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In Situ One-Pot Synthesis of MOF-Polydopamine Hybrid Nanogels with Enhanced Photothermal Effect for Targeted Cancer Therapy

文献类型：期刊论文

作者Wang, Dongdong1; Wu, Huihui4; Zhou, Jiajia4; Xu, Pengping1; Wang, Changlai1; Shi, Ruohong1; Wang, Haibao; Wang, Hui2,3; Guo, Zhen4; Chen, Qianwang1,2
刊名ADVANCED SCIENCE
出版日期2018-06-01
卷号5期号:6页码:8
关键词cancer theranostics metal-organic framework-polymer multimodal imaging nanogels photothermal effects
ISSN号2198-3844
DOI10.1002/advs.201800287
通讯作者Wang, Hui(hw39@hmfl.ac.cn) ; Guo, Zhen(zhenguo@ustc.edu.cn) ; Chen, Qianwang(cqw@ustc.edu.cn)
英文摘要Herein, a simple one-pot way is designed to prepare a type of multifunctional metal-organic framework (MOF)-based hybrid nanogels by in situ hybridization of dopamine monomer in the skeleton of MnCo. The resultant hybrid nanoparticles (named as MCP) show enhanced photothermal conversion efficiency in comparison with pure polydopamine or MnCo nanoparticles (NPs) synthesized under a similar method and, therefore, show great potential for photothermal therapy (PTT) in vivo. The MCP NPs are expected to possess T-1 positive magnetic resonance imaging ability due to the high-spin Mn-N6 (S = 5/2) in the skeleton of MnCo. To improve the therapy efficiency as a PTT agent, the MCP NPs are further modified with functional polyethylene glycol (PEG) and thiol terminal cyclic arginine-glycine-aspartic acid peptide, respectively: the first one is to increase the stability, biocompatibility, and blood circulation time of MCP NPs in vivo; the second one is to increase the tumor accumulation of MCP-PEG NPs and improve their therapeutic efficiency as photothermal agent.
WOS关键词DRUG-DELIVERY ; PRUSSIAN BLUE ; MAGNETIC-RESONANCE ; THERANOSTIC APPLICATIONS ; BIOMEDICAL APPLICATIONS ; ORGANIC NANOPARTICLES ; TUMOR VASCULATURE ; CONTRAST AGENTS ; VIVO ; FRAMEWORK
资助项目National Natural Science Foundation of China[21571168] ; Most Grant[2016YFA0101202] ; Most Grant[U1232211] ; CAS/SAFEA international partnership program for creative research teams ; CAS Hefei Science Center[2016HSC-IU011]
WOS研究方向Chemistry ; Science & Technology - Other Topics ; Materials Science
语种英语
WOS记录号WOS:000435765900026
出版者WILEY
资助机构National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; 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源URL[http://ir.hfcas.ac.cn:8080/handle/334002/37165]  
专题合肥物质科学研究院_中科院强磁场科学中心
通讯作者Wang, Hui; Guo, Zhen; Chen, Qianwang
作者单位1.Univ Sci & Technol China, Dept Mat Sci & Engn, Hefei Natl Lab Phys Sci Microscale, Hefei 230026, AH, Peoples R China
2.Univ Sci & Technol China, Anhui Key Lab Condensed Matter Phys Extreme Condi, High Field Magnet Lab, Hefei Inst Phys Sci, Hefei 230031, AH, Peoples R China
3.Anhui Med Univ, Dept Radiol, Affiliated Hosp 1, Hefei 230022, Peoples R China
4.Univ Sci & Technol China, Sch Life Sci, Hefei 230026, AH, Peoples R China
推荐引用方式
GB/T 7714		 Wang, Dongdong,Wu, Huihui,Zhou, Jiajia,et al. In Situ One-Pot Synthesis of MOF-Polydopamine Hybrid Nanogels with Enhanced Photothermal Effect for Targeted Cancer Therapy[J]. ADVANCED SCIENCE,2018,5(6):8.
APA Wang, Dongdong.,Wu, Huihui.,Zhou, Jiajia.,Xu, Pengping.,Wang, Changlai.,...&Chen, Qianwang.(2018).In Situ One-Pot Synthesis of MOF-Polydopamine Hybrid Nanogels with Enhanced Photothermal Effect for Targeted Cancer Therapy.ADVANCED SCIENCE,5(6),8.
MLA Wang, Dongdong,et al."In Situ One-Pot Synthesis of MOF-Polydopamine Hybrid Nanogels with Enhanced Photothermal Effect for Targeted Cancer Therapy".ADVANCED SCIENCE 5.6(2018):8.

入库方式： OAI收割

来源：合肥物质科学研究院

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