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The evolutionary history of Neanderthal and Denisovan Y chromosomes

文献类型：期刊论文

作者Petr, Martin2; Hajdinjak, Mateja2,3; Fu, Qiaomei4,5,6; Essel, Elena2; Rougier, Helene7; Crevecoeur, Isabelle1; Semal, Patrick8; Golovanova, Liubov, V9; Doronichev, Vladimir B.9; Lalueza-Fox, Carles10
刊名SCIENCE
出版日期2020-09-25
卷号369期号:6511页码:1653-+
ISSN号0036-8075
DOI10.1126/science.abb6460
通讯作者Petr, Martin(mp@bodkan.net) ; Kelso, Janet(kelso@eva.mpg.de)
英文摘要Ancient DNA has provided new insights into many aspects of human history. However, we lack comprehensive studies of the Y chromosomes of Denisovans and Neanderthals because the majority of specimens that have been sequenced to sufficient coverage are female. Sequencing Y chromosomes from two Denisovans and three Neanderthals shows that the Y chromosomes of Denisovans split around 700 thousand years ago from a lineage shared by Neanderthals and modern human Y chromosomes, which diverged from each other around 370 thousand years ago. The phylogenetic relationships of archaic and modern human Y chromosomes differ from the population relationships inferred from the autosomal genomes and mirror mitochondrial DNA phylogenies, indicating replacement of both the mitochondrial and Y chromosomal gene pools in late Neanderthals. This replacement is plausible if the low effective population size of Neanderthals resulted in an increased genetic load in Neanderthals relative to modern humans.
WOS关键词GENOME SEQUENCE ; DNA-SEQUENCES ; ANCIENT BONES ; GENE FLOW ; MITOCHONDRIAL ; CAVE ; PATTERNS ; PHYLOGENY
资助项目Chinese Academy of Sciences[XDB26000000] ; National Natural Science Foundation of China[91731303] ; National Natural Science Foundation of China[41925009] ; National Natural Science Foundation of China[41630102] ; Spanish government (MICINN/FEDER)[CGL2016-75109-P] ; Belgian Science Policy Office (BELSPO)[MO/36/0112] ; Russian Foundation for Basic Research[RFBR 17-29-04206] ; Max Planck Society ; European Research Council[694707]
WOS研究方向Science & Technology - Other Topics
语种英语
WOS记录号WOS:000574653300040
出版者AMER ASSOC ADVANCEMENT SCIENCE
资助机构Chinese Academy of Sciences ; National Natural Science Foundation of China ; Spanish government (MICINN/FEDER) ; Belgian Science Policy Office (BELSPO) ; Russian Foundation for Basic Research ; Max Planck Society ; European Research Council
源URL[http://119.78.100.205/handle/311034/18113]  
专题中国科学院古脊椎动物与古人类研究所
通讯作者Petr, Martin; Kelso, Janet
作者单位1.Univ Bordeaux, CNRS, UMR PACEA 5199, F-33615 Pessac, France
2.Max Planck Inst Evolutionary Anthropol, Dept Evolutionary Genet, D-04103 Leipzig, Germany
3.Francis Crick Inst, London NW1 1AT, England
4.Chinese Acad Sci, CAS, IVPP, Key Lab Vertebrate Evolut & Human Origins, Beijing 100044, Peoples R China
5.CAS Ctr Excellence Life & Paleoenvironm, Beijing 100044, Peoples R China
6.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
7.Calif State Univ Northridge, Dept Anthropol, Northridge, CA 91330 USA
8.Royal Belgian Inst Nat Sci, B-1000 Brussels, Belgium
9.ANO Lab Prehist 14 Linia 3 11, St Petersburg 199034, Russia
10.Univ Pompeu Fabra, Inst Evolutionary Biol, CSIC, Barcelona 08003, Spain
推荐引用方式
GB/T 7714		 Petr, Martin,Hajdinjak, Mateja,Fu, Qiaomei,et al. The evolutionary history of Neanderthal and Denisovan Y chromosomes[J]. SCIENCE,2020,369(6511):1653-+.
APA Petr, Martin.,Hajdinjak, Mateja.,Fu, Qiaomei.,Essel, Elena.,Rougier, Helene.,...&Kelso, Janet.(2020).The evolutionary history of Neanderthal and Denisovan Y chromosomes.SCIENCE,369(6511),1653-+.
MLA Petr, Martin,et al."The evolutionary history of Neanderthal and Denisovan Y chromosomes".SCIENCE 369.6511(2020):1653-+.

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来源：古脊椎动物与古人类研究所

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