Four new steroids from the marine soft coral-derived fungus Pencillium sp. SCSIO41201
文献类型：期刊论文
| 作者 | Long Lie-Yi; Wang Jun-Feng; Liao Sheng-Rong; Lin Xiu-Ping; Zhou Xue-Feng; Li Yun-Qiu; Yang Bin; Liu Yong-Hong |
| 刊名 | CHINESE JOURNAL OF NATURAL MEDICINES
 |
| 出版日期 | 2020 |
| 卷号 | 18期号:4页码:250 |
| 关键词 | Soft corals Marine fungus Penicillium sp. Steroids Penicildione |
| ISSN号 | 2095-6975 |
| DOI | 10.1016/S1875-5364(20)30030-3 |
| 英文摘要 | Penicildiones A-D (1-4), four new steroids derivatives together with three known compounds including 16 alpha-methylpregna-17 alpha,19-dihydroxy-(9,11)-epoxy-4-ene-3,18-dione-20-acetoxy (5), stachybotrylactone B (6) and stachybotrin (7) were isolated from the soft coral-derived fungus Penicillium sp. SCSI041201, cultured in the 1% NaCl PDB substrate. Their structures were determined through spectroscopic methods and X-ray crystallography. Biological evaluation results revealed that 6 exhibited significant cytotoxic activity against HL-60, K562, MOLT-4, ACHN, 786-O, and OS-RC-2 cell lines with IC50 values of 5.23, 4.12, 4.31, 23.55, 7.65 and 10.81 mu mol.L-1, respectively, while other compounds showed weak or no cytotoxicity at 50 mu mol.L-1. |
| 资助机构 | National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [21977102, 81973235, 81860626, 21772210, 41776169]; Guangzhou Science and Technology Project [201804010462]; Natural Science Foundation of Guangdong ProvinceNational Natural Science Foundation of Guangdong Province [2018A0303130219]; Special Funds for Promoting Economic Development (Marine Economic Development) of Guangdong Province [GDOE[2019]A28]; National Major Scientific and Technological Special Project for Significant New Drugs Development [2018ZX09735001-002-003]; Institution of South China Sea Ecology and Environmental Engineering [ISEE2018PY04] ; National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [21977102, 81973235, 81860626, 21772210, 41776169]; Guangzhou Science and Technology Project [201804010462]; Natural Science Foundation of Guangdong ProvinceNational Natural Science Foundation of Guangdong Province [2018A0303130219]; Special Funds for Promoting Economic Development (Marine Economic Development) of Guangdong Province [GDOE[2019]A28]; National Major Scientific and Technological Special Project for Significant New Drugs Development [2018ZX09735001-002-003]; Institution of South China Sea Ecology and Environmental Engineering [ISEE2018PY04] |
| 源URL | [http://ir.scsio.ac.cn/handle/344004/18463]  |
| 专题 | 南海海洋研究所_中科院海洋生物资源可持续利用重点实验室 |
| 作者单位 | 1.Chinese Acad Sci, South China Branch, Innovat Acad Drug Discovery & Dev, Guangzhou 510650, Peoples R China 2.[Long Lie-Yi 3.Wang Jun-Feng 4.Liao Sheng-Rong 5.Lin Xiu-Ping 6.Zhou Xue-Feng 7.Yang Bin 8.Chinese Acad Sci, South China Sea Inst Oceanol, CAS Key Lab Trop Marine Bioresources & Ecol, Guangdong Key Lab Marine Mat Med, Guangzhou 510301, Peoples R China 9.[Long Lie-Yi 10.Univ Chinese Acad Sci, Beijing 100049, Peoples R China |
| 推荐引用方式 GB/T 7714 | Long Lie-Yi,Wang Jun-Feng,Liao Sheng-Rong,et al. Four new steroids from the marine soft coral-derived fungus Pencillium sp. SCSIO41201[J]. CHINESE JOURNAL OF NATURAL MEDICINES,2020,18(4):250, 255. |
| APA | Long Lie-Yi.,Wang Jun-Feng.,Liao Sheng-Rong.,Lin Xiu-Ping.,Zhou Xue-Feng.,...&Liu Yong-Hong.(2020).Four new steroids from the marine soft coral-derived fungus Pencillium sp. SCSIO41201.CHINESE JOURNAL OF NATURAL MEDICINES,18(4),250. |
| MLA | Long Lie-Yi,et al."Four new steroids from the marine soft coral-derived fungus Pencillium sp. SCSIO41201".CHINESE JOURNAL OF NATURAL MEDICINES 18.4(2020):250. |
入库方式： OAI收割
来源：南海海洋研究所
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