Chemical Diversity of Metabolites and Antibacterial Potential of Actinomycetes Associated with Marine Invertebrates from Intertidal Regions of Daya Bay and Nansha Islands
文献类型：期刊论文
| 作者 | Kumar, P. S.; Ling, C. Y.; Zhou, Z. B.; Dong, Y. L.; Sun, C. L.; Song, Y. X.; Wong, N. K.; Ju, J. H. |
| 刊名 | MICROBIOLOGY
 |
| 出版日期 | 2020 |
| 卷号 | 89期号:4页码:483 |
| 关键词 | marine invertebrates secondary metabolites chemical fingerprinting antibacterial activity |
| ISSN号 | 0026-2617 |
| DOI | 10.1134/S0026261720040062 |
| 英文摘要 | Marine actinobacteria particularly from marine environments are believed to be inexhaustible sources of biologically active molecules for biomedical and industrial applications. We isolated 126 strains of marine actinomycetes from marine invertebrates such as corals, sponges and gastropod molluscs from Daya Bay and Nansha Islands. The chemical diversity of the metabolites from the isolated strains was evaluated using HPLC-UV fingerprinting and their antibacterial activity was estimated. Preliminary chemical screening and antibacterial activity clearly illustrate that the marine invertebrates-associated actinomycetes are a rich source of novel biologically active compounds. Among the isolates, strain SCSIO-PTE-L054 was further investigated for its unique metabolic profile and antibacterial activity. The bioassay-guided isolation rendered a polycyclic tetramate macrolactam (PTM) as a major chemical constituent with potent antibacterial activity. Our results revealed that theStreptomycessp., strain SCSIO-L054 is a new source of PTMs which could pave a way to isolation of new series of PTMs with a broad spectrum of activity. In summary, the present investigation makes it possible to select marine actinomycetes from Daya Bay and Nansha Islands as new potential sources to produce potent compounds for a wide range of applications in future drug discovery. |
| 资助机构 | National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [41706169, U1501223, U1706206]; Chinese Academy of SciencesChinese Academy of Sciences [XDA13020302]; Natural Science Foundation of Guangdong ProvinceNational Natural Science Foundation of Guangdong Province [2016A030312014] ; National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [41706169, U1501223, U1706206]; Chinese Academy of SciencesChinese Academy of Sciences [XDA13020302]; Natural Science Foundation of Guangdong ProvinceNational Natural Science Foundation of Guangdong Province [2016A030312014] |
| 源URL | [http://ir.scsio.ac.cn/handle/344004/18386]  |
| 专题 | 南海海洋研究所_中科院海洋生物资源可持续利用重点实验室 |
| 作者单位 | 1.[Zhou, Z. B. 2.[Wong, N. K.] Southern Univ Sci & Technol, Hosp Affiliated 2, Shenzhen Peoples Hosp 3, State Key Discipline Infect Dis, Shenzhen, Peoples R China 3.Ju, J. H.] Univ Chinese Acad Sci, Beijing, Peoples R China 4.Ju, J. H.] Chinese Acad Sci, South China Sea Inst Oceanol, Guangdong Key Lab Marine Mat Med, CAS Key Lab Trop Marine Bioresources & Ecol, Guangzhou, Peoples R China 5.Song, Y. X. 6.Sun, C. L. 7.Dong, Y. L. 8.Zhou, Z. B. 9.Ling, C. Y. 10.[Kumar, P. S. |
| 推荐引用方式 GB/T 7714 | Kumar, P. S.,Ling, C. Y.,Zhou, Z. B.,et al. Chemical Diversity of Metabolites and Antibacterial Potential of Actinomycetes Associated with Marine Invertebrates from Intertidal Regions of Daya Bay and Nansha Islands[J]. MICROBIOLOGY,2020,89(4):483, 492. |
| APA | Kumar, P. S..,Ling, C. Y..,Zhou, Z. B..,Dong, Y. L..,Sun, C. L..,...&Ju, J. H..(2020).Chemical Diversity of Metabolites and Antibacterial Potential of Actinomycetes Associated with Marine Invertebrates from Intertidal Regions of Daya Bay and Nansha Islands.MICROBIOLOGY,89(4),483. |
| MLA | Kumar, P. S.,et al."Chemical Diversity of Metabolites and Antibacterial Potential of Actinomycetes Associated with Marine Invertebrates from Intertidal Regions of Daya Bay and Nansha Islands".MICROBIOLOGY 89.4(2020):483. |
入库方式： OAI收割
来源：南海海洋研究所
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