Setosphapyrone C and D accelerate macrophages cholesterol efflux by promoting LXR alpha/ABCA1 pathway
文献类型：期刊论文
| 作者 | Li, Ting3; Yin, Jiayu3; Ji, Yubin; Lin, Ping3; Li, Yanjie3; Yang, Zixun3; Hu, Shumei3; Wang, Jin3; Zhang, Baihui3; Koshti, Saloni1 |
| 刊名 | ARCHIVES OF PHARMACAL RESEARCH
 |
| 关键词 | LXR antagonist Reverse cholesterol transport Hyperlipidemia ATP-binding cassette transporter |
| ISSN号 | 0253-6269 |
| DOI | 10.1007/s12272-020-01255-w |
| 英文摘要 | LXR alpha agonists have attracted significant attention due to their potential biological activities on promoting cholesterol efflux. This study was designed to investigate whether setosphapyrone C and D have potential lipid-lowering capacity and the underlying mechanisms in vitro. Our data showed that setosphapyrone C and D had weak cytotoxicity compared to the liver X receptor alpha (LXR alpha) agonist T0901317. In RAW 264.7 macrophages, setosphapyrone C and D significantly enhanced [H-3]-cholesterol efflux by similar to 21.3% and 32.4%, respectively; furthermore, setosphapyrone C and D enhanced the protein levels of ATP-binding cassette transporter (ABC) A1 and LXR alpha by 58% and 69%, and 60% and 70% (8 mu M), respectively; however, they had no effect on the protein levels of ABCG1 and scavenger receptor B type 1; additionally, they had minor effect on the mRNA expression of lipogenic genes. Of note, setosphapyrone C and D significantly enhanced LXR alpha/ABCA1pathway in mice primary macrophages. In BRL cells, setosphapyrone C and D significantly improved the protein levels of ABCA1 and ABCG1; setosphapyrone D significantly enhanced the protein expression of low-density lipoprotein. Collectively, setosphapyrone C and D with weak cytotoxicity exhibited effective lipid-lowering effect via enhancing LXR alpha/ABC pathways. Setosphapyrones possess potential application for the treatment of hyperlipidemic diseases. |
| 资助机构 | Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81770463, 31300639]; Shandong Provincial Natural Science FundNatural Science Foundation of Shandong Province [ZR2013HQ014]; Medicine & Health Scientific Technology Development Program of Shandong Province [2018WS064]; Study Abroad Fund of Weifang Medical University ; Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81770463, 31300639]; Shandong Provincial Natural Science FundNatural Science Foundation of Shandong Province [ZR2013HQ014]; Medicine & Health Scientific Technology Development Program of Shandong Province [2018WS064]; Study Abroad Fund of Weifang Medical University |
| 源URL | [http://ir.scsio.ac.cn/handle/344004/18372]  |
| 专题 | 南海海洋研究所_中科院海洋生物资源可持续利用重点实验室 |
| 作者单位 | 1.Weifang Med Univ, Innovat Drug Res Ctr, Sch Pharm, Inst Lipid Metab & Atherosclerosis, Weifang 261053, Peoples R China 2.Chinese Acad Sci, Guangdong Key Lab Marine Mat Med, South China Sea Inst Oceanol, CAS Key Lab Trop Marine Bioresources & Ecol,RNAM, Guangzhou 510220, Peoples R China 3.Harbin Univ Commerce, Coll Pharm Engn Res Ctr Med, Harbin 150076, Peoples R China 4.Univ Alberta, Dept Physiol, Edmonton, AB T6G 2R3, Canada |
| 推荐引用方式 GB/T 7714 | Li, Ting,Yin, Jiayu,Ji, Yubin,et al. Setosphapyrone C and D accelerate macrophages cholesterol efflux by promoting LXR alpha/ABCA1 pathway[J]. ARCHIVES OF PHARMACAL RESEARCH. |
| APA | Li, Ting.,Yin, Jiayu.,Ji, Yubin.,Lin, Ping.,Li, Yanjie.,...&Guo, Shoudong. |
| MLA | Li, Ting,et al."Setosphapyrone C and D accelerate macrophages cholesterol efflux by promoting LXR alpha/ABCA1 pathway".ARCHIVES OF PHARMACAL RESEARCH |
入库方式： OAI收割
来源：南海海洋研究所
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