Antimicrobial tunicamycin derivatives from the deep sea-derived Streptomyces xinghaiensis SCSIO S15077
文献类型：期刊论文
| 作者 | Zhang, Shanwen1; Gui, Chun1; Shao, Mingwei1; Kumar, Pachaiyappan Saravana; Huang, Hongbo; Ju, Jianhua1 |
| 刊名 | NATURAL PRODUCT RESEARCH
 |
| 出版日期 | 2020 |
| 卷号 | 34期号:11页码:1499 |
| 关键词 | Tunicamycin nucleotide antibiotics Streptomyces xinghaiensis antimicrobial activity |
| ISSN号 | 1478-6419 |
| DOI | 10.1080/14786419.2018.1493736 |
| 英文摘要 | Tunicamycin E (1), featuring a methyl substitution at C-10 ', was isolated from marine-derived Streptomyces xinghaiensis SCSIO S15077 originated from the South China Sea sediment together with six known compounds, tunicamycin B (2), tunicamycin X (3), tunicamycin A (4), streptovirudin D-2 (5), tunicamycin C (6), and tunicamycin C-3 (7). The structure of compound 1 was elucidated by detailed spectroscopic data analyses. All the compounds exhibited strong to moderate antibacterial activity against Gram-positive bacteria Bacillus thuringiensis BT01 and B. thuringiensis W102 with MIC values ranging from 0.008 to 2 mu g/mL. Moreover, compounds 1-7 exhibited moderate antifungal activity against Candida albicans ATCC 96901 and C. albicans CMCC (F) 98001 with MIC values ranging from 2 to 32 mu g/mL. This is the first report that tunicamycins exhibit antimicrobial activities against B. thuringiensis, C. albicans CMCC (F) 98001 and a fluconazole resistant strain C. albicans ATCC 96901. |
| 资助机构 | National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81425022, U1501223, U1706206]; Natural Science Foundation of Guangdong ProvinceNational Natural Science Foundation of Guangdong Province [2016A030312014] ; National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81425022, U1501223, U1706206]; Natural Science Foundation of Guangdong ProvinceNational Natural Science Foundation of Guangdong Province [2016A030312014] |
| 源URL | [http://ir.scsio.ac.cn/handle/344004/18404]  |
| 专题 | 南海海洋研究所_中科院海洋生物资源可持续利用重点实验室 |
| 作者单位 | 1.Chinese Acad Sci, South China Sea Inst Oceanol, CAS Key Lab Trop Marine Bioresources & Ecol, Guangdong Key Lab Marine Mat Med,RNAM Ctr Marine, Guangzhou, Peoples R China 2.Univ Chinese Acad Sci, Beijing, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhang, Shanwen,Gui, Chun,Shao, Mingwei,et al. Antimicrobial tunicamycin derivatives from the deep sea-derived Streptomyces xinghaiensis SCSIO S15077[J]. NATURAL PRODUCT RESEARCH,2020,34(11):1499, 1504. |
| APA | Zhang, Shanwen,Gui, Chun,Shao, Mingwei,Kumar, Pachaiyappan Saravana,Huang, Hongbo,&Ju, Jianhua.(2020).Antimicrobial tunicamycin derivatives from the deep sea-derived Streptomyces xinghaiensis SCSIO S15077.NATURAL PRODUCT RESEARCH,34(11),1499. |
| MLA | Zhang, Shanwen,et al."Antimicrobial tunicamycin derivatives from the deep sea-derived Streptomyces xinghaiensis SCSIO S15077".NATURAL PRODUCT RESEARCH 34.11(2020):1499. |
入库方式： OAI收割
来源：南海海洋研究所
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