Biocatalytic upgrading of levulinic acid to methyl levulinate in green solvents
文献类型：期刊论文
| 作者 | Di, Xiaohui1,2,3,4; Zhang, Yu2,3,4 ; Fu, Junying2,3,4; Yu, Qiang2,3,4; Wang, Zhongming2,3,4; Yuan, Zhenhong2,3,4
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| 刊名 | PROCESS BIOCHEMISTRY
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| 出版日期 | 2019-06-01 |
| 卷号 | 81页码:33-38 |
| 关键词 | Enzyme-Catalyzed esterification Levulinic acid Immobilized lipases Double-Peak relationship Ionic liquid |
| ISSN号 | 1359-5113 |
| DOI | 10.1016/j.procbio.2019.03.024 |
| 通讯作者 | Zhang, Yu(zhangyu@ms.giec.ac.cn) ; Yu, Qiang(yuqiang@ms.giec.ac.cn) |
| 英文摘要 | High value-added utilization of biomass-based platform chemicals has attracted increasing attention in recent years. The present study addresses the upgrading of levulinic acid (LA), an important biomass-based platform chemical, to methyl levulinate via a green and efficient enzymatic approach. Various lipases were assessed, with Novozym((R)) 435 displaying the best results for the esterification of LA. Subsequently, the effect of reaction medium on Novozym((R)) 435 catalyzed esterification was also studied. Compared with other reaction media, 1-butyl-3-methylimidazolium hexafluorophosphate ([bmim] [PF6]) showed the greatest enhancement in yield by suppressing hydrolysis activity. The catalysts reusability was also improved by protection from [bmim][PF6] with 43.2% activity remained after 5 cycles, compared to that of 19.1% in 2-Me THF. Reaction temperature exerted an unusual double-peak relationship over methyl levulinate yield because Novozym((R)) 435 can simultaneously catalyze the esterification of LA and hydrolysis of methyl levulinate, each of which has a different optimal reaction temperature: ca. 30 degrees C and ca. 40 degrees C, respectively. When the molar ratio of LA/methanol, and the volume ratio of methanol/[bmim] [PF6] were 1:5 and 1:3, respectively, methyl levulinate was obtained in 93% yield at 30 degrees C after 24 h with 10 mg/mL catalytic loading. |
| WOS关键词 | IONIC LIQUIDS ; ENZYME CATALYSIS ; CONVERSION ; STABILITY ; BIODIESEL ; LIPASES ; ETHER ; HMF |
| 资助项目 | National Natural Science Foundation of China[21506215] ; National Natural Science Foundation of China[51876206] ; Municipal Science and Technology Project of Guangzhou (China)[201804010081] |
| WOS研究方向 | Biochemistry & Molecular Biology ; Biotechnology & Applied Microbiology ; Engineering |
| 语种 | 英语 |
| WOS记录号 | WOS:000469158700005 |
| 出版者 | ELSEVIER SCI LTD |
| 资助机构 | National Natural Science Foundation of China ; Municipal Science and Technology Project of Guangzhou (China) |
| 源URL | [http://ir.giec.ac.cn/handle/344007/25127]  |
| 专题 | 中国科学院广州能源研究所 |
| 通讯作者 | Zhang, Yu; Yu, Qiang |
| 作者单位 | 1.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 2.Chinese Acad Sci, Guangzhou Inst Energy Convers, Guangzhou 510640, Guangdong, Peoples R China 3.CAS Key Lab Renewable Energy, Guangzhou 510640, Guangdong, Peoples R China 4.Guangdong Prov Key Lab New & Renewable Energy Res, Guangzhou 510640, Guangdong, Peoples R China |
| 推荐引用方式 GB/T 7714 | Di, Xiaohui,Zhang, Yu,Fu, Junying,et al. Biocatalytic upgrading of levulinic acid to methyl levulinate in green solvents[J]. PROCESS BIOCHEMISTRY,2019,81:33-38. |
| APA | Di, Xiaohui,Zhang, Yu,Fu, Junying,Yu, Qiang,Wang, Zhongming,&Yuan, Zhenhong.(2019).Biocatalytic upgrading of levulinic acid to methyl levulinate in green solvents.PROCESS BIOCHEMISTRY,81,33-38. |
| MLA | Di, Xiaohui,et al."Biocatalytic upgrading of levulinic acid to methyl levulinate in green solvents".PROCESS BIOCHEMISTRY 81(2019):33-38. |
入库方式： OAI收割
来源：广州能源研究所
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