A Luciferase-Like Monooxygenase and Flavin Reductase Pair AbmE2/AbmZ Catalyzes Baeyer-Villiger Oxidation in Neoabyssomicin Biosynthesis
文献类型：期刊论文
| 作者 | Ji, Xiaoqi3; Tu, Jiajia; Song, Yongxiang; Zhang, Chunyan; Wang, Liyan2; Li, Qinglian; Ju, Jianhua3 |
| 刊名 | ACS CATALYSIS
 |
| 出版日期 | 2020 |
| 卷号 | 10期号:4页码:2591 |
| 关键词 | Baeyer-Villiger luciferase-like in monooxygenase flavin reductase neoabyssomicin self-defense |
| ISSN号 | 2155-5435 |
| DOI | 10.1021/acscatal.9b05488 |
| 英文摘要 | Baeyer-Villiger monooxygenases (BVMOs) play important roles in the biosynthesis of natural products. We describe here in vivo gene inactivation/complementation studies as well as in vitro enzyme assays that reveal the bacterial luciferase-like monooxgenase (LLM) AbmE2 and its flavin reductase partner AbmZ as a type II BVMO pair that catalyzes BV oxidation during neoabyssomicin assembly in Streptomyces koyangensis SCSIO 5802. This study provides direct biochemical evidence of an LLM that catalyzes BV oxidation. |
| 资助机构 | China NSFNational Natural Science Foundation of China (NSFC) [31670087, U1706206, 41676151]; Key Special Project for Introduced Talents Team of Southern Marine Science and Engineering Guangdong Laboratory (Guangzhou) [GML2019ZD0406]; Guangdong NSFNational Natural Science Foundation of Guangdong Province [2016A030312014]; Pearl River S&T Nova Program of Guangzhou [201806010109]; Special Support Program for Training High-Level Talents in Guangdong [2016TQ03R288]; CASChinese Academy of Sciences [XDA13020302-2] ; China NSFNational Natural Science Foundation of China (NSFC) [31670087, U1706206, 41676151]; Key Special Project for Introduced Talents Team of Southern Marine Science and Engineering Guangdong Laboratory (Guangzhou) [GML2019ZD0406]; Guangdong NSFNational Natural Science Foundation of Guangdong Province [2016A030312014]; Pearl River S&T Nova Program of Guangzhou [201806010109]; Special Support Program for Training High-Level Talents in Guangdong [2016TQ03R288]; CASChinese Academy of Sciences [XDA13020302-2] |
| 源URL | [http://ir.scsio.ac.cn/handle/344004/18493]  |
| 专题 | 南海海洋研究所_中科院海洋生物资源可持续利用重点实验室 |
| 作者单位 | 1.Shenzhen Univ, Coll Life Sci & Oceanog, Shenzhen 518060, Peoples R China 2.Univ Chinese Acad Sci, Coll Oceanol, Beijing 100049, Peoples R China 3.Chinese Acad Sci, CAS Key Lab Trop Marine Bioresources & Ecol, Guangdong Key Lab Marine Mat Med, RNAM Ctr Marine Microbiol,South China Sea Inst Oc, Guangzhou 510301, Peoples R China |
| 推荐引用方式 GB/T 7714 | Ji, Xiaoqi,Tu, Jiajia,Song, Yongxiang,et al. A Luciferase-Like Monooxygenase and Flavin Reductase Pair AbmE2/AbmZ Catalyzes Baeyer-Villiger Oxidation in Neoabyssomicin Biosynthesis[J]. ACS CATALYSIS,2020,10(4):2591, 2595. |
| APA | Ji, Xiaoqi.,Tu, Jiajia.,Song, Yongxiang.,Zhang, Chunyan.,Wang, Liyan.,...&Ju, Jianhua.(2020).A Luciferase-Like Monooxygenase and Flavin Reductase Pair AbmE2/AbmZ Catalyzes Baeyer-Villiger Oxidation in Neoabyssomicin Biosynthesis.ACS CATALYSIS,10(4),2591. |
| MLA | Ji, Xiaoqi,et al."A Luciferase-Like Monooxygenase and Flavin Reductase Pair AbmE2/AbmZ Catalyzes Baeyer-Villiger Oxidation in Neoabyssomicin Biosynthesis".ACS CATALYSIS 10.4(2020):2591. |
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来源：南海海洋研究所
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