Julichrome Monomers from Marine Gastropod Mollusk-Associated Streptomyces and Stereochemical Revision of Julichromes Q(3.5) and Q(3.3)
文献类型：期刊论文
| 作者 | Dong, Yuliang1; Ding, Wenjuan1,2; Sun, Changli1; Ji, Xiaoqi1,2; Ling, Chunyao1; Zhou, Zhenbin1,2; Chen, Zhiyun1; Chen, Xuehong; Ju, Jianhua1,2 |
| 刊名 | CHEMISTRY & BIODIVERSITY
 |
| 出版日期 | 2020 |
| 卷号 | 17期号:4页码:e2000057 |
| 关键词 | julichromes absolute configuration structure revision antibacterial activity biological activity |
| ISSN号 | 1612-1872 |
| DOI | 10.1002/cbdv.202000057 |
| 英文摘要 | Two julichrome monomers, julichromes Q(11) (1) and Q(12) (2), along with five known julichromes (Q(10), Q(3).(5), Q(3).(3), Q(6).(6), Q(6), 3-7) and four known anthraquinones (chrysophanol, 4-acetylchrysophanol, islandicin, huanglongmycin A, 8-11), were isolated from the marine gastropod mollusk Batillaria zonalis-associated Streptomyces sampsonii SCSIO 054. This is the first report of julichromes isolated from a marine source. Extensive dissection of 1D and 2D NMR datasets combined with X-ray crystallography enabled rigorous elucidation of the previously reported configurations of julichrome Q(3).(5) (4) and related julichrome Q(3).(3) (5); both of the configuration at C(9) needs to be revised. In addition, julichrome Q(12) (2) was found to display antibacterial activity against Micrococcus luteus and Bacillus subtilis with MICs of 2.0 and 8.0 mu g mL(-1); four compounds (1, 3, 6, 7) also showed inhibitory activities against an array of methicillin-resistant Staphylococcus aureus, S. aureus and S. simulans AKA1 with MIC values ranging from 8 to 64 mu g mL(-1). |
| 资助机构 | Chinese Academy of SciencesChinese Academy of Sciences [XDA13020302]; National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [U1706206]; Natural Science Foundation of Guangdong ProvinceNational Natural Science Foundation of Guangdong Province [2016 A030312014]; National Key R&D Program of China [2019YFC0312503] ; Chinese Academy of SciencesChinese Academy of Sciences [XDA13020302]; National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [U1706206]; Natural Science Foundation of Guangdong ProvinceNational Natural Science Foundation of Guangdong Province [2016 A030312014]; National Key R&D Program of China [2019YFC0312503] |
| 源URL | [http://ir.scsio.ac.cn/handle/344004/18465]  |
| 专题 | 南海海洋研究所_中科院海洋生物资源可持续利用重点实验室 |
| 作者单位 | 1.Qingdao Univ, Sch Basic Med, Qingdao 266071, Peoples R China 2.Chinese Acad Sci, South China Sea Inst Oceanol, Guangdong Key Lab Marine Mat Med, CAS Key Lab Trop Marine Bioresources & Ecol, 164 West Xingang Rd, Guangzhou 510301, Peoples R China 3.Univ Chinese Acad Sci, Coll Oceanog, Beijing 100049, Peoples R China |
| 推荐引用方式 GB/T 7714 | Dong, Yuliang,Ding, Wenjuan,Sun, Changli,et al. Julichrome Monomers from Marine Gastropod Mollusk-Associated Streptomyces and Stereochemical Revision of Julichromes Q(3.5) and Q(3.3)[J]. CHEMISTRY & BIODIVERSITY,2020,17(4):e2000057. |
| APA | Dong, Yuliang.,Ding, Wenjuan.,Sun, Changli.,Ji, Xiaoqi.,Ling, Chunyao.,...&Ju, Jianhua.(2020).Julichrome Monomers from Marine Gastropod Mollusk-Associated Streptomyces and Stereochemical Revision of Julichromes Q(3.5) and Q(3.3).CHEMISTRY & BIODIVERSITY,17(4),e2000057. |
| MLA | Dong, Yuliang,et al."Julichrome Monomers from Marine Gastropod Mollusk-Associated Streptomyces and Stereochemical Revision of Julichromes Q(3.5) and Q(3.3)".CHEMISTRY & BIODIVERSITY 17.4(2020):e2000057. |
入库方式： OAI收割
来源：南海海洋研究所
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