New pestallic acids and diphenylketone derivatives from the marine alga-derived endophytic fungus Pestalotiopsis neglecta SCSIO41403
文献类型：期刊论文
| 作者 | Wang Jianjiao1,3; Peng Qingyun1,3; Yao Xingang4; Liu Yonghong1,3; Zhou Xuefeng1 |
| 刊名 | JOURNAL OF ANTIBIOTICS
 |
| 出版日期 | 2020 |
| 卷号 | 73期号:8页码:585 |
| ISSN号 | 0021-8820 |
| DOI | 10.1038/s41429-020-0308-3 |
| 英文摘要 | Three new carboxylic acid derivatives, pestallic acids F and G (1 and 2), pestalotiopyrone N (3), and a new diphenylketone derivative named neopestalone (5) were obtained from the liquid cultures of marine alga-derived endophytic fungus Pestalotiopsis neglecta SCSIO41403, along with six known compounds (4, 6-10). The structures of those new compounds were elucidated mainly by analysis of their NMR and MS data. The isolated compounds were evaluated for their anti-Dengue virus and COX-2 inhibitory activities, and two diphenylketone derivatives (5 and 6) exhibited obvious COX-2 inhibitory activities, with the IC50 values being 5.8 and 3.4 mu M, respectively. |
| 资助机构 | Drug Innovation Major Project of China [2018ZX09735001-002003]; National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81973235, 21772210, 21977102]; Guangdong Basic and Applied Basic Research Foundation [2019B151502042, 2018A0303130219]; National Key Research and Development Program of China [2019YFC0312503] ; Drug Innovation Major Project of China [2018ZX09735001-002003]; National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81973235, 21772210, 21977102]; Guangdong Basic and Applied Basic Research Foundation [2019B151502042, 2018A0303130219]; National Key Research and Development Program of China [2019YFC0312503] |
| 源URL | [http://ir.scsio.ac.cn/handle/344004/18452]  |
| 专题 | 南海海洋研究所_中科院海洋生物资源可持续利用重点实验室 |
| 作者单位 | 1.Chinese Acad Sci, CAS Key Lab Trop Marine Bioresources & Ecol, Guangdong Key Lab Marine Mat Med, South China Sea Inst Oceanol, Guangzhou 510301, Peoples R China 2.Southern Med Univ, Guangzhou Key Lab Drug Res Emerging Virus Prevent, Guangdong Prov Key Lab New Drug Screening, Sch Pharmaceut Sci,State Key Lab Organ Failure Re, Guangzhou 510515, Peoples R China 3.Southern Marine Sci & Engn Guangdong Lab Guangzho, Guangzhou 511458, Peoples R China 4.Univ Chinese Acad Sci, Beijing 100049, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wang Jianjiao,Peng Qingyun,Yao Xingang,et al. New pestallic acids and diphenylketone derivatives from the marine alga-derived endophytic fungus Pestalotiopsis neglecta SCSIO41403[J]. JOURNAL OF ANTIBIOTICS,2020,73(8):585, 588. |
| APA | Wang Jianjiao,Peng Qingyun,Yao Xingang,Liu Yonghong,&Zhou Xuefeng.(2020).New pestallic acids and diphenylketone derivatives from the marine alga-derived endophytic fungus Pestalotiopsis neglecta SCSIO41403.JOURNAL OF ANTIBIOTICS,73(8),585. |
| MLA | Wang Jianjiao,et al."New pestallic acids and diphenylketone derivatives from the marine alga-derived endophytic fungus Pestalotiopsis neglecta SCSIO41403".JOURNAL OF ANTIBIOTICS 73.8(2020):585. |
入库方式： OAI收割
来源：南海海洋研究所
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