Ene-yne Hydroquinones from a Marine-derived Strain of the Fungus Pestalotiopsis neglecta with Effects on Liver X Receptor Alpha
文献类型：期刊论文
| 作者 | Wang, Jianjiao1,2; Liang, Zhi; Li, Kunlong1,2; Yang, Bin2; Liu, Yonghong2; Fang, Wei3; Tang, Lan; Zhou, Xuefeng2 |
| 刊名 | JOURNAL OF NATURAL PRODUCTS
 |
| 出版日期 | 2020 |
| 卷号 | 83期号:4页码:1258 |
| ISSN号 | 0163-3864 |
| DOI | 10.1021/acs.jnatprod.0c00050 |
| 英文摘要 | Seven unusual new ene-yne hydroquinones (1-3, 5-8), including three rare glycosylated derivatives named pestalotioquinosides A-C (6-8), were obtained from the marine-derived strain SCSIO41403 of the fungus Pestalotiopsis neglecta. Their structures including absolute configurations were elucidated by spectroscopic analysis and induced electronic circular dichroism experiments. In silico molecular docking and in vitro surface plasmon resonance studies showed that pestalotioquinoside C (8) could act as a liver X receptor alpha (LXR alpha) modulator. Further study showed that LXR target gene ABCA1 was significantly upregulated by 8, which revealed 8 as a potential LXR alpha agonist. |
| 资助机构 | National Key Research and Development Program of China [2019YFC0312503]; Drug Innovation Major Project of China [2018ZX09735001-002-003]; National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81973235, 21772210, 21977102]; Agricultural S&T innovation guidance project of Hubei Province Science and Technology Department [2018BBB327]; Guangdong Basic and Applied Basic Research Foundation [2019B151502042, 2018A0303130219] ; National Key Research and Development Program of China [2019YFC0312503]; Drug Innovation Major Project of China [2018ZX09735001-002-003]; National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81973235, 21772210, 21977102]; Agricultural S&T innovation guidance project of Hubei Province Science and Technology Department [2018BBB327]; Guangdong Basic and Applied Basic Research Foundation [2019B151502042, 2018A0303130219] |
| 源URL | [http://ir.scsio.ac.cn/handle/344004/18442]  |
| 专题 | 南海海洋研究所_中科院海洋生物资源可持续利用重点实验室 |
| 作者单位 | 1.Hubei Acad Agr Sci, Hubei Biopesticide Engn Res Ctr, Wuhan 430064, Peoples R China 2.Southern Med Univ, Guangdong Prov Key Lab New Drug Screening, Biopharmaceut, Sch Pharmaceut Sci, Guangzhou 510515, Peoples R China 3.Chinese Acad Sci, South China Sea Inst Oceanol, CAS Key Lab Trop Marine Bioresources & Ecol, Guangdong Key Lab Marine Mat Med, Guangzhou 510301, Peoples R China 4.Univ Chinese Acad Sci, Beijing 100049, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wang, Jianjiao,Liang, Zhi,Li, Kunlong,et al. Ene-yne Hydroquinones from a Marine-derived Strain of the Fungus Pestalotiopsis neglecta with Effects on Liver X Receptor Alpha[J]. JOURNAL OF NATURAL PRODUCTS,2020,83(4):1258, 1264. |
| APA | Wang, Jianjiao.,Liang, Zhi.,Li, Kunlong.,Yang, Bin.,Liu, Yonghong.,...&Zhou, Xuefeng.(2020).Ene-yne Hydroquinones from a Marine-derived Strain of the Fungus Pestalotiopsis neglecta with Effects on Liver X Receptor Alpha.JOURNAL OF NATURAL PRODUCTS,83(4),1258. |
| MLA | Wang, Jianjiao,et al."Ene-yne Hydroquinones from a Marine-derived Strain of the Fungus Pestalotiopsis neglecta with Effects on Liver X Receptor Alpha".JOURNAL OF NATURAL PRODUCTS 83.4(2020):1258. |
入库方式： OAI收割
来源：南海海洋研究所
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