Evidence of proteins, chromosomes and chemical markers of DNA in exceptionally preserved dinosaur cartilage
文献类型：期刊论文
| 作者 | Bailleul, Alida M.2,4; Zheng, Wenxia3; Horner, John R.5; Hall, Brian K.6; Holliday, Casey M.7; Schweitzer, Mary H.1,3,8 |
| 刊名 | NATIONAL SCIENCE REVIEW
 |
| 出版日期 | 2020-04-01 |
| 卷号 | 7期号:4页码:815-822 |
| 关键词 | cartilage dinosaur nuclei chromosomes collagen II DNA markers |
| ISSN号 | 2095-5138 |
| DOI | 10.1093/nsr/nwz206 |
| 英文摘要 | A histological ground-section from a duck-billed dinosaur nestling (Hypacrosaurus stebingeri) revealed microstructures morphologically consistent with nuclei and chromosomes in cells within calcified cartilage. We hypothesized that this exceptional cellular preservation extended to the molecular level and had molecular features in common with extant avian cartilage. Histochemical and immunological evidence supports in situ preservation of extracellular matrix components found in extant cartilage, including glycosaminoglycans and collagen type II. Furthermore, isolated Hypacrosaurus chondrocytes react positively with two DNA intercalating stains. Specific DNA staining is only observed inside the isolated cells, suggesting endogenous nuclear material survived fossilization. Our data support the hypothesis that calcified cartilage is preserved at the molecular level in this Mesozoic material, and suggest that remnants of once-living chondrocytes, including their DNA, may preserve for millions of years. |
| WOS关键词 | SOFT-TISSUE ; CELL-DEATH ; GROWTH ; CHONDROCYTES ; BONE ; APOPTOSIS ; SEQUENCE ; VESSELS ; GENOME |
| 资助项目 | National Science Foundation INSPIRE grant (Division of Earth Sciences)[EAR-1344198] ; American Association of Anatomists Short-Term Visiting Scholarship ; Chinese Academy of Sciences-President's International Fellowship Initiative (CAS-PIFI) ; NSF-IOS grant (Division of Integrative Organismal Systems)[1457319] |
| WOS研究方向 | Science & Technology - Other Topics |
| 语种 | 英语 |
| WOS记录号 | WOS:000537456300011 |
| 出版者 | OXFORD UNIV PRESS |
| 源URL | [http://119.78.100.205/handle/311034/17533]  |
| 专题 | 古脊椎动物与古人类研究所_图书馆1 |
| 通讯作者 | Bailleul, Alida M. |
| 作者单位 | 1.Lund Univ, Dept Geol, S-22362 Lund, Sweden 2.CAS Ctr Excellence Life & Paleoenvironm, Beijing 100044, Peoples R China 3.North Carolina State Univ, Dept Biol Sci, Raleigh, NC 27695 USA 4.Chinese Acad Sci, Key Lab Vertebrate Evolut & Human Origins, Inst Vertebrate Paleontol & Paleoanthropol, Beijing 100044, Peoples R China 5.Chapman Univ, Honors Program, Orange, CA 92866 USA 6.Dalhousie Univ, Dept Biol, Halifax, NS B3H 4R2, Canada 7.Univ Missouri, Dept Pathol & Anat Sci, Columbia, MO 65211 USA 8.North Uarolina Museum Nat Sci, Raleigh, NC 27601 USA |
| 推荐引用方式 GB/T 7714 | Bailleul, Alida M.,Zheng, Wenxia,Horner, John R.,et al. Evidence of proteins, chromosomes and chemical markers of DNA in exceptionally preserved dinosaur cartilage[J]. NATIONAL SCIENCE REVIEW,2020,7(4):815-822. |
| APA | Bailleul, Alida M.,Zheng, Wenxia,Horner, John R.,Hall, Brian K.,Holliday, Casey M.,&Schweitzer, Mary H..(2020).Evidence of proteins, chromosomes and chemical markers of DNA in exceptionally preserved dinosaur cartilage.NATIONAL SCIENCE REVIEW,7(4),815-822. |
| MLA | Bailleul, Alida M.,et al."Evidence of proteins, chromosomes and chemical markers of DNA in exceptionally preserved dinosaur cartilage".NATIONAL SCIENCE REVIEW 7.4(2020):815-822. |
入库方式： OAI收割
来源：古脊椎动物与古人类研究所
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