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Heterologous expression of the trichostatin gene cluster and functional characterization of N-methyltransferase TsnB8

文献类型：期刊论文

作者Liu, Wei; Jannu, Vinay Gopal; Liu, Zhiwen; Zhang, Qingbo1; Jiang, Xiaodong; Ma, Liang1; Zhang, Wenjun1; Zhang, Changsheng1; Zhu, Yiguang1
刊名ORGANIC & BIOMOLECULAR CHEMISTRY
出版日期2020
卷号18期号:19页码:3649
ISSN号1477-0520
DOI10.1039/d0ob00617c
英文摘要Trichostatins are potent inhibitors of histone deacetylase (HDAC). In this work, a new trichostatin derivative isotrichostatin RK (1) and five known compounds trichostatin RK (2), JBIR-111 (3), 9179B (4), trichostatic acid (5) and trichostatin A (6) were isolated from marine-derived Streptomyces sp. SCSIO 40028. The biosynthetic gene cluster (tsnB) for trichostatins was identified from Streptomyces sp. SCSIO 40028 and validated by heterologous expression in Streptomyces lividans TK64. N-Methyltransferase TsnB8 was demonstrated to catalyze successive methyltransfer reactions by in vivo gene inactivation and in vitro enzyme assays.
资助机构National Key Research and Development Program of China [2018YFA0901903]; Chinese Academy of SciencesChinese Academy of Sciences [XDA13020302, QYZDJ-SSW-DQC004]; National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [31630004]; Key Special Project for Introduced Talents Team of Southern Marine Science and Engineering Guangdong Laboratory (Guangzhou) [GML2019ZD0406]; Qingdao National Laboratory for Marine Science and Technology [QNLM2016ORP0304]; Special Support Program for Training High-Level Talents in Guangdong [2019TQ05H299] ; National Key Research and Development Program of China [2018YFA0901903]; Chinese Academy of SciencesChinese Academy of Sciences [XDA13020302, QYZDJ-SSW-DQC004]; National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [31630004]; Key Special Project for Introduced Talents Team of Southern Marine Science and Engineering Guangdong Laboratory (Guangzhou) [GML2019ZD0406]; Qingdao National Laboratory for Marine Science and Technology [QNLM2016ORP0304]; Special Support Program for Training High-Level Talents in Guangdong [2019TQ05H299]
源URL[http://ir.scsio.ac.cn/handle/344004/18424]  
专题南海海洋研究所_中科院海洋生物资源可持续利用重点实验室
作者单位1.Chinese Acad Sci, South China Sea Inst Oceanol, Innovat Acad South China Sea Ecol & Environm Engn, Key Lab Trop Marine Rio Resources & Ecol,Guangdon, 164 West Xingang Rd, Guangzhou 510301, Peoples R China
2.Southern Marine Sci & Engn Guangdong Lab Guangzho, 1119 Haibin Rd, Guangzhou 511458, Peoples R China
推荐引用方式
GB/T 7714		 Liu, Wei,Jannu, Vinay Gopal,Liu, Zhiwen,et al. Heterologous expression of the trichostatin gene cluster and functional characterization of N-methyltransferase TsnB8[J]. ORGANIC & BIOMOLECULAR CHEMISTRY,2020,18(19):3649, 3653.
APA Liu, Wei.,Jannu, Vinay Gopal.,Liu, Zhiwen.,Zhang, Qingbo.,Jiang, Xiaodong.,...&Zhu, Yiguang.(2020).Heterologous expression of the trichostatin gene cluster and functional characterization of N-methyltransferase TsnB8.ORGANIC & BIOMOLECULAR CHEMISTRY,18(19),3649.
MLA Liu, Wei,et al."Heterologous expression of the trichostatin gene cluster and functional characterization of N-methyltransferase TsnB8".ORGANIC & BIOMOLECULAR CHEMISTRY 18.19(2020):3649.

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来源：南海海洋研究所

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