Effect of antidepressants for cessation therapy in betel-quid use disorder: a randomised, double-blind, placebo-controlled trial
文献类型：期刊论文
| 作者 | Hung, Chung-Chieh2,3; Lee, Chien-Hung4,5,6; Ko, Albert Min-Shan7; Lane, Hsien-Yuan1,2,3; Lee, Chi-Pin8; Ko, Ying-Chin8 |
| 刊名 | EPIDEMIOLOGY AND PSYCHIATRIC SCIENCES
 |
| 出版日期 | 2020 |
| 卷号 | 29页码:10 |
| 关键词 | Clinical drug studies common mental disorders epidemiology psychoactive substance use disorder randomised controlled trials |
| ISSN号 | 2045-7960 |
| DOI | 10.1017/S2045796020000384 |
| 通讯作者 | Ko, Ying-Chin(ycko0406@gmail.com) |
| 英文摘要 | Aims More than one-half of betel-quid (BQ) chewers have betel-quid use disorder (BUD). However, no medication has been approved. We performed a randomised clinical trial to test the efficacy of taking escitalopram and moclobemide antidepressants on betel-quid chewing cessation (BQ-CC) treatment. Methods We enrolled 111 eligible male BUD patients. They were double-blinded, placebo-controlled and randomised into three treatment groups: escitalopram 10 mg/tab daily, moclobemide 150 mg/tab daily and placebo. Patients were followed-up every 2 weeks and the length of the trial was 8 weeks. The primary outcome was BQ-CC, defined as BUD patients who continuously stopped BQ use for > 6 weeks. The secondary outcomes were the frequency and amount of BQ intake, and two psychological rating scales. Several clinical adverse effects were measured during the 8-week treatment. Results Intention-to-treat analysis shows that after 8 weeks, two (5.4%), 13 (34.2%) and 12 (33.3%) of BUD patients continuously quit BQ chewing for > 6 weeks among placebo, escitalopram, moclobemide groups, respectively. The adjusted proportion ratio of BQ-CC was 6.3 (95% CI 1.5-26.1) and 6.8 (95% CI 1.6-28.0) for BUD patients who used escitalopram and moclobemide, respectively, as compared with those who used placebo. BUD patients with escitalopram and moclobemide treatments both exhibited a significantly lower frequency and amount of BQ intake at the 8th week than those with placebo. Conclusions Prescribing a fixed dose of moclobemide and escitalopram to BUD patients over 8 weeks demonstrated treatment benefits to BQ-CC. Given a relatively small sample, this study provides preliminary evidence and requires replication in larger trials. |
| WOS关键词 | OBSESSIVE-COMPULSIVE SCALE ; PROTEIN MODIFICATION ; CHINESE VERSION ; ARECA NUT ; DEPENDENCE ; SUBSTRATE ; ESCITALOPRAM ; INVENTORY ; SEVERITY ; MEMORY |
| 资助项目 | Taiwan Ministry of Health and Welfare Clinical Trial Center[MOHW109-TDU-B212-114004] ; China Medical University Hospital[DMR-106-098] ; China Medical University Hospital[DMR-108-094] |
| WOS研究方向 | Psychiatry |
| 语种 | 英语 |
| WOS记录号 | WOS:000530304700001 |
| 出版者 | CAMBRIDGE UNIV PRESS |
| 资助机构 | Taiwan Ministry of Health and Welfare Clinical Trial Center ; China Medical University Hospital |
| 源URL | [http://119.78.100.205/handle/311034/17417]  |
| 专题 | 古脊椎动物与古人类研究所_图书馆1 |
| 通讯作者 | Ko, Ying-Chin |
| 作者单位 | 1.Asia Univ, Coll Med & Hlth Sci, Dept Psychol, Taichung, Taiwan 2.China Med Univ, Grad Inst Clin Med Sci, Taichung, Taiwan 3.China Med Univ Hosp, Dept Psychiat, Taichung, Taiwan 4.Kaohsiung Med Univ, Dept Publ Hlth, Kaohsiung, Taiwan 5.Kaohsiung Med Univ, Res Ctr Environm Med, Kaohsiung, Taiwan 6.Kaohsiung Med Univ Hosp, Dept Med Res, Kaohsiung, Taiwan 7.Chinese Acad Sci, Inst Vertebrate Paleontol & Paleoanthropol, Key Lab Vertebrate Evolut & Human Origins, Beijing, Peoples R China 8.China Med Univ, China Med Univ Hosp, Environm Omics Dis Res Ctr, Taichung, Taiwan |
| 推荐引用方式 GB/T 7714 | Hung, Chung-Chieh,Lee, Chien-Hung,Ko, Albert Min-Shan,et al. Effect of antidepressants for cessation therapy in betel-quid use disorder: a randomised, double-blind, placebo-controlled trial[J]. EPIDEMIOLOGY AND PSYCHIATRIC SCIENCES,2020,29:10. |
| APA | Hung, Chung-Chieh,Lee, Chien-Hung,Ko, Albert Min-Shan,Lane, Hsien-Yuan,Lee, Chi-Pin,&Ko, Ying-Chin.(2020).Effect of antidepressants for cessation therapy in betel-quid use disorder: a randomised, double-blind, placebo-controlled trial.EPIDEMIOLOGY AND PSYCHIATRIC SCIENCES,29,10. |
| MLA | Hung, Chung-Chieh,et al."Effect of antidepressants for cessation therapy in betel-quid use disorder: a randomised, double-blind, placebo-controlled trial".EPIDEMIOLOGY AND PSYCHIATRIC SCIENCES 29(2020):10. |
入库方式： OAI收割
来源：古脊椎动物与古人类研究所
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