Racemic X-ray structure of L-type calcium channel antagonist Calciseptine prepared by total chemical synthesis
文献类型：期刊论文
| 作者 | Chen, Chen-Chen1,3; Gao, Shuai4; Ai, Hua-Song4; Qu, Qian2,4; Tian, Chang-Lin1,3 ; Li, Yi-Ming2
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| 刊名 | SCIENCE CHINA-CHEMISTRY
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| 出版日期 | 2018-06-01 |
| 卷号 | 61期号:6页码:702-707 |
| 关键词 | protein chemical synthesis calciseptine hydrazide based native chemical ligation racemic protein crystallography |
| ISSN号 | 1674-7291 |
| DOI | 10.1007/s11426-017-9198-y |
| 英文摘要 | Snake toxin Calciseptine as a natural antagonist of L-type calcium channel has potential drug values, but its structural information remains unknown. Here, we report the total chemical synthesis of Calciseptine by using hydrazide based native chemical ligation. The crystal structure of Calciseptine was determined by racemic protein crystallography technique. Compared to the structure of its homologous family protein, we found that Calciseptine is adopting a typical three-finger structure. |
| WOS关键词 | BLACK MAMBA VENOM ; PROTEIN CRYSTALLOGRAPHY ; PEPTIDE HYDRAZIDES ; BLOCKING ACTIVITY ; SHK TOXIN ; LIGATION ; RESIDUES ; BINDING ; SITE ; CHANNELOPATHIES |
| 资助项目 | National Natural Science Foundation of China[21572043] ; National Natural Science Foundation of China[21473176] ; Ministry of Science and Technology[2016YFA0400900] ; Ministry of Science and Technology[2015CB910103] ; Fundamental Research Funds for the Central Universities[PA2017GDQT0021] |
| WOS研究方向 | Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:000434719100013 |
| 出版者 | SCIENCE PRESS |
| 源URL | [http://ir.hfcas.ac.cn:8080/handle/334002/36464]  |
| 专题 | 合肥物质科学研究院_中科院强磁场科学中心 |
| 通讯作者 | Tian, Chang-Lin; Li, Yi-Ming |
| 作者单位 | 1.Chinese Acad Sci, High Field Magnet Lab, Hefei 230031, Anhui, Peoples R China 2.Hefei Univ Technol, Sch Biol & Med Engn, Hefei 230009, Anhui, Peoples R China 3.Univ Sci & Technol China, Sch Life Sci, Hefei 230026, Anhui, Peoples R China 4.Tsinghua Univ, Dept Chem, Beijing 100084, Peoples R China |
| 推荐引用方式 GB/T 7714 | Chen, Chen-Chen,Gao, Shuai,Ai, Hua-Song,et al. Racemic X-ray structure of L-type calcium channel antagonist Calciseptine prepared by total chemical synthesis[J]. SCIENCE CHINA-CHEMISTRY,2018,61(6):702-707. |
| APA | Chen, Chen-Chen,Gao, Shuai,Ai, Hua-Song,Qu, Qian,Tian, Chang-Lin,&Li, Yi-Ming.(2018).Racemic X-ray structure of L-type calcium channel antagonist Calciseptine prepared by total chemical synthesis.SCIENCE CHINA-CHEMISTRY,61(6),702-707. |
| MLA | Chen, Chen-Chen,et al."Racemic X-ray structure of L-type calcium channel antagonist Calciseptine prepared by total chemical synthesis".SCIENCE CHINA-CHEMISTRY 61.6(2018):702-707. |
入库方式： OAI收割
来源：合肥物质科学研究院
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