Ansamycin derivatives from the marine-derived Streptomyces sp. SCSGAA 0027 and their cytotoxic and antiviral activities
文献类型：期刊论文
| 作者 | Nong, Xu-Hua; Tu, Zheng-Chao; Qi, Shu-Hua |
| 刊名 | BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
 |
| 出版日期 | 2020 |
| 卷号 | 30期号:11页码:127168 |
| 关键词 | Streptomyces sp. Ansamycin Herbimycin Divergolide Cytotoxicity anti-HSV-1 activity Hsp90 inhibition |
| ISSN号 | 0960-894X |
| DOI | 10.1016/j.bmcl.2020.127168 |
| 英文摘要 | Fourteen ansamycin derivatives including seven new herbimycins G-L (1-6) and divergolide O (7), and seven known analogues were isolated from a culture broth of the marine-derived Streptomyces sp. SCSGAA 0027. Their complete structures were determined by detailed analysis of spectroscopic data and quantum chemical calculations. Compounds 1-5 and 7 featured an additional eight-membered O-heterocycle that has rarely been reported for ansamycins, and the Z,Z- and E,E-configurations for Delta(2),Delta(4) were reported for the first time in geldanamycin analogues. Compound 1 exhibited weak inhibition activity towards Hsp90 alpha with an IC50 value of 96 mu M, 2-5 showed mild cytotoxicity against four human cancer cell lines with IC50 values ranging from 13 mu M to 86 mu M, and 7 had moderate anti-HSV-1 activity with an IC50 value of 19 mu M and very weak cytotoxicity towards Vero cell. The possible biosynthetic pathways for 1-5 were proposed. And their structure-bioactivity relationship was also discussed. |
| 资助机构 | Guangdong Provincial-level Special Funds for Promoting High-quality Economic Development [2020032]; National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [41606100, 81673326]; Key Special Project for Introduced Talents Team of Southern Marine Science and Engineering Guangdong Laboratory (Guangzhou) [GML2019ZD0406] ; Guangdong Provincial-level Special Funds for Promoting High-quality Economic Development [2020032]; National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [41606100, 81673326]; Key Special Project for Introduced Talents Team of Southern Marine Science and Engineering Guangdong Laboratory (Guangzhou) [GML2019ZD0406] |
| 源URL | [http://ir.scsio.ac.cn/handle/344004/18414]  |
| 专题 | 南海海洋研究所_中科院海洋生物资源可持续利用重点实验室 |
| 作者单位 | 1.[Nong, Xu-Hua 2.Chinese Acad Sci, Key Lab Trop Marine Bioresources & Ecol Guangdong, South China Sea Inst Oceanol, Key Lab Marine Mat Med,RNAM Ctr Marine Microbiol, 164 West Xingang Rd, Guangzhou 510301, Guangdong, Peoples R China 3.[Nong, Xu-Hua 4.Southern Marine Sci & Engn Guangdong Lab Guangzho, 1119 Haibin Rd, Guangzhou 511458, Peoples R China 5.Chinese Acad Sci, Guangzhou Inst Biomed & Hlth, 190 Kaiyuan Rd, Guangzhou 510530, Guangdong, Peoples R China |
| 推荐引用方式 GB/T 7714 | Nong, Xu-Hua,Tu, Zheng-Chao,Qi, Shu-Hua. Ansamycin derivatives from the marine-derived Streptomyces sp. SCSGAA 0027 and their cytotoxic and antiviral activities[J]. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,2020,30(11):127168. |
| APA | Nong, Xu-Hua,Tu, Zheng-Chao,&Qi, Shu-Hua.(2020).Ansamycin derivatives from the marine-derived Streptomyces sp. SCSGAA 0027 and their cytotoxic and antiviral activities.BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,30(11),127168. |
| MLA | Nong, Xu-Hua,et al."Ansamycin derivatives from the marine-derived Streptomyces sp. SCSGAA 0027 and their cytotoxic and antiviral activities".BIOORGANIC & MEDICINAL CHEMISTRY LETTERS 30.11(2020):127168. |
入库方式： OAI收割
来源：南海海洋研究所
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