Asperpentenone A, A novel polyketide isolated from the deep-sea derived fungus Aspergillus sp. SCSIO 41024
文献类型：期刊论文
| 作者 | Chen, Weihao4; Liu, Haiyi1; Long, Jieyi4; Tao, Huaming1; Lin, Xiuping; Liao, Shengrong; Yang, Bin; Zhou, Xuefeng; Liu, Yonghong3,4; Wang, Junfeng |
| 刊名 | PHYTOCHEMISTRY LETTERS
 |
| 出版日期 | 2020 |
| 卷号 | 35页码:99 |
| 关键词 | Polyketide Antibacterial activity Deep-sea Aspergillus |
| ISSN号 | 1874-3900 |
| DOI | 10.1016/j.phytol.2019.11.009 |
| 英文摘要 | Asperpentenone A (1), a novel polyketide with a rare cyclopentenone-tetrahydrofuran moiety, was isolated along with eight known compounds (2-9) from the deep-sea derived fungus Aspergillus sp. SCSIO 41024. Their structures including absolute configurations were determined by extensive analysis of their spectroscopic analysis and X-ray crystallography. Biological evaluation results revealed that kojic acid (3) showed weak antibacterial activities against Bacillus thuringiensis and Acinetobacter baumannii with MIC values of 32 and 128 mu g/mL, respectively. Furthermore, griseofamine A (9) exhibited weak antibacterial activity with an MIC value of 64 mu g/mL against Escherichia coli. The results of antibacterial experiments and especially the large yield of kojic acid (3) indicated that kojic acid might represent a candidate precursor for the development of antimicrobial agents. |
| 资助机构 | National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [21772210, 41776169]; Institution of South China Sea Ecology and Environmental Engineering, CAS [ISEE2018PY04]; Guangdong MEPP Fund [GDOE [2019]A28]; Pearl River S&T Nova Program of Guangzhou [201710010136]; Guangzhou Science and Technology Project [201804010462] ; National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [21772210, 41776169]; Institution of South China Sea Ecology and Environmental Engineering, CAS [ISEE2018PY04]; Guangdong MEPP Fund [GDOE [2019]A28]; Pearl River S&T Nova Program of Guangzhou [201710010136]; Guangzhou Science and Technology Project [201804010462] |
| 源URL | [http://ir.scsio.ac.cn/handle/344004/18504]  |
| 专题 | 南海海洋研究所_中科院海洋生物资源可持续利用重点实验室 |
| 作者单位 | 1.Univ Chinese Acad Sci, 19 Yuquan Rd, Beijing 100049, Peoples R China 2.Chinese Acad Sci, Inst South China Sea Ecol & Environm Engn, Guangzhou 510301, Peoples R China 3.Southern Med Univ, Sch Tradit Chinese Med, Guangzhou 510515, Peoples R China 4.Chinese Acad Sci, South China Sea Inst Oceanol, CAS Key Lab Trop Marine Bioresources & Ecol, Guangdong Key Lab Marine Mat Med, Guangzhou 510301, Peoples R China |
| 推荐引用方式 GB/T 7714 | Chen, Weihao,Liu, Haiyi,Long, Jieyi,et al. Asperpentenone A, A novel polyketide isolated from the deep-sea derived fungus Aspergillus sp. SCSIO 41024[J]. PHYTOCHEMISTRY LETTERS,2020,35:99, 102. |
| APA | Chen, Weihao.,Liu, Haiyi.,Long, Jieyi.,Tao, Huaming.,Lin, Xiuping.,...&Wang, Junfeng.(2020).Asperpentenone A, A novel polyketide isolated from the deep-sea derived fungus Aspergillus sp. SCSIO 41024.PHYTOCHEMISTRY LETTERS,35,99. |
| MLA | Chen, Weihao,et al."Asperpentenone A, A novel polyketide isolated from the deep-sea derived fungus Aspergillus sp. SCSIO 41024".PHYTOCHEMISTRY LETTERS 35(2020):99. |
入库方式： OAI收割
来源：南海海洋研究所
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