Production of Antitubercular Depsipeptides via Biosynthetic Engineering of Cinnamoyl Units
文献类型：期刊论文
| 作者 | Yang, Zhijie1; Sun, Changli; Liu, Zhiyong3,4; Liu, Qing; Zhang, Tianyu1,3,4; Ju, Jianhua1; Ma, Junying |
| 刊名 | JOURNAL OF NATURAL PRODUCTS
 |
| 出版日期 | 2020 |
| 卷号 | 83期号:5页码:1666 |
| ISSN号 | 0163-3864 |
| DOI | 10.1021/acs.jnatprod.0c00194 |
| 英文摘要 | Two new cyclodecapeptides, atratumycins B (1) and C (2), containing substituted cinnamoyl side chains were generated by converging elements of the atratumycin (3) and atrovimycin (4) biosynthetic pathways. The structures of 1 and 2 were determined on the basis of HRESIMS, 1D and 2D NMR data, and X-ray single-crystal diffraction studies. Atratumycin B (1) is active against autoluminescent Mycobacterium tuberculosis H37Rv, displaying a minimum inhibitory concentration of 3.1 mu g/mL (2.3 mu M). |
| 资助机构 | National Key Research and Development Program of China [2018YFA0901903, 2019YFC0312503]; National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [31870046, U1706206, 81973372, 41706169]; National Natural Science Foundation of Guangdong ProvinceNational Natural Science Foundation of Guangdong Province [2016A030312014, 2018A0303130005]; Special Funds for Economic Development of Marine Economy of Guangdong Province [GDME-2018C003]; Rising Star Foundation of the South China Sea Institute of Oceanology [NHXX2019SW0101]; National Mega-project of China for Innovative Drugs [2019ZX09721001-003-003]; Science and Technology Innovation Leader of Guangdong Province [2016TX03R095] ; National Key Research and Development Program of China [2018YFA0901903, 2019YFC0312503]; National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [31870046, U1706206, 81973372, 41706169]; National Natural Science Foundation of Guangdong ProvinceNational Natural Science Foundation of Guangdong Province [2016A030312014, 2018A0303130005]; Special Funds for Economic Development of Marine Economy of Guangdong Province [GDME-2018C003]; Rising Star Foundation of the South China Sea Institute of Oceanology [NHXX2019SW0101]; National Mega-project of China for Innovative Drugs [2019ZX09721001-003-003]; Science and Technology Innovation Leader of Guangdong Province [2016TX03R095] |
| 源URL | [http://ir.scsio.ac.cn/handle/344004/18423]  |
| 专题 | 南海海洋研究所_中科院海洋生物资源可持续利用重点实验室 |
| 作者单位 | 1.Chinese Acad Sci, South China Sea Inst Oceanol, CAS Key Lab Trop Marine Bioresources & Ecol, Guangdong Key Lab Marine Mat Med,RNAM Ctr Marine, Guangzhou 510301, Peoples R China 2.Guangdong Hong Kong Macao Joint Lab Resp Infect D, Guangzhou 510530, Peoples R China 3.Chinese Acad Sci, Guangzhou Inst Biomed & Hlth, TB Res Lab, State Key Lab Resp Dis, Guangzhou 510530, Peoples R China 4.Univ Chinese Acad Sci, Coll Oceanol, Beijing 100049, Peoples R China |
| 推荐引用方式 GB/T 7714 | Yang, Zhijie,Sun, Changli,Liu, Zhiyong,et al. Production of Antitubercular Depsipeptides via Biosynthetic Engineering of Cinnamoyl Units[J]. JOURNAL OF NATURAL PRODUCTS,2020,83(5):1666, 1673. |
| APA | Yang, Zhijie.,Sun, Changli.,Liu, Zhiyong.,Liu, Qing.,Zhang, Tianyu.,...&Ma, Junying.(2020).Production of Antitubercular Depsipeptides via Biosynthetic Engineering of Cinnamoyl Units.JOURNAL OF NATURAL PRODUCTS,83(5),1666. |
| MLA | Yang, Zhijie,et al."Production of Antitubercular Depsipeptides via Biosynthetic Engineering of Cinnamoyl Units".JOURNAL OF NATURAL PRODUCTS 83.5(2020):1666. |
入库方式： OAI收割
来源：南海海洋研究所
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