Identification and bioactivity evaluation of secondary metabolites from Antarctic-derived Penicillium chrysogenum CCTCC M 2020019
文献类型：期刊论文
| 作者 | Khan, Imran2; Zhang, Haibo1; Liu, Wei3; Zhang, Liping1; Peng, Fang4; Chen, Yuchan5; Zhang, Qingbo1; Zhang, Guangtao1; Zhang, Weimin5; Zhang, Changsheng1 |
| 刊名 | RSC ADVANCES
 |
| 出版日期 | 2020 |
| 卷号 | 10期号:35页码:20738 |
| DOI | 10.1039/d0ra03529g |
| 英文摘要 | Extracts from Antarctic-derived Penicillium chrysogenum CCTCC M 2020019 showed potent antibacterial bioactivities. We report herein the isolation of chrysonin (1), a new compound containing a pair of enantiomers 6S- and 6R-chrysonin (1a and 1b) featuring an unprecedented eight-membered heterocycle fused with a benzene ring. Compound 2, a mixture consisting of a new zwitterionic compound chrysomamide (2a) and N-[2-trans-(4-hydroxyphenyl) ethenyl] formamide (2b) in a ratio around 1 : 2.8, was isolated together with seven known compounds 3-9. Chemical structures of all compounds were determined by comprehensive spectroscopic analyses. The isolated compounds were evaluated for antimicrobial, cytotoxic and alpha-glucosidase inhibition activities. Chrysonin (1) showed moderate alpha-glucosidase inhibitory activity. The dominant product xanthocillin X (4) displayed potent inhibition activities against Gram-negative pathogens Acinetobacter baumannii, Klebsiella pneumoniae, and Pseudomonas aeruginosa with MIC values at 0.125 mu g mL(-1). Xanthocillins X (4) and Y1 (5) also showed significant cytotoxicities against four cancer cell lines with IC50 values ranging from 0.26 to 5.04 mu M. This study highlights that microorganisms from polar regions are emerging as a new resource for the discovery of natural products combating human pathogens. |
| 资助机构 | National Key Research & Development Program of China [2018YFC1406705, 2018YFC1406704]; National Natural Science Foundation of China (NSFC)National Natural Science Foundation of China (NSFC) [81872778, 41406183]; Key Special Project for Introduced Talents Team of Southern Marine Science and Engineering Guangdong Laboratory (Guangzhou) [GML2019ZD0406] ; National Key Research & Development Program of China [2018YFC1406705, 2018YFC1406704]; National Natural Science Foundation of China (NSFC)National Natural Science Foundation of China (NSFC) [81872778, 41406183]; Key Special Project for Introduced Talents Team of Southern Marine Science and Engineering Guangdong Laboratory (Guangzhou) [GML2019ZD0406] |
| 源URL | [http://ir.scsio.ac.cn/handle/344004/18409]  |
| 专题 | 南海海洋研究所_中科院海洋生物资源可持续利用重点实验室 |
| 作者单位 | 1.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 2.Chinese Acad Sci, Key Lab Trop Marine Bioresources & Ecol, Guangdong Key Lab Marine Mat Med, RNAM Ctr Marine Microbiol,South China Sea Inst Oc, 164 West Xingang Rd, Guangzhou 510301, Peoples R China 3.Southern Marine Sci & Engn Guangdong Lab Guangzho, 1119 Haibin Rd, Guangzhou 511458, Peoples R China 4.Sun Yat Sen Univ, Sch Marine Sci, South China Sea Resource Exploitat & Protect Coll, Guangzhou 510006, Peoples R China 5.Wuhan Univ, China Ctr Type Culture Collect, Wuhan 430072, Peoples R China 6.Guangdong Inst Microbiol, State Key Lab Appl Microbiol Southern China, 100 Cent Xianlie Rd, Guangzhou 510070, Peoples R China |
| 推荐引用方式 GB/T 7714 | Khan, Imran,Zhang, Haibo,Liu, Wei,et al. Identification and bioactivity evaluation of secondary metabolites from Antarctic-derived Penicillium chrysogenum CCTCC M 2020019[J]. RSC ADVANCES,2020,10(35):20738, 20744. |
| APA | Khan, Imran.,Zhang, Haibo.,Liu, Wei.,Zhang, Liping.,Peng, Fang.,...&Zhang, Changsheng.(2020).Identification and bioactivity evaluation of secondary metabolites from Antarctic-derived Penicillium chrysogenum CCTCC M 2020019.RSC ADVANCES,10(35),20738. |
| MLA | Khan, Imran,et al."Identification and bioactivity evaluation of secondary metabolites from Antarctic-derived Penicillium chrysogenum CCTCC M 2020019".RSC ADVANCES 10.35(2020):20738. |
入库方式： OAI收割
来源：南海海洋研究所
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