On-PKS Baeyer-Villiger-Type O-Atom Insertion Catalyzed by Luciferase-Like Monooxygenase OvmO during Olimycin Biosynthesis
文献类型：期刊论文
| 作者 | Zhang, Chunyan2,3; Zhang, Huaran1; Ju, Jianhua1 |
| 刊名 | ORGANIC LETTERS
 |
| 出版日期 | 2020 |
| 卷号 | 22期号:5页码:1780 |
| ISSN号 | 1523-7060 |
| DOI | 10.1021/acs.orglett.0c00076 |
| 英文摘要 | A silent ansamycin biosynthetic gene cluster (ovm) was activated in Streptomyces olivaceus SCSIO T05 following mutagenesis and media optimization. A new shunt product, olimycin C (1a) was produced by the ovmO-inactivated mutant strain, along with a minor product, olimycin D (1b). The production of these linear olimycin counterparts suggest that luciferase-like monooxygenase (LLM) OvmO catalyzes an on-PKS Baeyer-Villiger-type oxidation during assembly of the olimycin A (2) linear polyketide backbone. |
| 资助机构 | National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [U1706206]; Natural Science Foundation of Guangdong ProvinceNational Natural Science Foundation of Guangdong Province [2016A030312014]; Key Special Project for Introduced Talents Team of Southern Marine Science and Engineering Guangdong Laboratory (Guangzhou) [GML2019ZD0406] ; National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [U1706206]; Natural Science Foundation of Guangdong ProvinceNational Natural Science Foundation of Guangdong Province [2016A030312014]; Key Special Project for Introduced Talents Team of Southern Marine Science and Engineering Guangdong Laboratory (Guangzhou) [GML2019ZD0406] |
| 源URL | [http://ir.scsio.ac.cn/handle/344004/18480]  |
| 专题 | 南海海洋研究所_中科院海洋生物资源可持续利用重点实验室 |
| 作者单位 | 1.Chinese Acad Sci, RNAM Ctr Marine Microbiol, South China Sea Inst Oceanol, Guangdong Key Lab Marine Mat Med,CAS Key Lab Trop, Guangzhou 510301, Peoples R China 2.Univ Chinese Acad Sci, Coll Oceanol, Beijing 100049, Peoples R China 3.Chinese Acad Med Sci, Inst Med Biotechnol, Beijing 100050, Peoples R China 4.Peking Union Med Coll, Beijing 100050, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhang, Chunyan,Zhang, Huaran,Ju, Jianhua. On-PKS Baeyer-Villiger-Type O-Atom Insertion Catalyzed by Luciferase-Like Monooxygenase OvmO during Olimycin Biosynthesis[J]. ORGANIC LETTERS,2020,22(5):1780, 1784. |
| APA | Zhang, Chunyan,Zhang, Huaran,&Ju, Jianhua.(2020).On-PKS Baeyer-Villiger-Type O-Atom Insertion Catalyzed by Luciferase-Like Monooxygenase OvmO during Olimycin Biosynthesis.ORGANIC LETTERS,22(5),1780. |
| MLA | Zhang, Chunyan,et al."On-PKS Baeyer-Villiger-Type O-Atom Insertion Catalyzed by Luciferase-Like Monooxygenase OvmO during Olimycin Biosynthesis".ORGANIC LETTERS 22.5(2020):1780. |
入库方式： OAI收割
来源：南海海洋研究所
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