Targeted isolation of new polycyclic tetramate macrolactams from the deepsea-derived Streptomyces somaliensis SCSIO ZH66
文献类型：期刊论文
| 作者 | Hou, Lukuan; Liu, Zengzhi; Yu, Dongqi; Li, Huayue1; Ju, Jianhua3; Li, Wenli1 |
| 刊名 | BIOORGANIC CHEMISTRY
 |
| 出版日期 | 2020 |
| 卷号 | 101页码:103954 |
| 关键词 | Polycyclic tetramate macrolactam Deepsea-derived Streptomyces Gene inactivation Antifungal Cytotoxicity |
| ISSN号 | 0045-2068 |
| DOI | 10.1016/j.bioorg.2020.103954 |
| 英文摘要 | With a combined strategy of bioinformatics analysis, gene manipulation coupled with variation of growth conditions, the targeted activation of polycyclic tetramate macrolactams (PTMs) in the deepsea-derived Streptomyces somaliensis SCSIO ZH66 was conducted, which afforded a new (1) PTM, named somamycin A, along with three enol-type tetramic acid tautomers (2-4, somamycins B-D) of 10-epi-hydroxymaltophilin, 10-epi- maltophilin and 10-epi-HSAF, respectively. The structures of compounds 1-4 were elucidated by extensive spectroscopic analyses together with ECD calculations. Compound 1 exhibited notable growth inhibition against plant pathogenic fungi Fusarium oxysporum MHKW and Alternaria brassicae BCHB with the MIC values of 1.6 and 3.1 mu g/mL, respectively, which were more potent than those of the positive control nystatin; and compounds 3 and 4 displayed moderate antifungal activities. Moreover, compounds 1-4 exhibited moderate cytotoxicity against the human cancer cell lines of HCT116 and K562. |
| 资助机构 | National Natural Science Foundation of China NSFC-Shandong Joint Foundation [U1706206]; National Key R&D Program of China [2019YFC0312501]; National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [31570032, 81991525, 21502180, 31711530219, 41506157]; Science and Technology Project of Qingdao [17-3-3-44-nsh] ; National Natural Science Foundation of China NSFC-Shandong Joint Foundation [U1706206]; National Key R&D Program of China [2019YFC0312501]; National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [31570032, 81991525, 21502180, 31711530219, 41506157]; Science and Technology Project of Qingdao [17-3-3-44-nsh] |
| 源URL | [http://ir.scsio.ac.cn/handle/344004/18373]  |
| 专题 | 南海海洋研究所_中科院海洋生物资源可持续利用重点实验室 |
| 作者单位 | 1.Ocean Univ China, Sch Med & Pharm, Key Lab Marine Drugs, Minist Educ, Qingdao 266003, Peoples R China 2.Chinese Acad Sci, RNAM Ctr Marine Microbiol, South China Sea Inst Oceanol,Guangdong Key Lab Ma, CAS Key Lab Marine Bioresources Sustainable Utili, Guangzhou 510301, Peoples R China 3.Qingdao Natl Lab Marine Sci & Technol, Lab Marine Drugs & Bioprod, Qingdao 266237, Peoples R China |
| 推荐引用方式 GB/T 7714 | Hou, Lukuan,Liu, Zengzhi,Yu, Dongqi,et al. Targeted isolation of new polycyclic tetramate macrolactams from the deepsea-derived Streptomyces somaliensis SCSIO ZH66[J]. BIOORGANIC CHEMISTRY,2020,101:103954. |
| APA | Hou, Lukuan,Liu, Zengzhi,Yu, Dongqi,Li, Huayue,Ju, Jianhua,&Li, Wenli.(2020).Targeted isolation of new polycyclic tetramate macrolactams from the deepsea-derived Streptomyces somaliensis SCSIO ZH66.BIOORGANIC CHEMISTRY,101,103954. |
| MLA | Hou, Lukuan,et al."Targeted isolation of new polycyclic tetramate macrolactams from the deepsea-derived Streptomyces somaliensis SCSIO ZH66".BIOORGANIC CHEMISTRY 101(2020):103954. |
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来源：南海海洋研究所
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