Antioxidant CPA-type indole alkaloids produced from the deep-sea derived fungusAspergillussp. SCSIO 41024
文献类型：期刊论文
| 作者 | Chen, Wei-Hao; Li, Kun-Long; Lin, Xiu-Ping; Liao, Sheng-Rong; Yang, Bin; Zhou, Xue-Feng; Wang, Jun-Jian; Liu, Yong-Hong; Wang, Jun-Feng |
| 刊名 | NATURAL PRODUCT RESEARCH
 |
| 关键词 | Deep-sea derived Aspergillus indole alkaloid cyclopiazonic acid antioxidative activity |
| ISSN号 | 1478-6419 |
| DOI | 10.1080/14786419.2020.1749614 |
| 英文摘要 | Twelve indole alkaloids, including alpha-cyclopiazonic acid (CPA) (1), nine 2-oxo indole CPA derivatives (2-10), and two open-ring indole CPA derivatives (11and12), were isolated from the fermentation broth of a deep-sea derived fungusAspergillussp. SCSIO 41024. Their structures and absolute configurations were elucidated mainly by using extensive NMR spectroscopic, mass spectrometric and single crystal X-ray diffraction analysis. To the best of our knowledge, the crystallographic data of3and7were firstly reported, and the absolute configuration of3was confirmed for the first time by the single crystal X-ray diffraction analysis. Most isolated compounds were tested for their antimicrobial, antitumor and radical scavenging activities. In addition, compounds1,2and11showed moderate antioxidative activity against DPPH with IC(50)values of 190.1, 31.9, 228.4 mu g/mL, respectively. |
| 资助机构 | National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [21772210, 81872891, 41776169]; Institution of South China Sea Ecology and Environmental Engineering, CAS [ISEE2018PY04]; Guangdong MEPP Fund [GDOE[2019]A28]; Pearl River S&T Nova Program of Guangzhou [201710010136]; Guangzhou Science and Technology Project [201804010462] ; National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [21772210, 81872891, 41776169]; Institution of South China Sea Ecology and Environmental Engineering, CAS [ISEE2018PY04]; Guangdong MEPP Fund [GDOE[2019]A28]; Pearl River S&T Nova Program of Guangzhou [201710010136]; Guangzhou Science and Technology Project [201804010462] |
| 源URL | [http://ir.scsio.ac.cn/handle/344004/18455]  |
| 专题 | 南海海洋研究所_中科院海洋生物资源可持续利用重点实验室 |
| 作者单位 | 1.Liao, Sheng-Rong 2.[Chen, Wei-Hao 3.Li, Kun-Long 4.Lin, Xiu-Ping 5.Yang, Bin 6.Zhou, Xue-Feng 7.Liu, Yong-Hong 8.Chinese Acad Sci, South China Sea Inst Oceanol, Guangdong Key Lab Marine Mat Med, CAS Key Lab Trop Marine Bioresources & Ecol, Guangzhou, Peoples R China 9.[Chen, Wei-Hao 10.Li, Kun-Long |
| 推荐引用方式 GB/T 7714 | Chen, Wei-Hao,Li, Kun-Long,Lin, Xiu-Ping,et al. Antioxidant CPA-type indole alkaloids produced from the deep-sea derived fungusAspergillussp. SCSIO 41024[J]. NATURAL PRODUCT RESEARCH. |
| APA | Chen, Wei-Hao.,Li, Kun-Long.,Lin, Xiu-Ping.,Liao, Sheng-Rong.,Yang, Bin.,...&Wang, Jun-Feng. |
| MLA | Chen, Wei-Hao,et al."Antioxidant CPA-type indole alkaloids produced from the deep-sea derived fungusAspergillussp. SCSIO 41024".NATURAL PRODUCT RESEARCH |
入库方式： OAI收割
来源：南海海洋研究所
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