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  2. 合肥物质科学研究院
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  4. 中科院强磁场科学中心
Dopamine Receptor Subtypes Differentially Regulate Autophagy

文献类型：期刊论文

作者Wang, Dongmei2,3; Ji, Xinmiao2; Liu, Juanjuan2; Li, Zhiyuan2; Zhang, Xin1,2
刊名INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
出版日期2018-05-01
卷号19期号:5页码:16
关键词dopamine receptor autophagy AKT mTOR AMPK
ISSN号1422-0067
DOI10.3390/ijms19051540
通讯作者Li, Zhiyuan(lizhiyuan@hmfl.ac.cn) ; Zhang, Xin(xinzhang@hmfl.ac.cn)
英文摘要Some dopamine receptor subtypes were reported to participate in autophagy regulation, but their exact functions and mechanisms are still unclear. Here we found that dopamine receptors D2 and D3 (D2-like family) are positive regulators of autophagy, while dopamine receptors D1 and D5 (D1-like family) are negative regulators. Furthermore, dopamine and ammonia, the two reported endogenous ligands of dopamine receptors, both can induce dopamine receptor internalization and degradation. In addition, we found that AKT (protein kinase B)-mTOR (mechanistic target of rapamycin) and AMPK (AMP-activated protein kinase) pathways are involved in DRD3 (dopamine receptor D3) regulated autophagy. Moreover, autophagy machinery perturbation inhibited DRD3 degradation and increased DRD3 oligomer. Therefore, our study investigated the functions and mechanisms of dopamine receptors in autophagy regulation, which not only provides insights into better understanding of some dopamine receptor-related neurodegeneration diseases, but also sheds light on their potential treatment in combination with autophagy or mTOR pathway modulations.
WOS关键词PROTEIN-COUPLED RECEPTORS ; INDUCED ENDOCYTOSIS ; D-3 RECEPTORS ; D2 RECEPTORS ; ACTIVATION ; MTOR ; PHOSPHORYLATION ; DISEASE ; KINASE ; GROWTH
资助项目China Postdoctoral Science Foundation[2016M602045] ; Chinese Academy of Sciences ; National Key Research and Development Program of China[2016YFA0400900]
WOS研究方向Biochemistry & Molecular Biology ; Chemistry
语种英语
WOS记录号WOS:000435297000276
出版者MDPI
资助机构China Postdoctoral Science Foundation ; China Postdoctoral Science Foundation ; China Postdoctoral Science Foundation ; China Postdoctoral Science Foundation ; China Postdoctoral Science Foundation ; China Postdoctoral Science Foundation ; China Postdoctoral Science Foundation ; China Postdoctoral Science Foundation ; China Postdoctoral Science Foundation ; China Postdoctoral Science Foundation ; China Postdoctoral Science Foundation ; China Postdoctoral Science Foundation ; China Postdoctoral Science Foundation ; China Postdoctoral Science Foundation ; China Postdoctoral Science Foundation ; China Postdoctoral Science Foundation ; China Postdoctoral Science Foundation ; China Postdoctoral Science Foundation ; China Postdoctoral Science Foundation ; China Postdoctoral Science Foundation ; China Postdoctoral Science Foundation ; China Postdoctoral Science Foundation ; China Postdoctoral Science Foundation ; China Postdoctoral Science Foundation ; China Postdoctoral Science Foundation ; 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源URL[http://ir.hfcas.ac.cn:8080/handle/334002/37180]  
专题合肥物质科学研究院_中科院强磁场科学中心
通讯作者Li, Zhiyuan; Zhang, Xin
作者单位1.Anhui Univ, Inst Phys Sci & Informat Technol, Hefei 230601, Anhui, Peoples R China
2.Chinese Acad Sci, Hefei Inst Phys Sci, High Field Magnet Lab, Key Lab High Magnet Field & Ion Beam Phys Biol, Hefei 230031, Peoples R China
3.Univ Sci & Technol China, Grad Sch, Sci Isl Branch, Hefei 230031, Peoples R China
推荐引用方式
GB/T 7714		 Wang, Dongmei,Ji, Xinmiao,Liu, Juanjuan,et al. Dopamine Receptor Subtypes Differentially Regulate Autophagy[J]. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES,2018,19(5):16.
APA Wang, Dongmei,Ji, Xinmiao,Liu, Juanjuan,Li, Zhiyuan,&Zhang, Xin.(2018).Dopamine Receptor Subtypes Differentially Regulate Autophagy.INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES,19(5),16.
MLA Wang, Dongmei,et al."Dopamine Receptor Subtypes Differentially Regulate Autophagy".INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 19.5(2018):16.

入库方式： OAI收割

来源：合肥物质科学研究院

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