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Betel quid-associated cancer: Prevention strategies and targeted treatment

文献类型：期刊论文

作者Ko, Albert Min-Shan4; Lee, Chien-Hung2,3; Ko, Ying-Chin1,5
刊名CANCER LETTERS
出版日期2020-05-01
卷号477期号:0页码:60-69
关键词Detoxification Carcinogenesis Chemoprevention Arecoline N-Oxide Reactive oxygen species
ISSN号0304-3835
DOI10.1016/j.canlet.2020.02.030
英文摘要Betel quid (BQ) and areca nut use are at risk of cancer. This review includes the latest evidence of carcinogenesis caused by BQ exposure, suggests possible prevention strategies. We conducted a systematic literature search in the PubMed and Web of Science databases to identify relevant articles published in the past 10 years according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses criteria. Arecoline N-oxide, a metabolite of areca nut, is likely an initiator in carcinogenesis and is detoxified by N-acetylcysteine. Oral potentially malignant disorder and reactive oxygen species involved in carcinogenesis pathways may be treatable using antioxidants. Screening programs conducted by trained physicians are useful for identifying patients with early stages of oral cancer in high-risk groups. Anti-inflammatory medications may be used as chemopreventive agents in the disease-free stage after surgery. The association between survival and tumor somatic mutations in patients who chew BQ should be addressed in cancer studies. Current evidence on the natural course from BQ exposure to cancer occurrence and development provides information for developing primary, secondary, and tertiary prevention strategies against BQ-associated cancer at clinical or translational levels.
WOS关键词SQUAMOUS-CELL CARCINOMA ; ORAL SUBMUCOUS FIBROSIS ; POTENTIALLY MALIGNANT DISORDERS ; ARECOLINE N-OXIDE ; ARECA-CATECHU NUT ; ALCOHOL-CONSUMPTION ; TOBACCO SMOKING ; BUCCAL MUCOSA ; RISK ; SALIVA
资助项目Ministry of Science and Technology[MOST 106-2314-B-039-016-MY3] ; China Medical University Hospital[DMR 109-250]
WOS研究方向Oncology
语种英语
WOS记录号WOS:000525867900007
出版者ELSEVIER IRELAND LTD
源URL[http://119.78.100.205/handle/311034/17321]  
专题古脊椎动物与古人类研究所_图书馆1
通讯作者Ko, Ying-Chin
作者单位1.Natl Taiwan Univ, Coll Med, Grad Inst Toxicol, Taipei, Taiwan
2.Kaohsiung Med Univ, Dept Publ Hlth & Res, Ctr Environm Med, Kaohsiung, Taiwan
3.Kaohsiung Med Univ Hosp, Dept Med Res, Kaohsiung, Taiwan
4.Chinese Acad Sci, Key Lab Vertebrate Evolut & Human Origins, Inst Vertebrate Paleontol & Paleoanthropol, Beijing, Peoples R China
5.China Med Univ, China Med Univ Hosp, Environm Omics Dis Res Ctr, Taichung, Taiwan
推荐引用方式
GB/T 7714		 Ko, Albert Min-Shan,Lee, Chien-Hung,Ko, Ying-Chin. Betel quid-associated cancer: Prevention strategies and targeted treatment[J]. CANCER LETTERS,2020,477(0):60-69.
APA Ko, Albert Min-Shan,Lee, Chien-Hung,&Ko, Ying-Chin.(2020).Betel quid-associated cancer: Prevention strategies and targeted treatment.CANCER LETTERS,477(0),60-69.
MLA Ko, Albert Min-Shan,et al."Betel quid-associated cancer: Prevention strategies and targeted treatment".CANCER LETTERS 477.0(2020):60-69.

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来源：古脊椎动物与古人类研究所

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