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  4. 中科院强磁场科学中心
Composition-dependent membrane disruption by the proapoptotic protein PB1F2 from HK97 influenza A virus

文献类型：期刊论文

作者Wang, Yujuan1,2; Yang, Jing1,2; Wang, Jiarong1,2; Zhu, Lei1,2; Wang, Junfeng1,2,3
刊名FEBS LETTERS
出版日期2018-08-01
卷号592期号:15页码:2572-2581
关键词influenza A virus membrane disruption micelle-like lipid assembly NMR PB1F2
ISSN号1873-3468
DOI10.1002/1873-3468.13172
通讯作者Wang, Yujuan(Yjwang@hmfl.ac.cn) ; Wang, Junfeng(Junfeng@hmfl.ac.cn)
英文摘要PBIF2 is a proapoptotic protein encoded by an alternative reading frame in the influenza A virus. Its accumulation accelerates mitochondrial fragmentation by decreasing the mitochondrial membrane potential following translocation into the mitochondrial inner membrane space, but the mechanistic underpinnings remain unclear. Herein, the PB1F2 from HK97 was expressed and purified in soluble form. The interaction between PBIF2 and the mitochondrial membrane were investigated using three membrane mimics, liposomes, bicelles, and nanodiscs. We show that the interactions between PBIF2 and membrane mimics depend on lipid type and are time- and dose-dependent. The primary membrane target of PBIF2 is phosphatidylcholine, the lipid that forms the major component of mitochondria! inner membranes. PBIF2 disrupts the integrity of lipid membranes by forming micelle-like PBIF2-lipid assemblies.
WOS关键词PB1-F2 PROTEIN ; MITOCHONDRIAL-MEMBRANE ; PORE FORMATION ; DAMAGE ; OLIGOMERS ; DOMAIN ; BETA
资助项目National Natural Science Foundation of China[31200579] ; National Natural Science Foundation of China[21473210] ; National Natural Science Foundation of China[21502196] ; National Natural Science Foundation of China[U1532269] ; Innovative Program of Development Foundation of Hefei Center for Physical Science and Technology[2016FXCX005]
WOS研究方向Biochemistry & Molecular Biology ; Biophysics ; Cell Biology
语种英语
WOS记录号WOS:000441436400007
出版者WILEY
资助机构National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Innovative Program of Development Foundation of Hefei Center for Physical Science and Technology ; Innovative Program of Development Foundation of Hefei Center for Physical Science and Technology ; Innovative Program of Development Foundation of Hefei Center for Physical Science and Technology ; Innovative Program of Development Foundation of Hefei Center for Physical Science and Technology ; Innovative Program of Development Foundation of Hefei Center for Physical Science and Technology ; Innovative Program of Development Foundation of Hefei Center for Physical Science and Technology ; 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National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Innovative Program of Development Foundation of Hefei Center for Physical Science and Technology ; Innovative Program of Development Foundation of Hefei Center for Physical Science and Technology ; Innovative Program of Development Foundation of Hefei Center for Physical Science and Technology ; Innovative Program of Development Foundation of Hefei Center for Physical Science and Technology ; Innovative Program of Development Foundation of Hefei Center for Physical Science and Technology ; Innovative Program of Development Foundation of Hefei Center for Physical Science and Technology ; Innovative Program of Development Foundation of Hefei Center for Physical Science and Technology ; Innovative Program of Development Foundation of Hefei Center for Physical Science and Technology ; Innovative Program of Development Foundation of Hefei Center for Physical Science and Technology ; Innovative Program of Development Foundation of Hefei Center for Physical Science and Technology ; Innovative Program of Development Foundation of Hefei Center for Physical Science and Technology ; Innovative Program of Development Foundation of Hefei Center for Physical Science and Technology ; Innovative Program of Development Foundation of Hefei Center for Physical Science and Technology ; 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Innovative Program of Development Foundation of Hefei Center for Physical Science and Technology ; Innovative Program of Development Foundation of Hefei Center for Physical Science and Technology ; Innovative Program of Development Foundation of Hefei Center for Physical Science and Technology ; Innovative Program of Development Foundation of Hefei Center for Physical Science and Technology ; Innovative Program of Development Foundation of Hefei Center for Physical Science and Technology ; Innovative Program of Development Foundation of Hefei Center for Physical Science and Technology ; Innovative Program of Development Foundation of Hefei Center for Physical Science and Technology ; Innovative Program of Development Foundation of Hefei Center for Physical Science and Technology
源URL[http://ir.hfcas.ac.cn:8080/handle/334002/37694]  
专题合肥物质科学研究院_中科院强磁场科学中心
通讯作者Wang, Yujuan; Wang, Junfeng
作者单位1.Chinese Acad Sci, Hefei Inst Phys Sci, High Field Magnet Lab, Hefei, Anhui, Peoples R China
2.Chinese Acad Sci, Key Lab High Magnet Field & Ion Beam Phys Biol, Hefei, Anhui, Peoples R China
3.Anhui Univ, Inst Phys Sci & Informat Technol, Hefei, Anhui, Peoples R China
推荐引用方式
GB/T 7714		 Wang, Yujuan,Yang, Jing,Wang, Jiarong,et al. Composition-dependent membrane disruption by the proapoptotic protein PB1F2 from HK97 influenza A virus[J]. FEBS LETTERS,2018,592(15):2572-2581.
APA Wang, Yujuan,Yang, Jing,Wang, Jiarong,Zhu, Lei,&Wang, Junfeng.(2018).Composition-dependent membrane disruption by the proapoptotic protein PB1F2 from HK97 influenza A virus.FEBS LETTERS,592(15),2572-2581.
MLA Wang, Yujuan,et al."Composition-dependent membrane disruption by the proapoptotic protein PB1F2 from HK97 influenza A virus".FEBS LETTERS 592.15(2018):2572-2581.

入库方式： OAI收割

来源：合肥物质科学研究院

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