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Heterologous Expression Leads to Discovery of Diversified Lobophorin Analogues and a Flexible Glycosyltransferase

文献类型：期刊论文

作者Tan, Bin; Chen, Siqiang; Zhang, Qingbo; Chen, Yuchan1; Zhu, Yiguang; Khan, Imran; Zhang, Weimin1; Zhang, Changsheng
刊名ORGANIC LETTERS
出版日期2020
卷号22期号:3页码:1062
ISSN号1523-7060
DOI10.1021/acs.orglett.9b04597
英文摘要The heterologous expression of the lobophorin biosynthetic gene cluster from marine-derived Streptomyces pactum SCSIO 02999 has led to the discovery of new analogues that carry D-kijanose (or its variants with a 3-amino or hydroxyl group) at C-9. The identification of intermediates resulting from the inactivation of lobG1 (encoding C-17 kijanosyltransferase) and lobG3 (encoding C-9 digitoxosyltransferase) demonstrates the substrate flexibility of LobG3 to also accept D-kijanose and its variants. Notably, two lobophorins with D-kijanose at C-9 show improved bioactivities.
资助机构Chinese Academy of SciencesChinese Academy of Sciences [XDA13020302, QYZDJ-SSW-DQC004]; NSFCNational Natural Science Foundation of China (NSFC) [31630004, 41911530078]; MOST [2018YFC1406705] ; Chinese Academy of SciencesChinese Academy of Sciences [XDA13020302, QYZDJ-SSW-DQC004]; NSFCNational Natural Science Foundation of China (NSFC) [31630004, 41911530078]; MOST [2018YFC1406705]
源URL[http://ir.scsio.ac.cn/handle/344004/18494]  
专题南海海洋研究所_中科院海洋生物资源可持续利用重点实验室
作者单位1.Chinese Acad Sci, Key Lab Trop Marine Bioresources & Ecol, Guangdong Key Lab Marine Mat Med, South China Sea Inst Oceanol,Inst South China Sea, Guangzhou 510301, Peoples R China
2.Guangdong Inst Microbiol, State Key Lab Appl Microbiol Southern China, Guangdong Prov Key Lab Microbial Culture Collect, Guangzhou 510070, Peoples R China
推荐引用方式
GB/T 7714		 Tan, Bin,Chen, Siqiang,Zhang, Qingbo,et al. Heterologous Expression Leads to Discovery of Diversified Lobophorin Analogues and a Flexible Glycosyltransferase[J]. ORGANIC LETTERS,2020,22(3):1062, 1066.
APA Tan, Bin.,Chen, Siqiang.,Zhang, Qingbo.,Chen, Yuchan.,Zhu, Yiguang.,...&Zhang, Changsheng.(2020).Heterologous Expression Leads to Discovery of Diversified Lobophorin Analogues and a Flexible Glycosyltransferase.ORGANIC LETTERS,22(3),1062.
MLA Tan, Bin,et al."Heterologous Expression Leads to Discovery of Diversified Lobophorin Analogues and a Flexible Glycosyltransferase".ORGANIC LETTERS 22.3(2020):1062.

入库方式： OAI收割

来源：南海海洋研究所

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