS关键词 | HUMAN GLUCOSE-6-PHOSPHATE-DEHYDROGENASE ; CANCER PROGRESSION ; POLO-LIKE-KINASE-1 PLK1 ; METABOLIC-REGULATION ; GLUCOSE-METABOLISM ; DNA-REPLICATION ; MOLECULAR-BASIS ; PROLIFERATION ; PHOSPHORYLATION ; CHECKPOINTS |
资助项目 | Ministry of Science and Technology of China[2014CB910600] ; Ministry of Science and Technology of China[2017YFA0205600] ; National Natural Science Foundation of China[81530076] ; National Natural Science Foundation of China[81525022] ; National Natural Science Foundation of China[31371429] ; National Natural Science Foundation of China[81372148] ; National Natural Science Foundation of China[31571472] ; National Natural Science Foundation of China[81502395] |
WOS研究方向 | Science & Technology - Other Topics |
语种 | 英语 |
出版者 | NATURE PUBLISHING GROUP |
WOS记录号 | WOS:000415262100007 |
源URL | [http://ir.hfcas.ac.cn:8080/handle/334002/34821] |
专题 | 合肥物质科学研究院_中科院强磁场科学中心 |
通讯作者 | Wang, Junfeng; Gao, Ping; Zhang, Huafeng |
作者单位 | 1.Univ Sci & Technol China, Hefei Natl Lab Phys Sci Microscale, Hefei 230027, Anhui, Peoples R China 2.Natl Ctr Biomed Anal, Inst Basic Med Sci, Beijing 100850, Peoples R China 3.Univ Sci & Technol China, Sch Life Sci, Hefei 230027, Anhui, Peoples R China 4.Univ Sci & Technol China, Hefei Natl Lab Phys Sci Microscale, CAS Key Lab Innate Immun & Chron Dis, Innovat Ctr Cell Signaling Network,Sch Life Sci, Hefei 230027, Anhui, Peoples R China 5.Chinese Acad Sci, High Field Magnet Lab, 350 Shushanhu Rd, Hefei 230031, Anhui, Peoples R China |
推荐引用方式 GB/T 7714 | Ma, Xiaoyu,Wang, Lin,Huang, De,et al. Polo-like kinase 1 coordinates biosynthesis during cell cycle progression by directly activating pentose phosphate pathway[J]. NATURE COMMUNICATIONS,2017,8(无):15. |
APA | Ma, Xiaoyu.,Wang, Lin.,Huang, De.,Li, Yunyan.,Yang, Dongdong.,...&Zhang, Huafeng.(2017).Polo-like kinase 1 coordinates biosynthesis during cell cycle progression by directly activating pentose phosphate pathway.NATURE COMMUNICATIONS,8(无),15. |
MLA | Ma, Xiaoyu,et al."Polo-like kinase 1 coordinates biosynthesis during cell cycle progression by directly activating pentose phosphate pathway".NATURE COMMUNICATIONS 8.无(2017):15. |
入库方式: OAI收割
来源:合肥物质科学研究院
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