The role of the chondroitin sulfate synthase-1 gene in the immune response of the pearl oyster Pinctada fucata
文献类型：期刊论文
| 作者 | Zhang, Hua1; Yi, Xuejie2; Guan, Yunyan1; Shi, Yu1; Ou, Zekui2; He, Maoxian1 |
| 刊名 | FISHERIES SCIENCE
 |
| 出版日期 | 2020 |
| 卷号 | 86期号:3页码:487 |
| 关键词 | Pinctada fucata ChSy-1 Gene cloning Immunity Nucleus grafting Infectious disease Immune challenge |
| ISSN号 | 0919-9268 |
| DOI | 10.1007/s12562-020-01420-6 |
| 英文摘要 | Chondroitin sulfate synthase-1 (ChSy-1) plays an important role in the synthesis and chain extension of chondroitin sulfate (CS). CS, a linear polysaccharide with high structural diversity, plays crucial roles in cell adhesion, morphogenesis and cell division in response to viral and bacterial infections. However, the role of ChSy-1 in the immune response remains unknown. In the present study, ChSy-1 from Pinctada fucata was identified. The deduced amino acid sequence of ChSy-1 contains a conserved domain, CHGN, which belongs to glycosyltransferase family A, and multiple sequence alignment revealed that CHGN shows evolutionary differences. Phylogenetic analysis indicated that ChSy-1 may be conserved evolutionarily. The nucleus grafting experiment showed that ChSy-1 possibly participates in wound repair and immune response to the graft. Lipopolysaccharide or polyinosinic:polycytidylic acid challenge and gene expression analysis especially suggested that ChSy-1 is involved in the immune response. The results of the present study indicate that ChSy-1 plays a role in the protection of the pearl oyster against infectious diseases. |
| 资助机构 | earmarked fund for the Modern Agro-industry Technology Research System [CARS-49] ; earmarked fund for the Modern Agro-industry Technology Research System [CARS-49] |
| 源URL | [http://ir.scsio.ac.cn/handle/344004/18445]  |
| 专题 | 南海海洋研究所_中科院海洋生物资源可持续利用重点实验室 |
| 作者单位 | 1.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 2.Chinese Acad Sci, South China Sea Inst Oceanol, Guangdong Prov Key Lab Appl Marine Biol, CAS Key Lab Trop Marine Bioresources & Ecol, Guangzhou 510301, Guangdong, Peoples R China 3.Chinese Acad Sci, Innovat Acad South China Sea Ecol & Environm Engn, Guangzhou 510301, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhang, Hua,Yi, Xuejie,Guan, Yunyan,et al. The role of the chondroitin sulfate synthase-1 gene in the immune response of the pearl oyster Pinctada fucata[J]. FISHERIES SCIENCE,2020,86(3):487, 494. |
| APA | Zhang, Hua,Yi, Xuejie,Guan, Yunyan,Shi, Yu,Ou, Zekui,&He, Maoxian.(2020).The role of the chondroitin sulfate synthase-1 gene in the immune response of the pearl oyster Pinctada fucata.FISHERIES SCIENCE,86(3),487. |
| MLA | Zhang, Hua,et al."The role of the chondroitin sulfate synthase-1 gene in the immune response of the pearl oyster Pinctada fucata".FISHERIES SCIENCE 86.3(2020):487. |
入库方式： OAI收割
来源：南海海洋研究所
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