Characterization of Tailoring Methyltransferases Involved in K-41A Biosynthesis: Modulating Methylation to Improve K-41A Anti-infective Activity
文献类型：期刊论文
| 作者 | Chen, Jiang2; Gui, Chun2; Wei, Qiuyu3; Liu, Jie3; Ye, Li3; Tian, Xinpeng; Gu, Yu-Cheng; Li, Qinglian; Ju, Jianhua2 |
| 刊名 | ORGANIC LETTERS
 |
| 出版日期 | 2020 |
| 卷号 | 22期号:12页码:4627 |
| ISSN号 | 1523-7060 |
| DOI | 10.1021/acs.orglett.0c01347 |
| 英文摘要 | The biosynthetic gene cluster (BGC) for polyether antibiotic K-41A was identified from marine-derived Streptomyces sp. SCSIO 01680 and subjected to combinatorial biosynthetic study. Bioinformatics analyses, gene disruption, and metabolomics analyses afforded eight new derivatives and one known polyether, showcasing five region-specific methyltransferases Pak13, Pak1S, Pak20, Pak31, and Pak38 and their respective modification loci. Moreover, bioassays revealed that two disaccharide-bearing polyethers, K-41B and K-41Bm, display enhanced anti-HIV and potent antibacterial activities. |
| 资助机构 | National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [31970064, U1706206]; National Key Research and Development Program of China [2019YFC0312500, 2017YFD0201400]; Guangdong Local Innovation Team Program [2019BT02Y262]; Chinese Academy of SciencesChinese Academy of Sciences [XDA13020302]; Key Special Project for Introduced Talents Team of Southern Marine Science and Engineering Guangdong Laboratory (Guangzhou) [GML2019ZD0406]; Syngenta Ph.D. Fellowship Awarded ; National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [31970064, U1706206]; National Key Research and Development Program of China [2019YFC0312500, 2017YFD0201400]; Guangdong Local Innovation Team Program [2019BT02Y262]; Chinese Academy of SciencesChinese Academy of Sciences [XDA13020302]; Key Special Project for Introduced Talents Team of Southern Marine Science and Engineering Guangdong Laboratory (Guangzhou) [GML2019ZD0406]; Syngenta Ph.D. Fellowship Awarded |
| 源URL | [http://ir.scsio.ac.cn/handle/344004/18392]  |
| 专题 | 南海海洋研究所_中科院海洋生物资源可持续利用重点实验室 |
| 作者单位 | 1.Syngenta Jealotts Hill Int Res Ctr, Bracknell RG42 6EY, Berks, England 2.Chinese Acad Sci, South China Sea Inst Oceanol, RNAM Ctr Marine Microbiol, CAS Key Lab Trop Marine Bioresources & Ecol,Guang, Guangzhou 510301, Peoples R China 3.Univ Chinese Acad Sci, Coll Oceanol, Beijing 100049, Peoples R China 4.Guangxi Med Univ, Life Sci Inst, Guangxi Collaborat Innovat Ctr Biomed, Nanning 530021, Guangxi, Peoples R China |
| 推荐引用方式 GB/T 7714 | Chen, Jiang,Gui, Chun,Wei, Qiuyu,et al. Characterization of Tailoring Methyltransferases Involved in K-41A Biosynthesis: Modulating Methylation to Improve K-41A Anti-infective Activity[J]. ORGANIC LETTERS,2020,22(12):4627, 4632. |
| APA | Chen, Jiang.,Gui, Chun.,Wei, Qiuyu.,Liu, Jie.,Ye, Li.,...&Ju, Jianhua.(2020).Characterization of Tailoring Methyltransferases Involved in K-41A Biosynthesis: Modulating Methylation to Improve K-41A Anti-infective Activity.ORGANIC LETTERS,22(12),4627. |
| MLA | Chen, Jiang,et al."Characterization of Tailoring Methyltransferases Involved in K-41A Biosynthesis: Modulating Methylation to Improve K-41A Anti-infective Activity".ORGANIC LETTERS 22.12(2020):4627. |
入库方式： OAI收割
来源：南海海洋研究所
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