Inhibition of cellular inflammatory mediator production and amelioration of learning deficit in flies by deep sea Aspergillus-derived cyclopenin
文献类型：期刊论文
| 作者 | Wang, Liyan; Li, Mengjie; Lin, Yinzhi1,2; Du, Shuwen3; Liu, Zhenyu3; Ju, Jianhua4; Suzuki, Hiromi5; Sawada, Makoto5; Umezawa, Kazuo1 |
| 刊名 | JOURNAL OF ANTIBIOTICS
 |
| 出版日期 | 2020 |
| 卷号 | 73期号:9页码:622 |
| ISSN号 | 0021-8820 |
| DOI | 10.1038/s41429-020-0302-9 |
| 英文摘要 | In the course of screening lipopolysaccharide (LPS)-induced nitric oxide (NO) production inhibitors, two related benzodiazepine derivatives, cyclopenol and cyclopenin, were isolated from the extract of a deep marine-derived fungal strain, Aspergillus sp. SCSIOW2. Cyclopenol and cyclopenin inhibited the LPS-induced formation of NO and secretion of IL-6 in RAW264.7 cells at nontoxic concentrations. In terms of the mechanism underlying these effects, cyclopenol and cyclopenin were found to inhibit the upstream signal of NF-kappa B activation. These compounds also inhibited the expression of IL-1 beta, IL-6, and inducible nitric oxide synthase (iNOS) in mouse microglia cells, macrophages in the brain. In relation to the cause of Alzheimer's disease, amyloid-beta-peptide is known to induce inflammation in the brain. Therefore, the present study investigated the ameliorative effects of these inhibitors on an in vivo Alzheimer's model using flies. Learning deficits were induced by the overexpression of amyloid-beta 42 in flies, and cyclopenin but not cyclopenol was found to rescue learning impairment. Therefore, novel anti-inflammatory activities of cyclopenin were identified, which may be useful as a candidate of anti-inflammatory agents for neurodegenerative diseases. |
| 资助机构 | National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [41276136]; Science and Technology Project of Shenzhen City; Shenzhen Bureau of Science, Technology, and Information [JCYJ20130408172946974]; JSPS KAKENHI of JapanMinistry of Education, Culture, Sports, Science and Technology, Japan (MEXT)Japan Society for the Promotion of ScienceGrants-in-Aid for Scientific Research (KAKENHI) [17K01967]; AMED, Japan [JP18fk0310118] ; National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [41276136]; Science and Technology Project of Shenzhen City; Shenzhen Bureau of Science, Technology, and Information [JCYJ20130408172946974]; JSPS KAKENHI of JapanMinistry of Education, Culture, Sports, Science and Technology, Japan (MEXT)Japan Society for the Promotion of ScienceGrants-in-Aid for Scientific Research (KAKENHI) [17K01967]; AMED, Japan [JP18fk0310118] |
| 源URL | [http://ir.scsio.ac.cn/handle/344004/18473]  |
| 专题 | 南海海洋研究所_中科院海洋生物资源可持续利用重点实验室 |
| 作者单位 | 1.Shenzhen Univ, Shenzhen Key Lab Marine Bioresource & Ecoenvironm, Coll Life Sci & Oceanog, Shenzhen 518060, Peoples R China 2.Aichi Med Univ, Sch Med, Dept Mol Target Med, Nagakute, Aichi 4801195, Japan 3.Aichi Med Univ, Sch Med, Dept Microbiol & Immunol, Nagakute, Aichi 4801195, Japan 4.Beijing JoeKai Biotech LLC, Beijing 10094, Peoples R China 5.Chinese Acad Sci, South China Sea Inst Oceanol, RNAM Ctr Marine Microbiol, Key Lab Trop Marine Bioresources & Ecol, Guangzhou 510301, Guangdong, Peoples R China 6.Nagoya Univ, Environm Med Res Inst, Brain Funct, Nagoya, Aichi 4648601, Japan |
| 推荐引用方式 GB/T 7714 | Wang, Liyan,Li, Mengjie,Lin, Yinzhi,et al. Inhibition of cellular inflammatory mediator production and amelioration of learning deficit in flies by deep sea Aspergillus-derived cyclopenin[J]. JOURNAL OF ANTIBIOTICS,2020,73(9):622, 629. |
| APA | Wang, Liyan.,Li, Mengjie.,Lin, Yinzhi.,Du, Shuwen.,Liu, Zhenyu.,...&Umezawa, Kazuo.(2020).Inhibition of cellular inflammatory mediator production and amelioration of learning deficit in flies by deep sea Aspergillus-derived cyclopenin.JOURNAL OF ANTIBIOTICS,73(9),622. |
| MLA | Wang, Liyan,et al."Inhibition of cellular inflammatory mediator production and amelioration of learning deficit in flies by deep sea Aspergillus-derived cyclopenin".JOURNAL OF ANTIBIOTICS 73.9(2020):622. |
入库方式： OAI收割
来源：南海海洋研究所
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