Physiologically Based Pharmacokinetic Model for the Biotransportation of Arsenic in Marine Medaka (Oryzias melastigma)
文献类型：期刊论文
| 作者 | Zhang, Wei2,3; Song, Dongdong3; Tan, Qiao-Guo; Wang, Wen-Xiong; Zhang, Li3 |
| 刊名 | ENVIRONMENTAL SCIENCE & TECHNOLOGY
 |
| 出版日期 | 2020 |
| 卷号 | 54期号:12页码:7485 |
| ISSN号 | 0013-936X |
| DOI | 10.1021/acs.est.0c01519 |
| 英文摘要 | The toxicity of arsenic (As) targets specific tissues of organisms, while the biotransportation of As among the tissues of fish remains poorly understood. In the present study, radiotracer techniques followed by a physiologically based pharmacokinetic (PBPK) modeling were applied to simulate the biotransportation (absorption, distribution, and elimination) of As-73(V) and biotransformation of As(V) in the marine medaka Oryzias melastigma after waterborne As exposure. Fish were simulated by a six-compartment model by assuming that blood was the intermediate exchange among different compartments (gill, intestine, liver, head, and carcass). Modeling suggested that intestine and gill were the uptake, exchange, as well as elimination sites of waterborne As, while carcass and head were the main storage sites. Intestine played a vital role in the metabolism of As(V) by biotransforming inorganic As into arsenobetaine (AsB), possibly because of the important role of gut microbiota. The correlation between the PBPK model constants and the As speciation (e.g., AsB %, inorganic As %, and methylated As %) indicated that AsB tended to be stored in the tissues rather than being depurated, while inorganic and methylated As were more easily transferred from tissues to the blood and eliminated. Modeling simulation coupling with biotransformation for the first time demonstrated that the fish intestine was the main metabolic site, and synthesis of AsB as mediated by the microbiota in the intestine contributed to the high As bioaccumulation in marine fish. |
| 资助机构 | National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [21876180, 41876133]; Guangzhou Science and Technology Plan Projects [201710010173]; 100 Talents Project of Guanzhou University [RQ202057]; Innovation Academy of South China Sea Ecology and Environmental Engineering, Chinese Academy of Sciences [ISEE2018ZD02]; Science and Technology Planning Project of Guangdong Province, China [2017B0303014052] ; National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [21876180, 41876133]; Guangzhou Science and Technology Plan Projects [201710010173]; 100 Talents Project of Guanzhou University [RQ202057]; Innovation Academy of South China Sea Ecology and Environmental Engineering, Chinese Academy of Sciences [ISEE2018ZD02]; Science and Technology Planning Project of Guangdong Province, China [2017B0303014052] |
| 源URL | [http://ir.scsio.ac.cn/handle/344004/18396]  |
| 专题 | 南海海洋研究所_中科院海洋生物资源可持续利用重点实验室 |
| 作者单位 | 1.City Univ Hong Kong, Sch Energy & Environm, Kowloon, Hong Kong 999077, Peoples R China 2.Guangzhou Univ, Minist Educ, Inst Environm Res, Greater Bay Area, Guangzhou 510006, Peoples R China 3.Guangzhou Univ, Minist Educ, Key Lab Water Qual & Conservat Pearl River Delta, Guangzhou 510006, Peoples R China 4.Chinese Acad Sci, South China Sea Inst Oceanol, Guangdong Prov Key Lab Appl Marine Biol, Key Lab Trop Marine Bioresources & Ecol, Guangzhou 510301, Peoples R China 5.Xiamen Univ, Coll Environm & Ecol, Minist Educ, Key Lab Coastal & Wetland Ecosyst, Xiamen 361102, Peoples R China 6.City Univ Hong Kong, State Key Lab Marine Pollut, Kowloon, Hong Kong 999077, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhang, Wei,Song, Dongdong,Tan, Qiao-Guo,et al. Physiologically Based Pharmacokinetic Model for the Biotransportation of Arsenic in Marine Medaka (Oryzias melastigma)[J]. ENVIRONMENTAL SCIENCE & TECHNOLOGY,2020,54(12):7485, 7493. |
| APA | Zhang, Wei,Song, Dongdong,Tan, Qiao-Guo,Wang, Wen-Xiong,&Zhang, Li.(2020).Physiologically Based Pharmacokinetic Model for the Biotransportation of Arsenic in Marine Medaka (Oryzias melastigma).ENVIRONMENTAL SCIENCE & TECHNOLOGY,54(12),7485. |
| MLA | Zhang, Wei,et al."Physiologically Based Pharmacokinetic Model for the Biotransportation of Arsenic in Marine Medaka (Oryzias melastigma)".ENVIRONMENTAL SCIENCE & TECHNOLOGY 54.12(2020):7485. |
入库方式： OAI收割
来源：南海海洋研究所
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