Antitubercular Ilamycins from Marine-Derived Streptomyces atratus SCSIO ZH16 Delta ilaR
文献类型：期刊论文
| 作者 | Sun, Changli; Liu, Zhiyong6,7; Zhu, Xiangcheng4,5; Fan, Zhiying4,5; Huang, Xuanmei3; Wu, Qiaoling1; Zheng, Xiaohong; Qin, Xiangjing; Zhang, Tianyu6,7; Zhang, Hua3 |
| 刊名 | JOURNAL OF NATURAL PRODUCTS
 |
| 出版日期 | 2020 |
| 卷号 | 83期号:5页码:1646 |
| ISSN号 | 0163-3864 |
| DOI | 10.1021/acs.jnatprod.0c00151 |
| 英文摘要 | Tuberculosis (TB) ranks as the leading cause of death from a single infectious agent (ranking more lethal than HIV/AIDS) over the course of the past decade. More concerning is that reports of multi-drug-resistant (MDR) and extensively drug-resistant (XDR) strains of TB have been dramatically increasing. It continues to become ever more clear that novel anti-TB drugs with improved efficacies and reduced toxicities are urgently needed. We report here the discovery of 12 new ilamycin analogues, ilamycins G-R (1-12), bearing various nonproteinogenic amino acids, along with ilamycins E-1 (13) and F (14), from a 200 L scale culture of the marine-derived mutant actinomycete Streptomyces atratus SCSIO ZH16 Delta ilaR. Importantly, bioassays against Mycobacterium tuberculosis H37Rv revealed that all 12 new agents displayed antitubercular activities with MIC values ranging from 0.0096 to 10 mu M. The structures of 1-12 were elucidated on the basis of HRESIMS, 1D and 2D NMR, and X-ray single-crystal diffraction studies. In addition, compound 10 was found to be moderately cytotoxic against a panel of tumor human cell lines. From these data we can formulate tentative structure-activity relationships for the antitubercular and antitumor activities of the ilamycins. |
| 资助机构 | China NSFNational Natural Science Foundation of China (NSFC) [41706169, 31870046, 81973372, U1706206]; Guangdong NSFNational Natural Science Foundation of Guangdong Province [2016A030312014, 2018A0303130005]; National Key Research and Development Program of China [2019YFC0312503, 2018YFA0901903]; Special Funds for Economic Development of Marine Economy of Guangdong Province [GDME-2018C003]; CASChinese Academy of Sciences [YJ-KYYQ20170036]; National Mega-project of China for Innovative Drugs [2019ZX09721001-003-003]; Key Special Project for Introduced Talents Team of Southern Marine Science and Engineering Guangdong Laboratory (Guangzhou) [GML2019ZD0406]; Special Support Program for Training High-Level Talents in Guangdong [201528018]; Science and Technology Innovation Leader of Guangdong Province [2016TX03R095] ; China NSFNational Natural Science Foundation of China (NSFC) [41706169, 31870046, 81973372, U1706206]; Guangdong NSFNational Natural Science Foundation of Guangdong Province [2016A030312014, 2018A0303130005]; National Key Research and Development Program of China [2019YFC0312503, 2018YFA0901903]; Special Funds for Economic Development of Marine Economy of Guangdong Province [GDME-2018C003]; CASChinese Academy of Sciences [YJ-KYYQ20170036]; National Mega-project of China for Innovative Drugs [2019ZX09721001-003-003]; Key Special Project for Introduced Talents Team of Southern Marine Science and Engineering Guangdong Laboratory (Guangzhou) [GML2019ZD0406]; Special Support Program for Training High-Level Talents in Guangdong [201528018]; Science and Technology Innovation Leader of Guangdong Province [2016TX03R095] |
| 源URL | [http://ir.scsio.ac.cn/handle/344004/18422]  |
| 专题 | 南海海洋研究所_中科院海洋生物资源可持续利用重点实验室 |
| 作者单位 | 1.Chinese Acad Sci, CAS Key Lab Trop Marine Bioresources & Ecol, Guangdong Key Lab Marine Mat Med, RNAM Ctr Marine Microbiol,South China Sea Inst Oc, Guangzhou 510301, Peoples R China 2.Guangdong Med Univ, Guangdong Prov Key Lab Med Mol Diagnost, Inst Lab Med, Dongguan 523808, Peoples R China 3.Natl Engn Res Ctr Combinatorial Biosynth Drug Dis, Changsha 410013, Hunan, Peoples R China 4.Cent South Univ, Xiangya Int Acad Translat Med, Changsha 410013, Hunan, Peoples R China 5.Guangdong Hong Kong Macao Joint Lab Resp Infect D, Guangzhou 510530, Peoples R China 6.Chinese Acad Sci, Guangzhou Inst Biomed & Hlth, TB Res Lab, State Key Lab Resp Dis, Guangzhou 510530, Peoples R China 7.Univ Chinese Acad Sci, Coll Oceanol, Beijing, Peoples R China |
| 推荐引用方式 GB/T 7714 | Sun, Changli,Liu, Zhiyong,Zhu, Xiangcheng,et al. Antitubercular Ilamycins from Marine-Derived Streptomyces atratus SCSIO ZH16 Delta ilaR[J]. JOURNAL OF NATURAL PRODUCTS,2020,83(5):1646, 1657. |
| APA | Sun, Changli.,Liu, Zhiyong.,Zhu, Xiangcheng.,Fan, Zhiying.,Huang, Xuanmei.,...&Ma, Junying.(2020).Antitubercular Ilamycins from Marine-Derived Streptomyces atratus SCSIO ZH16 Delta ilaR.JOURNAL OF NATURAL PRODUCTS,83(5),1646. |
| MLA | Sun, Changli,et al."Antitubercular Ilamycins from Marine-Derived Streptomyces atratus SCSIO ZH16 Delta ilaR".JOURNAL OF NATURAL PRODUCTS 83.5(2020):1646. |
入库方式： OAI收割
来源：南海海洋研究所
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