Protein tyrosine phosphatase 1B (PTP1B) inhibitors from the deep-sea fungus Penicillium chrysogenum SCSIO 07007
文献类型：期刊论文
| 作者 | Han, Wenrong2; Cai, Jia1; Zhong, Weimao; Xu, Guangming1; Wang, Fazuo; Tian, Xinpeng; Zhou, Xiaojiang1; Liu, Qingchao2; Liu, Yonghong; Wang, Junfeng |
| 刊名 | BIOORGANIC CHEMISTRY
 |
| 出版日期 | 2020 |
| 卷号 | 96页码:103646 |
| ISSN号 | 0045-2068 |
| 关键词 | Penicillium chrysogenum alpha-pyrone Indolyl diketopiperazine Protein tyrosine phosphatase 1B inhibition |
| DOI | 10.1016/j.bioorg.2020.103646 |
| 英文摘要 | Three new compounds, including two new 3,4,6-trisubstituted alpha-pyrone derivatives, chrysopyrones A and B (1 and 2), and one new indolyl diketopiperazine derivative, penilline C (3), along with twelve known compounds (4-15), were isolated and identified from the fungus Penicillium chrysogenum SCSIO 07007, separated from deep-sea hydrothermal vent environment sample collected from the Western Atlantic. Their structures and absolute configurations were determined by extensive spectroscopic analysis and electronic circular dichroism (ECD) calculations. All of the isolated compounds (1-15) were evaluated for their cytotoxic, antibacterial activities and enzyme inhibitory activities against acetylcholinesterase (AChE), alpha-glycosidase, and protein tyrosine phosphatase 1B (PTP1B). Among them, new compounds chrysopyrones A and B (1 and 2) displayed obvious inhibitory activities against PTP1B with IC50 values of 9.32 and 27.8 mu g/mL, respectively. Furthermore, molecular docking was performed to investigate the inside perspective of the action in PTP1B enzyme. |
| 资助机构 | National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [41776169, 41476136, 21772210]; Institution of South China Sea Ecology and Environmental Engineering, CAS [ISEE2018PY04]; Foundation of Natural Science Basic Research Shaanxi Province of China [2018JM2060]; Guangdong Province Public Welfare Research and Capacity Building Project [2016A020222010]; Pearl River S&T Nova Program of Guangzhou [201710010136] ; National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [41776169, 41476136, 21772210]; Institution of South China Sea Ecology and Environmental Engineering, CAS [ISEE2018PY04]; Foundation of Natural Science Basic Research Shaanxi Province of China [2018JM2060]; Guangdong Province Public Welfare Research and Capacity Building Project [2016A020222010]; Pearl River S&T Nova Program of Guangzhou [201710010136] |
| 源URL | [http://ir.scsio.ac.cn/handle/344004/18487]  |
| 专题 | 南海海洋研究所_中科院海洋生物资源可持续利用重点实验室 |
| 作者单位 | 1.Northwest Univ, Coll Chem Engn, Dept Pharmaceut Engn, Xian 710069, Peoples R China 2.Chinese Acad Sci, South China Sea Inst Oceanol, CAS Key Lab Trop Marine Bioresources & Ecol, Guangdong Key Lab Marine Mat Med, Guangzhou 510301, Peoples R China 3.Hunan Univ Chinese Med, Coll Pharm, Changsha 410208, Peoples R China |
| 推荐引用方式 GB/T 7714 | Han, Wenrong,Cai, Jia,Zhong, Weimao,et al. Protein tyrosine phosphatase 1B (PTP1B) inhibitors from the deep-sea fungus Penicillium chrysogenum SCSIO 07007[J]. BIOORGANIC CHEMISTRY,2020,96:103646. |
| APA | Han, Wenrong.,Cai, Jia.,Zhong, Weimao.,Xu, Guangming.,Wang, Fazuo.,...&Wang, Junfeng.(2020).Protein tyrosine phosphatase 1B (PTP1B) inhibitors from the deep-sea fungus Penicillium chrysogenum SCSIO 07007.BIOORGANIC CHEMISTRY,96,103646. |
| MLA | Han, Wenrong,et al."Protein tyrosine phosphatase 1B (PTP1B) inhibitors from the deep-sea fungus Penicillium chrysogenum SCSIO 07007".BIOORGANIC CHEMISTRY 96(2020):103646. |
入库方式： OAI收割
来源：南海海洋研究所
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