HPLC-DAD-Guided Isolation of Diversified Chaetoglobosins from the Coral-Associated Fungus Chaetomium globosum C2F17
文献类型：期刊论文
| 作者 | Luo, Xiao-Wei; Gao, Cheng-Hai; Lu, Hu-Mu; Wang, Jia-Min; Su, Zi-Qi; Tao, Hua-Ming; Zhou, Xue-Feng; Yang, Bin; Liu, Yong-Hong |
| 刊名 | MOLECULES
 |
| 出版日期 | 2020 |
| 卷号 | 25期号:5页码:1237 |
| 关键词 | coral marine fungi Chaetomium globosum cytochalasans chaetoglobosins cytotoxicity |
| DOI | 10.3390/molecules25051237 |
| 英文摘要 | Cytochalasans have continuously aroused considerable attention among the chemistry and pharmacology communities due to their structural complexities and pharmacological significances. Sixteen structurally diverse chaetoglobosins, 10-(indol-3-yl)-[13]cytochalasans, including a new one, 6-O-methyl-chaetoglobosin Q (1), were isolated from the coral-associated fungus Chaetomium globosum C2F17. Their structures were accomplished by extensive spectroscopic analysis combined with single-crystal X-ray crystallography and ECD calculations. Meanwhile, the structures and absolute configurations of the previously reported compounds 6, 12, and 13 were confirmed by single-crystal X-ray analysis for the first time. Chaetoglobosins E (6) and Fex (11) showed significant cytotoxicity against a panel of cancer cell lines, K562, A549, Huh7, H1975, MCF-7, U937, BGC823, HL60, Hela, and MOLT-4, with the IC50 values ranging from 1.4 mu M to 9.2 mu M. |
| 资助机构 | Guangdong Basic and Applied Basic Research Foundation [2018A0303130219, 2019B151502042]; Special Fund for Bagui Scholars of Guangxi; National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [21772210, 81973235, 21977102]; Development Program of High-level Talent Team under Qihuang Project of Guangxi University of Chinese Medicine (GXUCM) [2018006]; Initial Scientific Research Foundation of Introduced Doctors in 2019 of GXUCM [2019BS021]; Scientific Research Foundation of Institute of Marine Drugs, GXUCM [2018ZD005-A01, 2018ZD005-A17]; Guangdong MEPP Funds [GDOE [2019]A28]; Key Project of Science and Technology Department of Guangxi [AB16380009]; GBABRF [2018A0303130219] ; Guangdong Basic and Applied Basic Research Foundation [2018A0303130219, 2019B151502042]; Special Fund for Bagui Scholars of Guangxi; National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [21772210, 81973235, 21977102]; Development Program of High-level Talent Team under Qihuang Project of Guangxi University of Chinese Medicine (GXUCM) [2018006]; Initial Scientific Research Foundation of Introduced Doctors in 2019 of GXUCM [2019BS021]; Scientific Research Foundation of Institute of Marine Drugs, GXUCM [2018ZD005-A01, 2018ZD005-A17]; Guangdong MEPP Funds [GDOE [2019]A28]; Key Project of Science and Technology Department of Guangxi [AB16380009]; GBABRF [2018A0303130219] |
| 源URL | [http://ir.scsio.ac.cn/handle/344004/18485]  |
| 专题 | 南海海洋研究所_中科院海洋生物资源可持续利用重点实验室 |
| 作者单位 | 1.[Luo, Xiao-Wei 2.Gao, Cheng-Hai 3.Lu, Hu-Mu 4.Guangxi Univ Chinese Med, Inst Marine Drugs, Nanning 530200, Peoples R China 5.[Wang, Jia-Min 6.Zhou, Xue-Feng 7.Yang, Bin 8.Chinese Acad Sci, South China Sea Inst Oceanol, CAS Key Lab Trop Marine Bioresources & Ecol, Guangdong Key Lab Marine Mat Med, Guangzhou 510301, Peoples R China 9.[Su, Zi-Qi 10.Southern Med Univ, Sch Tradit Chinese Med, Guangzhou 510515, Peoples R China |
| 推荐引用方式 GB/T 7714 | Luo, Xiao-Wei,Gao, Cheng-Hai,Lu, Hu-Mu,et al. HPLC-DAD-Guided Isolation of Diversified Chaetoglobosins from the Coral-Associated Fungus Chaetomium globosum C2F17[J]. MOLECULES,2020,25(5):1237. |
| APA | Luo, Xiao-Wei.,Gao, Cheng-Hai.,Lu, Hu-Mu.,Wang, Jia-Min.,Su, Zi-Qi.,...&Liu, Yong-Hong.(2020).HPLC-DAD-Guided Isolation of Diversified Chaetoglobosins from the Coral-Associated Fungus Chaetomium globosum C2F17.MOLECULES,25(5),1237. |
| MLA | Luo, Xiao-Wei,et al."HPLC-DAD-Guided Isolation of Diversified Chaetoglobosins from the Coral-Associated Fungus Chaetomium globosum C2F17".MOLECULES 25.5(2020):1237. |
入库方式： OAI收割
来源：南海海洋研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。