Non-reducible disulfide bond replacement implies that disulfide exchange is not required for hepcidin-ferroportin interaction
文献类型：期刊论文
| 作者 | Huang, Dong-Liang5,6,7; Bai, Jing-Si8; Wu, Meng5; Wang, Xia8; Riedl, Bernd1; Pook, Elisabeth2; Alt, Carsten3,4; Erny, Marion3; Li, Yi-Ming8; Bierer, Donald1 |
| 刊名 | CHEMICAL COMMUNICATIONS
 |
| 出版日期 | 2019-03-07 |
| 卷号 | 55期号:19页码:2821-2824 |
| ISSN号 | 1359-7345 |
| DOI | 10.1039/c9cc00328b |
| 通讯作者 | Shi, Jing(shijing@ustc.edu.cn) ; Fang, Ge-Min(fanggm@ahu.edu.cn) |
| 英文摘要 | Previous studies have led to opposing hypotheses about the requirement of intermolecular disulfide exchange in the binding of the iron regulatory peptide hepcidin to its receptor ferroportin. To clarify this issue, we used the diaminodiacid approach to replace the disulfide bonds in hepcidin with non-reducible thioether bonds. Our results implied that disulfide exchange is not required for the interaction between hepcidin and ferroportin. This theory is further supported by our development of biologically active minihepcidins that do not show activity dependence on cysteine. |
| WOS关键词 | CHEMICAL-SYNTHESIS ; BINDING-SITE ; MINIHEPCIDINS ; ANALOGS ; MECHANISM ; PEPTIDES ; PROTEINS ; BRIDGES |
| 资助项目 | National Key R&D Program of China[2017YFA0505400] ; NSFC[21572214] ; NSFC[21807001] ; NSFC[91753205] |
| WOS研究方向 | Chemistry |
| 语种 | 英语 |
| 出版者 | ROYAL SOC CHEMISTRY |
| WOS记录号 | WOS:000460683700018 |
| 资助机构 | National Key R&D Program of China ; National Key R&D Program of China ; National Key R&D Program of China ; National Key R&D Program of China ; NSFC ; NSFC ; NSFC ; NSFC ; National Key R&D Program of China ; National Key R&D Program of China ; National Key R&D Program of China ; National Key R&D Program of China ; NSFC ; NSFC ; NSFC ; NSFC |
| 源URL | [http://ir.hfcas.ac.cn:8080/handle/334002/42375]  |
| 专题 | 合肥物质科学研究院_中科院强磁场科学中心 |
| 通讯作者 | Shi, Jing; Fang, Ge-Min |
| 作者单位 | 1.Bayer AG, Dept Med Chem, Aprather Weg 18A, D-42096 Wuppertal, Germany 2.Bayer AG, Lead Discovery Wuppertal, Wuppertal, Germany 3.Bayer AG, Hematol Res, Wuppertal, Germany 4.Global Blood Therapeut, San Francisco, CA USA 5.Anhui Univ, Inst Hlth Sci & Technol, Inst Phys Sci & Informat Technol, Sch Life Sci, Hefei 230601, Anhui, Peoples R China 6.Chinese Acad Sci, High Field Magnet Lab, Hefei 230031, Peoples R China 7.Univ Sci & Technol China, Dept Chem, Hefei 230026, Peoples R China 8.Hefei Univ Technol, Sch Food & Biol Engn, Hefei 230009, Anhui, Peoples R China |
| 推荐引用方式 GB/T 7714 | Huang, Dong-Liang,Bai, Jing-Si,Wu, Meng,et al. Non-reducible disulfide bond replacement implies that disulfide exchange is not required for hepcidin-ferroportin interaction[J]. CHEMICAL COMMUNICATIONS,2019,55(19):2821-2824. |
| APA | Huang, Dong-Liang.,Bai, Jing-Si.,Wu, Meng.,Wang, Xia.,Riedl, Bernd.,...&Fang, Ge-Min.(2019).Non-reducible disulfide bond replacement implies that disulfide exchange is not required for hepcidin-ferroportin interaction.CHEMICAL COMMUNICATIONS,55(19),2821-2824. |
| MLA | Huang, Dong-Liang,et al."Non-reducible disulfide bond replacement implies that disulfide exchange is not required for hepcidin-ferroportin interaction".CHEMICAL COMMUNICATIONS 55.19(2019):2821-2824. |
入库方式： OAI收割
来源：合肥物质科学研究院
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