Semi-synthesis and characterization of some new matrine derivatives as insecticidal agents
文献类型：期刊论文
| 作者 | Cheng, Xingan3; He, Huiqing; Wang, Wen-Xiong; Dong, Fangyun; Zhang, Hanhui; Ye, Jingmin; Tan, Chuncan; Wu, Yuehua; Lv, Xiaojing; Jiang, Xuhong |
| 刊名 | PEST MANAGEMENT SCIENCE
 |
| 出版日期 | 2020 |
| 卷号 | 76期号:8页码:2711 |
| ISSN号 | 1526-498X |
| 关键词 | matrine derivative structural modification structural characterization insecticidal activity |
| DOI | 10.1002/ps.5817 |
| 英文摘要 | BACKGROUND Matrine is an important traditional plant-derived insecticide with broad-spectrum activity. However, due to its moderate activity, matrine is mainly applied in combination with other pesticides. In order to discover new potential natural-product-based crop protection agents, a series of matrine derivatives characterized by cyclohexylamine group were synthesized to screen their insecticidal activity against seven typically agricultural pests. RESULTS The structural configurations of compounds were characterized by IR,H-1 NMR,C-13 NMR, MS and XRD, with the pure yields of 42%, 65% and 71%, respectively. Although all compounds showed poor insecticidal activity against five lepidoptera pests, the compounds 2 and 4 displayed remarkable insecticidal activities againstLipaphis erysimiandMulberry Root-Knot Nematodewith a concentration-dependent manner within 0.5~1.5 mg/ mL. Compared with matrine (60%), compounds 2 and 4 exhibited potent insecticidal activities againstL. erysimi, with a corrected mortality of 83.3% and 89.7%, respectively. They also showed excellent control effects onMulberry Root-Knot Nematode, with corrected mortality as high as 88% and 80%, respectively. CONCLUSION All four synthesized matrine derivatives showed poor insecticidal activity against five lepidoptera pests, but the compounds 2 and 4 exhibited much stronger insecticidal activities againstL. erysimiandMulberry Root-Knot Nematodethan matrine. Combined with the structural characteristics of compounds 1~4, we conclude that 4-methylcyclohexylamine, not the carbon disulfide group or cyclohexylamine group alone, mainly contributed to the improvement of insecticidal activities of matrine derivatives against these two agricultural pests. This work provides a direction and foundation for structural optimization of the matrine pesticides in the future. (c) 2020 Society of Chemical Industry |
| 资助机构 | National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [21406274, 31970047L]; National Undergraduate Training Program for Innovation and Entrepreneurship [201811347001]; Guangdong Quality Engineering Project and Teaching Team Project [KA190573931, KA190574204]; Guangdong Special Commissioners of Science and Technology [KA1810303] ; National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [21406274, 31970047L]; National Undergraduate Training Program for Innovation and Entrepreneurship [201811347001]; Guangdong Quality Engineering Project and Teaching Team Project [KA190573931, KA190574204]; Guangdong Special Commissioners of Science and Technology [KA1810303] |
| 源URL | [http://ir.scsio.ac.cn/handle/344004/18375]  |
| 专题 | 南海海洋研究所_中科院海洋生物资源可持续利用重点实验室 |
| 作者单位 | 1.Hong Kong Univ Sci & Technol HKUST, Dept Ocean Sci, Kowloon, Clear Water Bay, Hong Kong, Peoples R China 2.City Univ Hong Kong, Sch Energy & Environm, Kowloon, Hong Kong, Peoples R China 3.City Univ Hong Kong, State Key Lab Marine Pollut, Kowloon, Hong Kong, Peoples R China 4.Zhongkai Univ Agr & Engn, Coll Chem & Chem Engn, Inst Nat Prod Chem, Guangzhou 510225, Guangdong, Peoples R China 5.Chinese Acad Sci, South China Sea Inst Oceanol, CAS Key Lab Trop Marine Bioresources & Ecol, Guangdong Key Lab Marine Mat Med, Guangzhou 510301, Peoples R China |
| 推荐引用方式 GB/T 7714 | Cheng, Xingan,He, Huiqing,Wang, Wen-Xiong,et al. Semi-synthesis and characterization of some new matrine derivatives as insecticidal agents[J]. PEST MANAGEMENT SCIENCE,2020,76(8):2711, 2719. |
| APA | Cheng, Xingan.,He, Huiqing.,Wang, Wen-Xiong.,Dong, Fangyun.,Zhang, Hanhui.,...&Qin, Xiangjing.(2020).Semi-synthesis and characterization of some new matrine derivatives as insecticidal agents.PEST MANAGEMENT SCIENCE,76(8),2711. |
| MLA | Cheng, Xingan,et al."Semi-synthesis and characterization of some new matrine derivatives as insecticidal agents".PEST MANAGEMENT SCIENCE 76.8(2020):2711. |
入库方式： OAI收割
来源：南海海洋研究所
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